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September 1982

Kinetics and Fate of Indium 111 Oxine-Labeled Platelets in Patients With Aortic Aneurysms

Author Affiliations

From the Blood Platelet Research Unit, South African Medical Research Council (Drs Heyns, Lötter, Badenhorst, Pieters, and Minnaar), and the Department of Surgery, University of the Orange Free State (Dr Nel), Bloemfontein, Republic of South Africa.

Arch Surg. 1982;117(9):1170-1174. doi:10.1001/archsurg.1982.01380330032009

• The survival and sites of sequestration of indium 111 oxine—labeled autologous platelets were studied quantitatively in six patients with aortic aneurysms. The in vivo distribution was quantitated daily with a scintillation camera and a computer-assisted imaging system. Data of platelet survival curves were fitted to a gamma function model. Mean platelet survival was shortened and the disappearance curves were exponential in all but two patients who had normal platelet survival. Platelet radioactivity in the aneurysm was 5.1 ± 3% of whole-body radioactivity at the end of platelet survival. Platelets were sequestered in the spleen, liver, and bone marrow. Accumulation of platelets, presumably due to microembolization, was prominent in the lower limbs. This indicates that although platelets were deposited in the aneurysm, many are damaged and are eventually sequestered in the reticuloendothelial system.

(Arch Surg 1982;117:1170-1174)

Baumgartner HR:  The subendothelial surface and thrombosis , in Deutsch E, Brinkhous KM, Lechner K, et al (eds): Thrombosis: Pathogenesis and Clinical Trials . New York, Schattauer Verlag, 1974, p 91.
Mustard JF, Packham MA:  The role of blood and platelets in atherosclerosis and complications of atherosclerosis . Thromb Diath Haemorrh 1975;33:444-456.
Jorgenson L:  The role of platelet embolism from crumbling thrombi and of platelet aggregates arising in flowing blood , in Sherry S, Brinkhous KM, Genton E (eds): Thrombosis . Washington, DC, National Academy of Sciences, 1969, p 506.
Ross R, Harker LA:  Hyperlipidemia and atherosclerosis . Science 1976;193:1094-1100.Article
Ross R, Glomset JA:  Pathogenesis of atherosclerosis . N Engl J Med 1976;195:369-377, 420-425.Article
Abrahamsen AF:  Platelet survival studies in man—with special reference to thrombosis and atherosclerosis . Scand J Haematol , 1968, (suppl 3) , pp 1-53.
Harker LA, Slichter SJ:  Platelet and fibrinogen consumption in man . N Engl J Med 1972;287:999-1005.Article
Steel P, Battock D, Genton E:  Effects of clofibrate and sulfinpyrazone on platelet survival time in coronary artery disease . Circulation 1975;52:473-476.Article
Ritchie JL, Harker LA:  Platelet and fibrinogen survival in coronary atherosclerosis: Response to medical and surgical therapy . Am J Cardiol 1977;39:595-598.Article
Thakur ML, Welch MJ, Joist JH, et al:  Indium-111-labeled platelets: Studies on preparation and evaluation of in vitro and in vivo functions . Thromb Res 1976;9:345-357.Article
Heyns AduP, Lötter MG, Badenhorst PN, et al:  Kinetics, distribution and sites of destruction of 111indium-labelled human platelets . Br J Haematol 1980;44:269-280.Article
Lötter MG, Badenhorst PN, Heyns AduP, et al:  Kinetics, distribution and sites of destruction of canine blood platelets with In-111-oxine . J Nucl Med 1980;21:36-40.
Heyns AduP, Badenhorst PN, Pieters H, et al:  Preparation of a viable population of indium-111-labelled human blood platelets . Thromb Haemost 1980;42:1473-1482.
 Panel on diagnostic application of radio-isotopes in haematology: Recommended methods for radio-isotope platelet survival studies . Blood 1977;50:1137-1144.
Nadler SB, Hidalgo JU, Bloch T:  Prediction of blood volume in normal human adults . Surgery 1962;51:224-232.
Bull BS, Schneiderman MA, Brecher G:  Platelet counts with the Coulter counter . Am J Clin Pathol 1965;44:678-688.
Murphy EA, Francis ME:  The estimation of blood platelet survival: II. The multiple hit model . Thromb Diath Haemorrh 1971;25:53-80.
Heyns AduP, Lötter MG, Badenhorst PN, et al:  Kinetics and in vivo redistribution of 111indium-labelled human platelets after intravenous protamine sulphate . Thromb Haemost 1980;44:65-68.
Heyns AduP, Lötter MG, Badenhorst PN, et al:  Kinetics and fate of 111indium-oxine labelled blood platelets in asplenic subjects . Thromb Haemost 1980;44:100-104.
Cooper RA:  Destruction of erythrocytes , in Williams WJ, Beutler E, Erslev AJ, et al (eds): Hematology , ed 2. New York, McGraw-Hill Book Co Inc, 1977, p 216.