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December 1992

Paragangliomas of the Neck

Author Affiliations

From the Section of Surgical Oncology (Drs Bishop, Urist, and Maddox) and Division of Otorhinolaryngology (Dr Peters), Department of Surgery; and Division of Neuroradiology, Department of Radiology (Dr EI Gammal), University of Alabama at Birmingham.

Arch Surg. 1992;127(12):1441-1445. doi:10.1001/archsurg.1992.01420120075014

• Between 1967 and 1990 inclusive, 28 patients with paragangliomas of the neck were diagnosed at the University of Alabama at Birmingham Affiliated Hospitals. There were 11 men and 17 women, whose ages ranged from 12 to 76 years (mean, 47 years). Tumor locations included the carotid bodies (19 cases), the vagus nerves (three), supraglottic larynx (two), the left lateral pharyngeal wall (one), posterior to the right jugular vein (not otherwise defined) (one), subcutaneous neck tissue (one), and a cervical lymph node with unknown primary (one). Diagnostic workup included angiography (23 cases) with preoperative embolization (three), computed tomography (one), magnetic resonance imaging (two), and urinary catecholamine assay (four). All 28 patients underwent resection of the lesions. Cranial nerve damage occurred in 11 patients (39%). There were no perioperative deaths or cerebrovascular accidents, although one of two saphenous vein grafts became thrombotic after carotid body tumor resection.

(Arch Surg. 1992;127:1441-1445)

Dorland's Illustrated Medical Dictionary . 26th ed. Philadelphia, Pa: WB Saunders Co; 1981:557.
Zak FG, Lawson W. The Paraganglionic Chemoreceptor System . New York, NY: Springer Verlag NY Inc; 1982:50-51, 235-266.
Kohn A. Quoted by: Sykes JM.  Die paraganglion . Arch Mihr Anat . 1903;62:263.Article
Meyer FB, Sundt TM, Pearson BW.  Carotid body tumors: a subject review and suggested surgical approach . J Neurosurg . 1986;64:377-385.Article
Vogl T, Brüning R, Grevers C, Schedel H, Kang K, Hahn D, Lissner T.  Paragangliomas of the juglar bulb and carotid body: MR imaging with short sequences and Gd-DTPA enhancement . AJNR Am J Neuroradiol . (July) -Aug 1989, 10:823-827.
Gratiot JH. Quoted by: Meyer FB.  Carotid body tumors: collective review . Int Abst Surg . 1943;77:177-186.
Byrne JT.  Carotid body and allied tumors . Am J Surg . 1958;95:371-384.Article
Pacheuo-Ojeda L, Durango E, Rodriguez C, Vivar N.  Carotid body tumors at high altitudes: Quite, Ecuador, 1987 . World J Surg . 1988;12:856-860.Article
Rodriquez-Cueras H, Lau I, Rodriguez HP.  High altitude paragangliomas: diagnostic and therapeutic considerations . Cancer . 1986;57:672-676.Article
Saldana MJ, Salem LE, Travezan R.  High altitude hypoxia and chemodectomas . Hum Pathol . 1973;4:251-263.Article
Chedid A, Jao W.  Hereditary tumors of the carotid bodies and COPD . Cancer . 1974;33:1635-1641.Article
Farr HW.  Carotid body tumors: a 30-year experience at Memorial Hospital . Am J Surg . 1967;114:614-619.Article
Hodge KM, Byers RM, Peters LJ.  Paragangliomas of the head and neck . Arch Otolaryngol Head Neck Surg . 1988;114:872-877.Article
Shamblin WR, Remine WH, Sheps SG, Harrison EG Jr.  Carotid body tumor (chemodectoma): clinicopathologic analysis of 90 cases . Am J Surg . 1981;142:459-463.Article
Irons GB, Weiland LH, Brown WL.  Paragangliomas of the neck: clinical and pathologic analysis of 116 cases . Surg Clin North Am . 1977;57: 575-583.
Lack EE, Cubilla AL, Woodruff JM, Farr HW.  Paragangliomas of the head and neck region: a clinical study of 69 patients . Cancer . 1977;39:397-409.Article
Sato T, Saito H, Yoshinaga K, Shibota Y, Sagano N.  Concurrence of carotid body tumor and pheochromocytoma . Cancer . 1974;34:1787-1795.Article
Rosen IB, Palmer JA, Goldberg M, Mustard RA.  Vascular problems with CBT . Am J Surg . 1981;142:459-463.Article
Harrison DFN.  Unusual tumors . In: Suen JY, Meyers EV, eds. Cancer of the Head and Neck . New York, NY: Churchill Livingstone; 1981:663.
Sykes JM, Ossoff RH.  Paragangliomas of the head and neck . Otolaryngol Clin North Am . 1986;19:755-767.
Kyriakos M.  Pathology of selected soft tissue tumors of the head and neck . In: Thawley SE, Panje WR, eds. Comprehensive Management of Head and Neck Tumors . Philadelphia, Pa: WB Saunders Co; 1987;2:1264-1265.
Chandry AP.  A nonfunctioning paraganglioma of the vagus nerve: an ultrastructural study . Cancer . 1979;43:1689-1701.Article
Mitchell DC, Clyne CAC.  Chemodectomas of the neck: the response to radiotherapy . Br J Surg . 1985;72:903-905.Article
Glenner GG, Grimley PM.  Tumors of the extra-adrenal paraganglion system (including chemoreceptors) . In: Atlas of Tumor Pathology . Washington, DC: Armed Forces Institute of Pathology; 1974; 2 ( (pt 9) ):13-16.