AMA Publishing Group: Photosensitivity Disorders Topic Collection http://pubs.jamanetwork.com/ en-us Sat, 01 Dec 2012 00:00:00 GMT Tue, 01 Jan 2013 00:50:56 GMT Silverchair editor@pubs.jamanetwork.com webmaster@pubs.jamanetwork.com A New Spectrum of Skin Toxic Effects Associated With the Multikinase Inhibitor Vandetanib http://pubs.jamanetwork.com/article.aspx?articleID=1485959 Sat, 01 Dec 2012 00:00:00 GMT Giacchero D, Ramacciotti C, Arnault J, et al. <span class="paragraphSection">Skin manifestations are among the most frequent adverse effects of targeted therapies. Hyperkeratosis and hand-foot skin reaction are observed with most raf and vascular endothelial growth factor (VEGF) inhibitors, whereas folliculitis is a hallmark of epidermal growth factor receptor (EGFR) blocking agents. Vandetanib (Zactima, ZD6474; AstraZeneca) is a multikinase inhibitor that targets EGFR, VEGF receptors 1, 2, and 3 and the RET (rearranged during transfection) receptor.</span> 148 12 1418 1420 10.1001/2013.jamadermatol.192 http://pubs.jamanetwork.com/article.aspx?articleID=1485959