AMA Publishing Group: Frontotemporal Dementia Topic Collection http://pubs.jamanetwork.com/ en-us Sat, 01 Jun 2013 00:00:00 GMT Mon, 10 Jun 2013 16:45:12 GMT Silverchair editor@pubs.jamanetwork.com webmaster@pubs.jamanetwork.com TREM2 , Frontotemporal Dementia–Like Disease, Nasu-Hakola Disease, and Alzheimer Dementia: A Chicken and Egg Problem? http://pubs.jamanetwork.com/article.aspx?articleID=1696565 Sat, 01 Jun 2013 00:00:00 GMT Bianchin M, Abujamra A, Izquierdo I. <span class="paragraphSection">We read with great interest the article by Guerreiro et al on the loss of function of the triggering receptor expressed on myeloid cells 2 (TREM2) gene causing Nasu-Hakola disease (NHD) and some frontotemporal dementia (FTD)–like diseases. Recently, TREM2 allele variants were also found to be associated with Alzheimer disease (AD). However, NHD, FTD-like disease, and AD differ enormously regarding the mechanism of disease, clinical aspects, and neuropathological findings. How can these differences be conciliated?</span> 70 6 805 806 10.1001/jamaneurol.2013.453 http://pubs.jamanetwork.com/article.aspx?articleID=1696565