AMA Publishing Group: Acute Coronary Syndrome Topic Collection

Serotonin Reuptake Inhibitor Use, Depression, and Long-Term Outcomes After an Acute Coronary Syndrome: A Prospective Cohort Study

Rieckmann N, Kronish IM, Shapiro PA, et al. — Mon, 13 May 2013 00:00:00 GMT

Depression is highly prevalent among patients with coronary heart disease. Selective serotonin reuptake inhibitors (SSRIs) are recommended as first-line antidepressant treatments for this population. Whereas there is a long-standing notion that SSRIs may improve cardiac disease prognosis by inhibiting platelet aggregation, SSRI use may also worsen prognosis by increasing bleeding or increasing the risk for arrhythmia.

New Oral Anticoagulants in Acute Coronary Syndromes: What Does a Meta-analysis Tell Us?

Kwong JW, Yu C. — Mon, 13 May 2013 00:00:00 GMT

We read with interest the meta-analysis by Komócsi et al, which reported that the use of factor Xa and direct thrombin inhibitors in patients receiving antiplatelet therapy after an acute coronary syndrome (ACS) was associated with a substantial increase in major bleeding and moderate reduction in ischemic events. However, there are a few issues we would like to highlight.

New Oral Anticoagulants in Acute Coronary Syndromes: What Does a Meta-analysis Tell Us?—Reply

Komócsi A, Vorobcsuk A, Aradi D. — Mon, 13 May 2013 00:00:00 GMT

In reply