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Article
September 1985

Elemental Diet as Prophylaxis Against Radiation InjuryHistological and Ultrastructural Studies

Author Affiliations

From the Departments of Surgery (Drs McArdle and Wittnich), Radiation Oncology (Dr Freeman), and Pathology (Dr Duguid), The Montreal General Hospital.

Arch Surg. 1985;120(9):1026-1032. doi:10.1001/archsurg.1985.01390330038007
Abstract

• We investigated whether elemental diet feeding would protect the intestine from radiation injury. Five dogs were fed an elemental diet for three days before receiving pelvic irradiation (500 rad/day for four days) and were maintained on the diet during the days of irradiation. These dogs were compared with five dogs that were fed normal kennel ration, but were treated similarly otherwise. One day and five days following completion of the radiation treatment, the dogs were anesthetized and a biopsy specimen of terminal ileum was taken for histologic and electron microscopic studies. In the dogs fed the elemental diet, there was no significant damage to the intestine seen on histological examination, and electron microscopy disclosed elongated microvilli and no organelle damage. However, both histological and electron microscopic examination of the intestine from dogs maintained on normal kennel ration showed that severe damage had occurred from the irradiation procedure. It seems, therefore, that the feeding of an elemental diet to dogs as a prophylaxis can afford protection to the intestine from the acute phase of radiation injury.

(Arch Surg 1985;120:1026-1032)

References
1.
Rubin P, Casarett GW:  Clinical radiation pathology as applied to curative radiotherapy . Cancer 1968;22:767-778.Article
2.
Berthrong M, Fajardo LF:  Radiation injury in surgical pathology: II. Alimentary tract . Am J Surg Pathol 1981;5:153-178.Article
3.
Donaldson SS, Jundt S, Ricour C, et al:  Radiation enteritis in children: A retrospective review, clinicopathologic correlation and dietary management . Cancer 1975;35:1167-1178.Article
4.
Bounous G, Sutherland NG, McArdle AH, et al:  The prophylactic use of an 'elemental diet' in experimental hemorrhagic shock and intestinal ischemia . Ann Surg 1967;166:312-343.Article
5.
Langlois P, Williams HB, Gurd FN:  Effect of an elemental diet on mortality rates and gastrointestinal lesions in experimental burns . J Trauma 1972;12:771-777.Article
6.
McArdle AH:  Studies on the prophylactic use of Vital for protection of the intestine from ischemic injury . Fed Proc 1981;40:852.
7.
Shaffer EA, Brown RA, Dutton JW:  The effects of massive small bowel resection , in Bouchier IA (ed): Recent Advances in Gastroenterology . Edinburgh, Churchill Livingstone, 1976, pp 73-95.
8.
Lehnert S:  Changes in growth kinetics of jejunal epithelium in mice maintained on elemental diet . Cell Tissue Kin 1979;12:239-248.
9.
Ferguson GA: Statistical Analysis in Psychology and Education . New York, McGraw-Hill Book Co, 1971, pp 223-245.
10.
Bond VP:  Effects of radiation on intestinal absorption . Am J Clin Nutr 1963;12:194-204.
11.
Donaldson SS, Lenon RA:  Alterations of nutritional status: Impact of chemotherapy and radiation therapy . Cancer 1979;43:2036-2052.Article
12.
Greenberger NJ, Isselbacker KJ:  Malabsorption following radiation injury to the gastrointestinal tract . Am J Med 1964;36:450-456.Article
13.
Bounous G, Hugon J, Gentile J:  Elemental diet in the management of the intestinal lesion produced by 5-fluorouracil in the rat . Can J Surg 1971;14:298-311.
14.
Bounous G, Gentile J, Hugon J:  Elemental diet in the management of the intestinal lesion produced by 5-fluorouracil in man . Can J Surg 1971;14:312-324.
15.
Bounous G, Lebel E, Shuster J, et al:  Dietary production during radiation therapy . Stralentherapie 1975;149:476-483.
16.
Rivilis J, McArdle AH, Wlodek G:  Effect of elemental diet on gastric secretion . Am J Surg 1974;128:690-692.Article
17.
McArdle AH, Echave V, Brown RA, et al:  Effect of elemental diet on pancreatic secretion . Am J Surg 1974;128:690-692.Article
18.
Hill GL, Mair WSJ, Edwards JP, et al:  Decreased trypsin and bile acids in ileal fistula drainage during the administration of a chemically defined liquid elemental diet . Br J Surg 1976;63:133-136.Article
19.
Alpers DH, Tedesco FJ:  Possible role of pancreatic proteases in the turnover of intestinal brush border enzymes . Biochim Biophys Acta 1975;401:28-40.Article
20.
Vasseur M, Ferard G, Pousse A:  Rat intestinal brush border enzymes release by deoxycholate in vivo . Pflugers Arch 1978;373:133-138.Article
21.
Maestracci D:  Enzymic solubilization of the human intestinal brush border membrane enzymes . Biochim Biophys Acta 1976;433:469-481.Article
22.
Bounous G:  Role of the intestinal contents in the pathophysiology of acute intestinal ischemia . Am J Surg 1967;114:368-375.Article
23.
Brown RA, Chiu CJ, Scott HJ, et al:  Ultrastructural changes in the canine ileal mucosal cell after mesenteric arterial occlusion . Arch Surg 1970;101:290-297.Article
24.
Rottger P, Schneider M, Huebner K, et al:  Investigations on the enzyme content, the ultrastructure, and the regeneration of the upper jejunum of the rat following temporary total ischemia , in Varro V, Balint GA (eds): Current Views in Gastroenterology . Budapest, Hungarian Society of Gastroenterology Press, 1977, pp 127-141.
25.
Morgenstern L, Hiatt N:  Injurious effects of pancreatic secretions on post-radiation enteropathy . Gastroenterology 1967;53:923-929.
26.
Morgenstern L, Patin CS, Krohn HL, et al:  Prolongation of survival in lethally irradiated dogs by pancreatic duct ligation . Arch Surg 1970;101:586-589.Article
27.
Robinson JWL, Mirkovitch V, Winstorfer B, et al:  Response of the intestinal mucosa to ischemia . Gut 1981;22:512-527.Article
28.
Vracko R:  Significance of basal lamina for regeneration of injured lung . Virchows Arch Pathol Anat 1972;355:264-274.Article
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