http://pubs.jamanetwork.com/ en-us Wed, 12 Jun 2013 00:00:00 GMT Wed, 12 Jun 2013 16:43:50 GMT Silverchair editor@pubs.jamanetwork.com webmaster@pubs.jamanetwork.com http://pubs.jamanetwork.com/article.aspx?articleID=1695324 Wed, 12 Jun 2013 00:00:00 GMT Huoh KC, Chang KW. <span class="paragraphSection"><div class="boxTitle">Importance</div>Isotretinoin is frequently prescribed for the treatment of acne vulgaris. Among the numerous documented adverse effects, most common are xerostomia and cheilitis. Lip abscesses as a consequence of cheilitis present dramatically and may pose a diagnostic challenge.<div class="boxTitle">Observations</div>We present a case of a 15-year-old boy with a severe lip abscess requiring incision and drainage and hospital admission for intravenous antibiotic treatment of methicillin-resistant Staphylococcus aureus. We discuss the pathophysiologic characteristics of isotretinoin therapy and the likely causative role that the medication played in the development of the lip abscess.<div class="boxTitle">Conclusions and Relevance</div>Although rare, lip abscesses related to isotretinoin therapy present with substantial morbidity and should be promptly recognized. Misdiagnosis of mucositis and angioedema may delay appropriate therapy.</span> 1 2 10.1001/jamadermatol.2013.4066 http://pubs.jamanetwork.com/article.aspx?articleID=1695324