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Article
August 1991

Not All Nonpalpable Breast Cancers Are Alike

Author Affiliations

From the University Hospitals of Cleveland (Ohio), Case Western Reserve University.

Arch Surg. 1991;126(8):967-971. doi:10.1001/archsurg.1991.01410320049005
Abstract

• Clinical and mammographic data of 1009 consecutive patients were correlated with histopathologic data of 1144 biopsy specimens of nonpalpable breast lesions to better define the presentation and biologic behavior of early breast cancer. Patients with malignant neoplasms (269 [24%] of 1144 specimens) were older (mean age, 62.1 years) than patients with benign lesions (mean age, 54.9 years). Furthermore, patients with invasive disease were older (mean age, 63.3 years) than patients with noninvasive disease (mean age, 58.5 years) with an overall increased risk of invasive cancer per year of 1.035. A 58% incidence of invasive cancer was detected for lesions characterized by calcifications, while the incidence of invasive cancer was 84% for isolated mass lesions (relative risk, 4.31 for masses). Isolated mammographic calcifications associated with cancer appeared in a younger population and were significantly associated with noninvasive ductal cancer. Breast cancer presenting as a mammographic mass appeared in an older group and was highly associated with the presence of invasive disease.

(Arch Surg. 1991;126:967-971)

References
1.
Fox MS.  On the diagnosis and treatment of breast cancer . JAMA . 1979;241:489-494.Article
2.
Gibb NM.  Comparative study of the histopathology of breast cancer in a screened and unscreened population investigated by mammography . Histopathology . 1985;9:1307-1318.Article
3.
Rodes ND, Lopez MJ, Pearson DK, Blackwell CW, Lankford HD.  The impact of breast cancer screening on survival: a 5- to 10-year follow-up study . Cancer . 1986;57:581-585.Article
4.
Symmonds RE, Roberts JW.  Management of nonpalpable breast abnormalities . Ann Surg . 1987;205:520-528.Article
5.
Margolin FR, Lagios MD.  Mammographic detection of early breast cancer: ten years' experience in a community hospital . West J Med . 1986;144:46-48.
6.
Kopans DB, Lindfors K, McCarthy KA, Meyer JE.  Spring hookwire breast lesion localizer: use with rigid-compression mammographic systems . Radiology . 1985;157:537-538.Article
7.
Franceschi D, Crowe J, Zollinger R, et al.  Breast biopsy for mammographically detected lesions . Surg Gynecol Obstet . 1990;171:449-455.
8.
Rosen PP, Groshen S, Saigo PE, Kinne DW, Hellman S.  A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma . Clin Oncol . 1989;7:355-366.
9.
Mueller CB.  Stage II breast cancer is not simply a late stage I . Surgery . 1988;104:631-638.
10.
Gump FE, Jicha DL, Ozello L.  Ductal carcinoma in situ (DCIS): a revised concept . Surgery . 1987;102:790-795.
11.
Meyer JE, Eberlein TJ, Stomper PC, Sonnenfield MR.  Biopsy of occult breast lesions: analysis of 1261 abnormalities . JAMA . 1990;263:2341-2343.Article
12.
Marrujo G, Jolly PC, Hall MH.  Nonpalpable breast cancer: needle-localized biopsy for diagnosis and considerations for treatment . Am J Surg . 1986;151:599-602.Article
13.
Rosner D, Bedwani RN, Baker VJ, Murphy GP.  Noninvasive breast carcinoma: results of a national survey by the American College of Surgeons . Ann Surg . 1980;192:139-147.Article
14.
Lagios MD, Margolin FR, Westdahl PR, Rose MR.  Mammographically detected duct carcinoma in situ: frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence . Cancer . 1989;63:618-624.Article
15.
Lagios MD, Westdahl PR, Margolin FR, Rose MR.  Duct carcinoma in situ: relationship of extent of noninvasive disease to the frequency of occult invasion, multicentricity, lymph node metastases and short-term treatment failures . Cancer . 1982;50:1309-1314.Article
16.
Silverstein MJ, Rosser RJ, Gierson ED, et al.  Axillary lymph node dissection for intraductal breast carcinoma: is it indicated? Cancer . 1987;59:1819-1824.Article
17.
Frykberg ER, Santiago F, Betsill WL, O'Brien PH.  Lobular carcinoma in situ of the breast . Surg Gynecol Obstet . 1987;164:285-301.
18.
Rosen PP, Lieberman PH, Braun DW, Adair F.  Lobular carcinoma in situ of the breast: detailed analysis of 99 patients with average follow-up of 24 years . Am J Pathol . 1978;3:225-251.Article
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