Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial

Mikael Fink Vallentin, MD; Asger Granfeldt, MD, PhD, DMSc; Carsten Meilandt, BSc; et al

Original Investigation | November 30, 2021

Explore Our Publications

JAMA
JAMA

Explore the latest in medicine including coronavirus (COVID-19) science, blood pressure guidelines, sepsis definitions, autism and cancer science, and more.

Home | New Online

JAMA Network Open
JAMA Network Open

Explore the latest research in hypertension, diabetes, stroke, dementia, machine learning, and more all completely free and open access.

Home | New Online

JAMA Cardiology
JAMA Cardiology

Explore the latest advances in PCI and device therapy, treatment of myocardial infarction, dyslipidemia, heart failure, afib & rhythm disorders, TAVR, and more.

Home | New Online

JAMA Dermatology
JAMA Dermatology

Explore the latest treatments for vitiligo, hidradenitis suppurativa, lichen sclerosus, melanoma, cosmetic dermatology, and more.

Home | New Online

JAMA Health Forum
JAMA Health Forum

Explore the latest in national and global health policy, including health care pricing, delivery, access, quality, safety, equity, and reform.

Home | New Online

JAMA Internal Medicine
JAMA Internal Medicine

Explore the latest in medicine including high-value care, levothyroxine timing, gabapentin for alcohol withdrawal, and more.

Home | New Online

View All Journals
JAMA Neurology
JAMA Neurology

Explore the latest in brain science including dementia, traumatic brain injury, cerebellar stroke, restless arms, herpes pain, and more.

Home | New Online

JAMA Oncology
JAMA Oncology

Explore the latest in cancer science including checkpoint inhibitors, DCIS, breast prostate and lung cancer treatment, aspirin prevention, biomarkers, and more.

Home | New Online

JAMA Ophthalmology
JAMA Ophthalmology

Explore the latest in vision science including causes & treatment of cataract, glaucoma, retinal disorders, and more.

Home | New Online

JAMA Otolaryngology – Head & Neck Surgery
JAMA Otolaryngology – Head & Neck Surgery

Explore the latest in management of tonsillitis, nystagmus, fistulae, and other head and neck disorders.

Home | New Online

JAMA Pediatrics
JAMA Pediatrics

Explore the latest in child health including food and nutrition, Kawasaki disease and C difficile, effects of media, and more.

Home | New Online

JAMA Psychiatry
JAMA Psychiatry

Explore the latest science of anxiety, autism, depression, OCD, psychosis, psychotherapy, schizophrenia, and more.

Home | New Online

JAMA Surgery
JAMA Surgery

Explore the latest techniques in bariatric surgery, enterocutaneous fistula and hernia repair, minimally invasive surgery, and more.

Home | New Online

Special Communications

Burden of Neurological Disorders Across the US From 1990-2017

This Global Burden of Disease study estimates changes in prevalence of major neurological disorders in the US by age and sex between 1990 and 2017.

Article

FDA Approval and Regulation of Pharmaceuticals, 1983-2018

A description of changes in the role and authority of the FDA and in the number of drugs the FDA has approved from 1983 to 2018.

Article

Global Burden of Cancer, 1990 to 2017

This systematic analysis describes cancer burden for 29 cancer groups across 195 countries from 1990 through 2017 to provide data needed for cancer control planning.

Article

View more
Global Burden of Skin Disease, 1990-2017

This cohort study reports the trends and variations in skin and subcutaneous diseases, along with malignant melanoma and keratinocyte carcinoma, in the 50 states and the District of Columbia for the past 3 decades.

Article

Global Mortality From Firearms, 1990-2016

This population epidemiology study estimates national rates of firearm homicide and suicide and unintentional gun deaths in 195 countries and territories from 1990 to 2016.

Article

Health Care Spending in the United States and Other High-Income Countries

This Special Communication analyzes data primarily from 2013-2016 to compare potential drivers of health care spending in the United States with those of 10 other high-income countries.

Article

Life Expectancy and Mortality Rates in the United States, 1959-2017

This population epidemiology study uses data from the National Center for Health Statistics and the US Mortality Database to assess changes and state-level trends in US life expectancy and mortality rates from 1959 to 2017, and to identify potential contributing factors.

Article

Medical Marketing in the United States, 1997-2016

A description of spending on marketing of prescription drugs, disease awareness, and health and laboratory services in the US between 1997 and 2016.

Article

Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter

Practices that promote clinician presence and connection during patient visits: preparation and listening with intent, agreeing on what matters most, connecting with the patient’s story, and exploring...

Article

United States Health Care Reform: Progress to Date and Next Steps

In this Special Communication, President Barack Obama reviews the Affordable Care Act: why he pursued it, what it has effected, and how the health care system can still be improved.

Article

The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States

Trends in mortality, life expectancy, and prevalence associated with most common diseases and disease and mortality risk factors in the United States between 1990 and 2016.

Article

The Burden of Cardiovascular Diseases Among US States, 1990-2016

This study using the Global Burden of Disease methodology quantifies and describes levels and trends of lost health due to cardiovascular disease within the United States from 1990 to 2016 as well as risk factors driving these changes.

Article

Waste in the US Health Care System: Estimated Costs and Potential for Savings

This Special Communication uses a systematic literature review to update previous dollar estimates of waste in the US health care system attributable to failure of care delivery and coordination, low-value care, price inflation, fraud, and administrative complexity.

Article

Featured

Patient Information Patient Information Patient Information
For Patients

Explore the latest patient information from JAMA Network, including easy-to-understand information about prevention and management of common illnesses

Collection

Podcasts from the JAMA Network Podcasts from the JAMA Network Podcasts from the JAMA Network
JAMA Network Audio

Editors' summaries, author interviews, and more from podcasts across 12 JAMA Network journals. Listen and subscribe now.

Collection

2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults
Hypertension

A collection of articles and resources on the epidemiology, diagnosis, and management of high blood pressure.

Home | JNC8 Guidelines

View more
Clinical Crosswords from JAMA Clinical Crosswords from JAMA Clinical Crosswords from JAMA
Clinical Crosswords from JAMA

Clinically themed interactive crossword puzzles from JAMA created by New York Times crossword authors.

Collection

Events and Conferences Events and Conferences Events and Conferences
Conference Publications

A collection of JAMA Network articles published to coincide with specialty society conferences.

Collection

Deep Learning and Artificial Intelligence in Health Care Deep Learning and Artificial Intelligence in Health Care Deep Learning and Artificial Intelligence in Health Care
Deep Learning and Artificial Intelligence in Health Care

A collection of resources about advances in artificial intelligence in health care and medicine.

Collection

JAMA Network Collection of Articles About Opioids JAMA Network Collection of Articles About Opioids JAMA Network Collection of Articles About Opioids
CDC Guideline for Prescribing Opioids for Chronic Pain, 2016

Read the 2016 guideline from the Centers for Disease Control and Prevention

Guideline | Collection

Consensus Definitions for Sepsis and Septic Shock Consensus Definitions for Sepsis and Septic Shock Consensus Definitions for Sepsis and Septic Shock
Consensus Definitions for Sepsis and Septic Shock from JAMA Network

Read The Third International Consensus Definitions for Sepsis and Septic Shock

Guideline | Collection

Health Systems and Recruitment Advertising Health Systems and Recruitment Advertising Health Systems and Recruitment Advertising
Health Systems & Recruitment Advertising

Helping you achieve your advertising and recruitment goals. Explore our consultative and strategic media options today

Website

Art and Images in Psychiatry Art and Images in Psychiatry Art and Images in Psychiatry
Art and Images in Psychiatry

A gallery of fine art representations of mental health and illness

Collection

JAMA Insights: Genomics and Precision Health JAMA Insights: Genomics and Precision Health JAMA Insights: Genomics and Precision Health
Genomics and Precision Health

An online resource to help clinicians and the public understand the latest in precision medicine

Collection

Statins for Primary Prevention of Cardiovascular Disease Statins for Primary Prevention of Cardiovascular Disease Statins for Primary Prevention of Cardiovascular Disease
2016 recommendation from USPSTF on statins for primary prevention of cardiovascular disease

Read the 2016 recommendation from the United States Preventive Services Task Force

Guideline | Collection

Screening for Colorectal Cancer Screening for Colorectal Cancer Screening for Colorectal Cancer
2016 recommendation from USPSTF on screening for colorectal cancer

Read the 2016 recommendation from the United States Preventive Services Task Force

Guideline | Collection

JAMA Network Open - Open Access Medical Research and Commentary JAMA Network Open - Open Access Medical Research and Commentary JAMA Network Open - Open Access Medical Research and Commentary
JAMA Network Open

JAMA Network Open publishes original research and commentary on clinical care, health policy, and global health

Website | Editorial

The Association Between Income and Life Expectancy in the United States, 2001-2014 The Association Between Income and Life Expectancy in the United States, 2001-2014 The Association Between Income and Life Expectancy in the United States, 2001-2014
The Association Between Income and Life Expectancy in the United States from JAMA Network

Read the analysis of US income and mortality data since 2001

Guideline | Collection

Breast Cancer Screening for Women at Average Risk Breast Cancer Screening for Women at Average Risk Breast Cancer Screening for Women at Average Risk
Breast Cancer Screening 2015 Guideline Update from the American Cancer Society

The latest recommendations about breast cancer screening from the American Cancer Society in their 2015 Guideline Update

Guideline | Collection

Ethical Principles for Medical Research Ethical Principles for Medical Research Ethical Principles for Medical Research
Ethical Principles for Medical Research

The Nuremberg Code, Declaration of Helsinki, and Declaration of Geneva provide a set of ethical principles regarding human experimentation and clinical care

Declaration | Collection

Screening for Depression in Adults Screening for Depression in Adults Screening for Depression in Adults
2016 recommendation from USPSTF on screening for depression in adults

Read the 2016 recommendation from the United States Preventive Services Task Force

Guideline | Collection

Apply now for the Morris Fishbein Fellowship in Medical Editing Apply now for the Morris Fishbein Fellowship in Medical Editing Apply now for the Morris Fishbein Fellowship in Medical Editing
The Morris Fishbein Fellowship in Medical Editing

A unique one-year fellowship opportunity offered by JAMA to introduce physicians to all facets of editing and publishing a major medical journal

Website