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  • JAMA March 2, 2011

    Figure 4: Comparison of High-Mobility Group A1 (HMGA1) and Insulin Receptor (INSR) Protein Expression, and 125I-insulin Binding in Transformed Lymphoblasts

    Studies were performed in Epstein-Barr virus–transformed lymphoblasts from controls (n = 20) and both patients with nonvariant type 2 diabetes mellitus (DM) (n = 20) and IVS5-13insC variant type 2 DM (n = 20) before and after transfection with expression vectors containing the HMGA1 complementary DNA in either the sense or antisense orientations. B, Results are presented as mean and 95% confidence intervals for 3 separate assays. P < .001 for comparison between patients with carrier type 2 DM and both nondiabetic controls and patients with nonvariant wild-type type 2 DM. C, Results are presented as mean and 95% confidence intervals. P = .03 for comparison with patients with nonvariant wild-type type 2 DM. P = .002 for comparison with patients with nonvariant wild-type type 2 DM.
  • JAMA May 25, 2005

    Figure 2: Relative Risk of Multiple Sclerosis According to Anti-VCA IgG and Anti-EBNA IgG Antibody Titers

    VCA indicates viral capsid antigen; EBNA, Epstein-Barr nuclear antigen. Epstein-Barr virus titer levels were missing for 1 control.
  • Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis

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    JAMA. 2005; 293(20):2496-2500. doi: 10.1001/jama.293.20.2496
  • JAMA January 26, 2005

    Figure: Proportion of Controls With Past Infectious Mononucleosis or Very High Epstein-Barr Virus (EBV) IgG Titers by Infant Sibling Exposure in Early Life

    The tests for trend have been adjusted for history of having been breastfed or ever smoked. Very high composite EBV IgG titer = (EBV nuclear antigen IgG>300 units + EBV capsid antigen IgG>300 units).
  • Exposure to Infant Siblings During Early Life and Risk of Multiple Sclerosis

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    JAMA. 2005; 293(4):463-469. doi: 10.1001/jama.293.4.463
  • JAMA April 21, 2004

    Figure 1: Comparison of Epstein-Barr Virus Serological Results Between Pediatric Multiple Sclerosis Patients and Controls

    Epstein-Barr virus (EBV) serological results in children with clinically definite multiple sclerosis, emergency department (ED) controls, and bone marrow transplant (BMT) controls. Patients were classified as "remotely infected" if EBV antibodies against both capsid (VCA) and nuclear (EBNA) antigens (irrespective of early antigens [EA]) were detected; "recently infected" if antibodies against VCA and EA (but not EBNA) were detected; and "EBV-negative" if antibodies against all 3 EBV antigens were absent. Children with multiple sclerosis were more likely to be positive for remote EBV infection than ED (P<.001) or BMT controls (P<.001) and less likely to be EBV-negative than ED (P = .04) or BMT controls (P<.001).
  • JAMA April 21, 2004

    Figure 2: Comparison of Seropositivity for Common Childhood Viruses Between Children With Multiple Sclerosis and Healthy Age-Matched Controls

    Epstein-Barr virus (EBV) (remote infection), herpes simplex virus (HSV), parvovirus B19, varicella zoster (VZV), and cytomegalovirus (CMV) serological results in multiple sclerosis patients and emergency department (ED) controls. Children with multiple sclerosis were more likely to be positive for remote EBV infection than ED controls (*P<.001) and less likely to be HSV-positive (†P = .003). There was no difference in seropositivity for parvovirus, VZV, or CMV between the multiple sclerosis and ED cohorts.
  • Epstein-Barr Virus in Pediatric Multiple Sclerosis

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    JAMA. 2004; 291(15):1875-1879. doi: 10.1001/jama.291.15.1875
  • Multiple Sclerosis and Epstein-Barr Virus

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    JAMA. 2003; 289(12):1533-1536. doi: 10.1001/jama.289.12.1533
  • JAMA December 26, 2001

    Figure 2: Temporal Relation Between Anti-EBV Serum Antibodies and MS Onset in 144 Cases

    EBV indicates Epstein-Barr virus; MS, multiple sclerosis; VCA, viral capsid antigen; EBNA, Epstein-Barr nuclear antigen; and EA-D, diffuse early antigen complex.
  • Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study

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    JAMA. 2001; 286(24):3083-3088. doi: 10.1001/jama.286.24.3083
  • JAMA February 3, 1999

    Figure 2: EBV-Specific Serologic Responses in Infectious Mononucleosis

    Serologic responses to common Epstein-Barr virus (EBV) antigens after primary EBV infection. VCA indicates viral capsid antigen; EA, early antigen (diffuse [anti-D]); and EBNA, anti-EBV nuclear antigen. Figure adapted courtesy of the Scandinavian University Press.
  • Ketosis-Prone Type 2 Diabetes Mellitus and Human Herpesvirus 8 Infection in Sub-Saharan Africans

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    JAMA. 2008; 299(23):2770-2776. doi: 10.1001/jama.299.23.2770
  • Risk Factors for Pediatric Human Immunodeficiency Virus–Related Malignancy

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    JAMA. 2003; 289(18):2393-2399. doi: 10.1001/jama.289.18.2393
  • Erythematous Rash Following Hematopoietic Stem Cell Transplantation

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    JAMA. 2017; 318(18):1822-1823. doi: 10.1001/jama.2017.14949

    A 66-year-old man developed noninfectious fever and rash after autologous HSCT. Chest computed tomography showed ground-glass and consolidative lung opacities; skin punch biopsy showed vacuolar change and superficial perivascular mononuclear cell infiltrate. What would you do next?

  • JAMA December 20, 2016

    Figure 1: Analytic Framework and Key Questions

    Evidence reviews for the US Preventive Services Task Force (USPSTF) use an analytic framework to visually display the key questions that the review will address to allow the USPSTF to evaluate the effectiveness and safety of a preventive service. The questions are depicted by linkages that relate interventions and outcomes. A dashed line indicates health outcomes that follow an intermediate outcome. HSV indicates herpes simplex virus. Further details are available from the USPSTF procedure manual.aStudies that screen using an HSV-2 serologic test alone or a paired (HSV-1 and HSV-2) serologic test will be included if they meet other eligibility criteria; however, only the accuracy of test characteristics related to HSV-2 serologic tests will be evaluated.bKey question 7 will be addressed only if there is insufficient literature for key questions 1 and 5 but sufficient literature for key question 4.
  • Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial

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    JAMA. 2017; 318(8):731-740. doi: 10.1001/jama.2017.10569

    This randomized clinical trial examines whether ganciclovir prophylaxis reduces plasma interleukin 6 levels in cytomegalovirus-seropositive adults who are critically ill.

  • Serologic Screening for Genital Herpes: An Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

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    JAMA. 2016; 316(23):2531-2543. doi: 10.1001/jama.2016.17138

    This Evidence Report to support the 2016 update of the US Preventive Services Task Force Recommendation Statement on serologic screening for genital herpes summarizes evidence about screening for and the effectiveness of antiviral medication to prevent asymptomatic genital herpes infection.

  • Infectious Mononucleosis

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    JAMA. 2016; 315(14):1532-1532. doi: 10.1001/jama.2016.2474
  • Does This Patient Have Infectious Mononucleosis? The Rational Clinical Examination Systematic Review

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    JAMA. 2016; 315(14):1502-1509. doi: 10.1001/jama.2016.2111

    This Rational Clinical Examination systematic review summarizes the diagnostic accuracy of physical examination and laboratory findings for diagnosing infectious mononucleosis in adolescent and young adults.