AMA Publishing Group: Hair Disorders Topic Collection

Indomethacin for Refractory Infantile Eosinophilic Pustular Folliculitis

Toyonaga E, Abe R, Moriuchi R, et al. — Fri, 01 Mar 2013 00:00:00 GMT

Eosinophilic pustular folliculitis (EPF) in infancy is a rare disease. In infantile EPF, the lesions tend to resolve spontaneously or to respond well to topical corticosteroid treatment. We present herein a case of infantile EPF that was resistant to topical corticosteroid but showed great improvement after administration of oral indomethacin.

A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib Alopecia Associated With Nilotinib Therapy

Hansen T, Little AJ, Miller JJ, et al. — Fri, 01 Mar 2013 00:00:00 GMT

Importance

Nilotinib, a recently approved multitargeted tyrosine kinase inhibitor targeting the BCR-Abl translocation involved in chronic myelogenous leukemia, reportedly produces alopecia according to the package insert, but clinical and histologic descriptions of the alopecia are lacking.

Observations

A 33-year-old woman with chronic myelogenous leukemia developed widespread alopecia involving scalp and body hair within weeks after starting nilotinib therapy. Biopsies revealed perifollicular lymphocytic inflammation and evidence of follicular injury but normal hair density, consistent with a nonscarring alopecia.

Conclusions and Relevance

Nilotinib therapy may induce perifollicular inflammation and widespread persistent alopecia. We present the first clinical and histologic description of this potential adverse effect. Further investigation into the underlying mechanism of this adverse effect may produce insights into the hair growth cycle as well as potential therapeutic targets.

Hair-Shaft Abnormality in a 7-Year-Old Girl—Quiz Case

Lünnemann L, Vogt A, Blume-Peytavi U, et al. — Fri, 01 Mar 2013 00:00:00 GMT

Hair-Shaft Abnormality in a 7-Year-Old Girl—Diagnosis

Fri, 01 Mar 2013 00:00:00 GMT