[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
April 1984

Abdominal Aortic Aneurysm, Leriche's Syndrome, Inguinal Herniation, and Smoking

Author Affiliations

From the Departments of Biochemistry (Dr Cannon) and Surgery (Dr Read and Ms Casteel), University of Arkansas for Medical Sciences, Little Rock, and the Surgical Service, Little Rock (Ark) Veterans Administration Medical Center (Dr Read).

Arch Surg. 1984;119(4):387-389. doi:10.1001/archsurg.1984.01390160023005

• We previously found an increase in serum proteolytic activity in smokers with direct inguinal herniation and a similar imbalance in smokers with abdominal aortic aneurysm (AAA), but not in smokers with Leriche's syndrome (LS). If the protease imbalance in the blood of smokers with AAA or herniation is a causal factor, these conditions should be associated. Therefore, we determined whether this is true using patients with LS as control subjects. The frequency of inguinal herniation was significantly higher in the AAA population (N=341; 25.8%) than in patients with LS (N =417; 14.6%). In addition, patients with AAA had more severe herniation (direct, bilateral, recurrent, or earlier onset) and had more pronounced leukocytosis (9,000/cu mm v 8,190/cu mm). These data suggest that increased blood proteolytic activity may play a role in the development of both AAA and adult inguinal herniation but not LS. Men who smoke manifest different systemic effects.

(Arch Surg 1984;119:387-389)

Cannon DJ, Read RC:  Metastatic emphysema: A mechanism for acquiring inguinal herniation . Ann Surg 1981;194:270-278.Article
Cannon DJ, Read RC:  Blood elastolytic activity in patients with aortic aneurysm . Ann Thorac Surg 1982;34:10-15.Article
Dent TL, Lindenauer SM, Ernst CB, et al:  Multiple arteriosclerotic arterial aneurysms . Arch Surg 1972;105:338-344.Article
Hollier LH, Stanson AW, Gloviczki P, et al:  Arteriomegaly: Classification and morbid implications of diffuse aneurysmal disease . Surgery 1983;93:700-708.
Rowe DW, McGoodwin EB, Martin GR, et al:  A sex linked defect in the crosslinking of collagen and elastin associated with the mottled locus in mice . J Exp Med 1974;139:180-192.Article
Hunt DM:  Primary defect in copper transport underlies mottled mutant in the mouse . Nature 1974;249:852-854.Article
Tilson MD:  Decreased hepatic copper levels: A possible chemical marker for the pathogenesis of aortic aneurysms in man . Arch Surg 1982;117:1212-1213.Article
Tilson MD, Davis G:  Deficiencies of copper and a compound with ironexchange characteristics of pyridinoline in skin from patients with abdominal aortic aneurysms . Surgery 1983;94:134-141.
Alston JD, Fody EP, Couch L, et al:  Hepatic and skin copper levels in patients with abdominal aortic aneurysms . Surg Forum 1983;34:466-467.
Read RC:  Attenuation of the rectus sheath in inguinal herniation . Am J Surg 1970;120:610-615.Article