This randomized trial compares the effect of a program to promote systematic intensive care unit (ICU) admission vs standard practice on 6-month mortality in critically ill elderly patients.
This Viewpoint summarizes recommendations from a specialist roundtable meeting about requirements for and appropriate use of extracorpeal organ support for patients with critical illness or organ failure.
This randomized clinical trial examines whether ganciclovir prophylaxis reduces plasma interleukin 6 levels in cytomegalovirus-seropositive adults who are critically ill.
This study assesses the 6-month discriminative accuracy of patient mortality and functional outcome predictions made by intensive care unit (ICU) physicians and nurses at the time of ICU admission.
This Clinical Evidence Synopsis summarizes a 2016 update of a Cochrane review of clinical trials comparing the effects of antifungal drugs on prevention of mortality and invasive fungal infection in critically ill patients without neutropenia.
This cohort study compares the accuracy of the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score, quick SOFA score, and Systemic Inflammatory Response Syndrome criteria for predicting in-hospital mortality or prolonged length of stay among adults admitted to the ICU with suspected infection in Australia and New Zealand.
This observational study quantifies the risk to hospital inpatients associated with patients on the same ward experiencing critical illness.
This study summarizes transfusion recommendations from the AABB (formerly known as the American Association of Blood Banks) based on randomized clinical trials.
This randomized clinical trial compares the effects of high-flow conditioned oxygen therapy vs noninvasive ventilation (NIV) on postextubation respiratory failure and reintubation among critically ill adult patients.
This randomized clinical trial compares the effects of micafungin vs placebo on 28-day fungal infection–free survival among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure.
This Rational Clinical Examination systematic review summarizes studies that evaluated the diagnostic accuracy of tests for predicting fluid responsiveness in hemodynamically unstable adult patients to better identify patients who would benefit from further fluid administration.
This randomized clinical trial compares the effects of early vs delayed initiation of renal replacement therapy on 90-day all-cause mortality among critically ill patients with AKI.
This study used survey and qualitative methods to characterize the frequency of and reasons for discordance in estimates of prognosis of critically ill patients made by physicians and surrogate decision makers.
This cluster randomized trial investigated the effects of a quality improvement intervention comprising checklists, goal setting, and clinician follow-up vs routine care on mortality among adults in Brazilian intensive care units.
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