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  • Association Between Sentinel Lymph Node Excision With or Without Preoperative SPECT/CT and Metastatic Node Detection and Disease-Free Survival in Melanoma

    Abstract Full Text
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    JAMA. 2012; 308(10):1007-1014. doi: 10.1001/2012.jama.11030
    Stoffels and coauthors compared metastatic node detection and disease-free survival using single-photon emission computed tomography/computed tomography-aided sentinel lymph node excision (SLNE) vs standard SLNE in 464 patients with melanoma from a single institution.
  • JAMA September 12, 2012

    Figure 1: Kaplan-Meier Curve With the SPECT/CT-Specific Disease-Free Survival Over 48 Months

    SPECT/CT indicates single-photon emission computed tomography/computed tomography.
  • JAMA September 12, 2012

    Figure 2: Preoperative Lymphoscintigraphy, SPECT/CT, and Low-Dose CT Imaging of 3 Representative Study Patients

    SPECT/CT indicates single-photon emission computed tomography/computed tomography. The red lines indicate patients’ body contour. A, Patient with a retroauricular melanoma. SPECT/CT in the coronal and axial planes shows 1 cranial sentinel lymph node (SLN) (blue arrowheads) and 1 caudal SLN (black arrowhead). B, Patient with a malignant melanoma on the right side of the torso. SPECT/CT in the axial plane of the axillary region shows 1 SLN (blue arrowhead). SPECT/CT in axial plane of the scapular region shows 1 SLN next to the coracoid (black arrowhead) and another SLN in the cranial axillary region (blue arrowhead). C, Patient with a malignant melanoma on the right foot. SPECT/CT in the coronal and axial planes of the popliteal region shows 1 SLN (blue arrowheads). SPECT/CT in the coronal and axial planes of the inguinal region shows 4 SLNs (black arrowheads).
  • Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure: The FOCUS-CCTRN Trial

    Abstract Full Text
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    JAMA. 2012; 307(16):1717-1726. doi: 10.1001/jama.2012.418
    Perin and coauthors, for the Cardiovascular Cell Therapy Research Network, investigated the effects of transendocardial-delivered bone marrow mononuclear cells (BMCs) in 61 patients receiving BMCs and 31 patients receiving placebo who had chronic ischemic heart failure.
  • Intramyocardial Bone Marrow Cell Injection for Chronic Myocardial Ischemia: A Randomized Controlled Trial

    Abstract Full Text
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    JAMA. 2009; 301(19):1997-2004. doi: 10.1001/jama.2009.685
  • JAMA May 20, 2009

    Figure 2: Improvements in Segments With Inducible Myocardial Ischemia as Assessed by SPECT

    Each additional spoke on the data markers denotes another patient with the same number of ischemic segments. In the bone marrow cell group, there is a larger decrease in segments with inducible ischemia than in the placebo group (P < .001). Square data markers with error bars are the mean (SD) number of ischemic myocardial segments per patient for each group.
  • JAMA June 15, 2005

    Figure 1: Flow of Study Participants

    STEMI indicates ST-segment elevation myocardial infarction; SPECT, single-photon emission computed tomography.
  • JAMA January 26, 2005

    Figure: Practical Algorithm for Management of Patients With Symptoms and Nonobstructive Coronary Artery Disease

    MRI indicates magnetic resonance imaging; PET, positron emission tomography; CAD, coronary artery disease. Vascular function studies include coronary flow reserve and coronary acetylcholine testing. All patients should have cardiac risk factor management, as appropriate, according to the American Heart Association/American College of Cardiology guidelines.*Which specific test to obtain depends on patient and institutional circumstances. In some cases serial tests may be needed (eg, first a stress electrocardiogram or echocardiogram followed by gated single-photon emission computed tomography [SPECT]).
  • JAMA February 25, 2004

    Figure 1: Technetium Tc 99m Single-Photon Emission Computed Tomography Images Recorded in 2 Patients 1 Week After Acute Anterior Myocardial Infarction

    White arrowheads in images from patient 1 indicate a large perfusion defect (38%) of the left ventricle (large myocardial infarction). Black arrowheads in images from patient 2 indicate a small perfusion defect (6%) of the left ventricle (small myocardial infarction).
  • JAMA February 25, 2004

    Figure 2: Flow of Study Participants

    CABG indicates coronary artery bypass graft surgery; PTCA, percutaneous transluminal coronary angioplasty; SPECT, single-photon emission computed tomography.
  • JAMA January 21, 2004

    Figure 2: Neuroimaging Scans in Normal Controls and Patients With Parkinson Disease

    Top, fluorodopa with positron emission tomography in healthy controls and patients with Parkinson disease (provided courtesy of and with permission from David Brooks, MD). Bottom, 2β-carbomethoxy-3β-[4-iodophenyl]tropane (β-CIT) with single-photon emission computed tomography uptake in healthy controls and patients with Parkinson disease (provided courtesy of and with permission from Ken Marek, MD). Note that in Parkinson disease, striatal uptake of these markers is asymmetrically reduced, more so in the posterior portion of the putamen. Note also that with advancing disease, uptake of these indices is further reduced, which can be quantified and serve as a surrogate marker of disease progression.
  • JAMA April 3, 2002

    Figure 2: Progessive Loss of Striatal β-CIT Uptake

    β-CIT indicates 2β-carboxymethoxy-3β(4-iodophenyl)tropane. Single-photon emission computed tomography (SPECT) [123I]β-CIT images of progressive striatal dopamine transporter loss during the 46-month evaluation period for a representative patient. Loss of activity is more marked in the putamen than in the caudate. Levels of SPECT activity are color-encoded from low (black) to high (yellow/white).
  • Exercise Echocardiography or Exercise SPECT Imaging? A Meta-analysis of Diagnostic Test Performance

    Abstract Full Text
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    JAMA. 1998; 280(10):913-920. doi: 10.1001/jama.280.10.913
  • JAMA September 9, 1998

    Figure: Exercise Echocardiography or Exercise SPECT Imaging? A Meta-analysis of Diagnostic Test Performance

    Figure 1.—Panel A shows summary receiver operating characteristic (SROC) curves for exercise single-photon emission computed tomography (SPECT) based on a model comparing exercise echocardiography (ECHO) and exercise SPECT. Panel B shows SROC curves for exercise ECHO based on model comparing exercise ECHO and exercise SPECT. Panel C shows SROC curves for exercise testing without adjunct imaging based on a model comparing exercise ECHO and exercise electrocardiography. In all panels, the horizontal axis represents the false-positive ratio (1 − specificity) and the vertical axis the true-positive ratio (sensitivity). The base case is adjusted to a population aged 59 years, publication year 1993, and a setting including known or suspected coronary artery disease (CAD) in half of the cases. Additional SROC curves represent the best case, which is adjusted to age 55 years, publication year 1990, and a setting including known or suspected CAD in all cases, and worst case, which is adjusted to age 65 years, publication year 1995, and a setting with suspected CAD only in all cases.
  • Single-Photon Emission Computed Tomography (SPECT): Applications and Potential

    Abstract Full Text
    JAMA. 1990; 263(4):561-564. doi: 10.1001/jama.1990.03440040100036
  • Dementias Appear to Have Individual Profiles in Single Photon Emission Computed Tomography

    Abstract Full Text
    JAMA. 1989; 261(7):965-968. doi: 10.1001/jama.1989.03420070015004
  • Muscarinic Acetylcholine Receptors in Alzheimer's Disease: In Vivo Imaging With Iodine 123—Labeled 3-Quinuclidinyl-4-Iodobenzilate and Emission Tomography

    Abstract Full Text
    JAMA. 1985; 254(21):3063-3066. doi: 10.1001/jama.1985.03360210079035
  • Neurological Surgery

    Abstract Full Text
    JAMA. 1990; 263(19):2658-2659. doi: 10.1001/jama.1990.03440190114060
  • Machines and People: Who and What Are Important?

    Abstract Full Text
    JAMA. 1984; 252(9):1181-1182. doi: 10.1001/jama.1984.03350090057023
  • Nuclear Medicine

    Abstract Full Text
    JAMA. 1995; 273(21):1697-1698. doi: 10.1001/jama.1995.03520450067034