[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
March 1989

DNA Ploidy and Tumor Invasion in Human Gastric CancerHistopathologic Differentiation

Author Affiliations

From the Department of Surgery II, Kyushu University Faculty of Medicine, Fukuoka, Japan.

Arch Surg. 1989;124(3):314-318. doi:10.1001/archsurg.1989.01410030064011

• The relationship between DNA ploidy and tumor invasion in 254 patients with gastric carcinoma was studied, with particular emphasis on histopathologic features. In the differentiated type of adenocarcinoma, there were aneuploid lesions characterized by a relatively high incidence of lymph node metastasis and hematogenous recurrence, even when the invasion was limited to the submucosa. In the undifferentiated type, aneuploid lesions were rarely seen at the early stage, but the frequency remarkably increased with invasion into the deeper layers. Nodal involvement and disseminating metastasis were evident with serosal invasion. Analyzed by a multivariate Cox model, DNA ploidy significantly correlated with prognosis. Thus, DNA ploidy is a major determinant of survival, and the behavior of an aneuploid carcinoma is apparently controlled by individual histologic type.

(Arch Surg 1989;124:314-318)

Banner BF, Vega JETL, Roseman DL, et al:  Should flow cytometric DNA analysis precede definitive surgery for colon carcinoma? Ann Surg 1985;202:740-744.Article
Matsuura H, Sugimachi K, Ueo H, et al:  Malignant potentiality of squamous cell carcinoma of the esophagus predictable by DNA analysis . Cancer 1986;57:1810-1814.Article
Frankfult OS, Chin JL, Englander LS, et al:  Relationship between DNA ploidy, glandular differentiation and tumor spread in human prostate cancer . Cancer Res 1985;45:1418-1423.
Frankfult OS, Slocum HK, Rustum YM, et al:  Flow cytometric analysis of DNA aneuploidy in primary and metastatic human solid tumors . Cytometry 1984;5:71-80.Article
Dowle CS, Owainati A, Robins A, et al:  Prognostic significance of the DNA content of human breast cancer . Br J Surg 1987;74:133-136.Article
Matsusaka T, Kodama Y, Soejima K, et al:  Recurrence in early gastric cancer: A pathologic evaluation . Cancer 1980;46:168-172.Article
Kodama Y, Inokuchi K, Soejima K, et al:  Growth patterns and prognosis in early gastric carcinoma: Superficially spreading and penetrating growth types . Cancer 1983;51:320-326.Article
Inokuchi K, Kodama Y, Sasaki O, et al:  Differentiation of growth patterns of early gastric carcinoma determined by cytophotometric DNA analysis . Cancer 1983;51:1138-1141.Article
Czerniak B, Herz F, Koss LG:  DNA distribution patterns in early gastric carcinomas: A Feulgen cytometric study of gastric brush smears . Cancer 1987;59:113-117.Article
Petrova AS, Subrichina GN, Tschistjakova OV, et al:  Flow cytofluorometry, cytomorphology and histology in gastric carcinoma . Oncology 1980;37:318-324.Article
Ribeiro MM, Simoes MAS, Bastos J:  Analysis of 242 cases of gastric carcinoma . World J Surg 1981;5:97-102.Article
Sugano H, Nakamura K, Kato Y:  Pathological studies of human gastric cancer . Acta Pathol Jpn 1982;32( (suppl) ):329-347.
Naora H:  Microspectrophotometry of cell nucleus stained by Feulgen reaction: I. Microspectrophotometric apparatus without Schwarzchild-Villiger effect . Exp Cell Res 1955;8:259-278.Article
Mendersohn ML:  The two-wavelength method of microspectrophotometry: II. A set of tables to facilitate the calculations . J Cell Biol 1958;4:415-424.Article
Korenaga D, Okamura T, Saito A, et al:  DNA ploidy is closely linked to lymph node metastasis, tumor invasion and prognosis in clinical gastric cancer . Cancer 1988;62:309-313.Article
Korenaga D, Mori M, Okamura T, et al:  DNA ploidy in clinical malignant gastric lesions less than 5 mm in diameter . Cancer 1986;58:2542-2545.Article
Haraguchi M, Okamura T, Korenaga D, et al:  Heterogeneity of DNA ploidy in patients with undifferentiated carcinomas of the stomach . Cancer 1987;59:922-924.Article
Japanese Research Society for Gastric Cancer:  The general rules for the gastric cancer study in surgery and pathology . Jpn J Surg 1981;11:127-139.Article
Kaplan EL, Meier P:  Nonparametric estimation from incomplete observation . J Am Stat Assoc 1958;53:457-481.Article
Cox DR:  Regression models and life tables . J R Stat Soc 1972;343:187-220.
Korenaga D, Haraguchi M, Okamura T, et al:  Consistency of DNA ploidy between primary and recurrent gastric carcinomas . Cancer Res 1986;46:1544-1546.
Hattori T, Hosokawa Y, Fukuda M, et al:  Analysis of DNA ploidy patterns of gastric carcinomas of Japanese . Cancer 1984;54:1591-1597.Article