This Medical Letter review summarizes the indications, risks, and benefits of bezlotoxumab, a monoclonal antibody to be used with antibacterial drug treatment to reduce recurrence of Clostridium difficile infection in adults at high risk.
A 28-year-old man develops abdominal discomfort and frequent bowel movements with a positive PCR test for Clostridium difficile toxin 6 weeks after treatment with metronidazole for C difficile infection. What would you do next?
This Arts and Medicine essay reviews how comedian Tig Notaro mined humor out of her C difficile infection, breast cancer diagnosis, and subsequent bilateral mastectomy and discusses the role of comedy in illness and health care.
This randomized noninferiority trial assessed whether FMT using frozen stool is noninferior to transplantation using fresh stool in resolving diarrhea among adult patients with recurrent or refractory Clostridium difficile infection.
This phase 2 randomized trial reports that spores of nontoxigenic Clostridium difficile strain M3 were well tolerated, appeared to be safe, and reduced recurrence of C difficile infection (CDI) among patients who had previously had CDI treated with metronidazole or vancomycin.
This systematic review summarizes the diagnostic approaches for Clostridium difficile infection and evaluates which therapeutic approaches should be used.
This open-label, single-group feasibility study among patients with relapsing C difficile infection provides data on adverse events and rates of diarrhea resolution following fecal microbiota transplantation using frozen encapsulated inoculum from unrelated donors.
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