AMA Publishing Group: Vascular Malformations Topic Collection http://pubs.jamanetwork.com/ en-us Fri, 01 Mar 2013 00:00:00 GMT Wed, 20 Mar 2013 21:47:41 GMT Silverchair editor@pubs.jamanetwork.com webmaster@pubs.jamanetwork.com Phymatous Transformation of Facial Cutaneous Vascular Malformations: Clues to Phyma Pathogenesis http://pubs.jamanetwork.com/article.aspx?articleID=1670775 Fri, 01 Mar 2013 00:00:00 GMT Voth H, Wenzel J, Bieber T, et al. <span class="paragraphSection">Phymas are benign tumors of the face caused by hypertrophy of sebaceous glands and connective tissue. They are pathognomonic for rosacea, a common centrofacial inflammatory dermatosis of unknown origin. In spite of various factors that have been implicated in its etiopathology, including genetic susceptibility, vascular disturbances, dysregulation of the innate immune response, dermal matrix degeneration, actinic damage, and microbial organisms, the exact pathogenesis of rosacea and its different clinical manifestations remains unknown.</span> 149 3 368 369 10.1001/jamadermatol.2013.1213 http://pubs.jamanetwork.com/article.aspx?articleID=1670775