[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
August 1985

Postoperative Albumin Infusion Therapy Based on Colloid Osmotic PressureA Prospectively Randomized Trial

Author Affiliations

From the Chirurgische Universitätsklinik Köln-Lindenthal, Köln, West Germany.

Arch Surg. 1985;120(8):911-915. doi:10.1001/archsurg.1985.01390320035006

• In a prospectively randomized trial of 220 patients, 106 were given albumin when their colloid osmotic pressure (COP) fell below 24 cm H2O and 114 were given albumin when their COP fell below 29 cm H2O. There was no difference in the postoperative course between the two groups; however, by using the lower COP limit the postoperative albumin consumption in the intensive care unit was reduced significantly and thus the costs of treatment were lowered. In the case of extremely low COP, the prognosis of the disease worsened, indicating that the COP is of prognostic value. The albumin supply, however, did not influence the final outcome of the patients under these circumstances because it treated only a characteristic symptom and not the cause of the disease.

(Arch Surg 1985;120:911-915)

Hauser CJ, Shoemaker WC, Turpin I, et al:  Oxygen transport responses to colloids and crystalloids in critically ill surgical patients . Surg Gynecol Obstet 1980;150:811-816.
Shoemaker WC, Schluchter M, Hopkins JA, et al:  Comparison of the relative effectiveness of colloids and crystalloids in emergency resuscitation . Am J Surg 1981;142:73-84.Article
Dahn MS, Lucas CE, Ledgerwood AM:  Negative inotropic effect of albumin resuscitation for shock . Surgery 1979;86:235-241.
Lucas CE, Ledgerwood AM, Higgins RF:  Impaired salt and water excretion after albumin resuscitation for hypovolemic shock . Surgery 1979;86:544-549.
Lowe RJ, Moss GS, Jilek J, et al:  Crystalloid vs colloid in the etiology of pulmonary failure after trauma: A randomized trial in man . Surgery 1977;81:676-683.
Moss GS, Lowe RJ, Jilek J, et al:  Colloid or crystalloid in the resuscitation of hemorrhagic shock: A controlled clinical trial . Surgery 1981;89:434-438.
Shires GT, Peitzman AB, Albert SA, et al:  Response of extravascular lung water to intraoperative fluids . Ann Surg 1983;197:515-519.Article
Virgilio RW, Rice CL, Smith DE, et al:  Crystalloid vs colloid resuscitation: Is one better? Surgery 1979;85:129-139.
Lucas CE, Ledgerwood AM:  The fluid problem in the critically ill . Surg Clin North Am 1983;63:439-454.
Boutros AR, Ruess R, Olson L, et al:  Comparison of hemodynamic, pulmonary, and renal effects of use of three types of fluids after major surgical procedures on the abdominal aorta . Crit Care Med 1979;7:9-13.Article
Morissette M, Weil MH, Shubin H:  Reduction in colloid osmotic pressure associated with fatal progression of cardiopulmonary failure . Crit Care Med 1975;3:115-117.Article
Morissette M:  Colloid osmotic pressure: Its measurement and clinical value . Can Med Assoc J 1977;116:897-900.
Puri VK, Weil MH, Michaels S, et al:  Pulmonary edema associated with reduction in plasma oncotic pressure . Surg Gynecol Obstet 1980;151: 344-348.
Tonnesen AS, Gabel JC, McLeavey CA:  Relation between lowered colloid osmotic pressure, respiratory failure, and death . Crit Care Med 1977;5:239-240.Article
Peters RM, Hargens AR:  Protein vs electrolytes and all of the Starling forces . Arch Surg 1981;116:1293-1298.Article
Jing DL, Kohler JP, Rice CL, et al:  Albumin therapy in permeability pulmonary edema . J Surg Res 1982;33:482-488.Article
Sturm JA, Carpenter MA, Lewis FR, et al:  Water and protein movement in the sheep lung after septic shock: Effect of colloid versus crystalloid resuscitation . J Surg Res 1979;26:233-248.Article
Grundmann R, Höher M, Pichlmaier H:  Kolloidosmotischer Druck: Ein Parameter zur postoperativen Eiweisstherapie: Eine Pilotstudie . Chirurgie 1983;54:323-328.
Hernández-Richter HJ, Struck H:  Wundheilung und ihre Störungen, chirurgische Infektionen , in Lindenschmidt ThO (ed): Pathophysiologische Grundlagen der Chirurgie . Stuttgart, West Germany, Georg Thieme Verlag, 1975, pp 124-135.
Grundmann R, Meyer H:  Der Einfluss von Operation und Hämodilution auf den kolloidosmotischen Druck . Chirurg 1980;51:594-600.
Coward WA:  Serum colloidal osmotic pressure in the development of kwashiorkor and in recovery: Its relationship to albumin and globulin concentrations and edema . Br J Nutr 1975;34:459-467.
Tranbaugh RF, Lewis FR, Christensen JM, et al:  Lung water changes after thermal injury: The effects of crystalloid resuscitation and sepsis . Ann Surg 1980;192:479-490.Article