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  • Effect of Tailored Dose-Dense Chemotherapy vs Standard 3-Weekly Adjuvant Chemotherapy on Recurrence-Free Survival Among Women With High-Risk Early Breast Cancer: A Randomized Clinical Trial

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    JAMA. 2016; 316(18):1888-1896. doi: 10.1001/jama.2016.15865

    This randomized clinical trial compares the effects of tailored dose-dense adjuvant chemotherapy vs standard adjuvant chemotherapy on recurrence-free survival in women with high-risk early breast cancer.

  • Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma

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    JAMA. 2016; 315(15):1600-1609. doi: 10.1001/jama.2016.4059

    This study pools patient cohorts from randomized and nonrandomized studies to investigate associations between pembrolizumab therapy and tumor response among patients with advanced melanoma with and without prior ipilimumab therapy.

  • Ipilimumab Plus Sargramostim vs Ipilimumab Alone for Treatment of Metastatic Melanoma: A Randomized Clinical Trial

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    JAMA. 2014; 312(17):1744-1753. doi: 10.1001/jama.2014.13943

    This phase 2 randomized clinical trial comparing treatment with sargramostim plus ipilimumab, compared to ipilimumab alone in patients with unresectable stage III or IV malanoma, reports longer overall survival and lower toxicity, but no difference in progression-free survival.

  • Antiretroviral Treatment of Adult HIV Infection: 2014 Recommendations of the International Antiviral Society–USA Panel

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    JAMA. 2014; 312(4):410-425. doi: 10.1001/jama.2014.8722

    Günthard and coauthors report the 2014 recommendations of the International Antiviral Society–USA Panel on antiretroviral treatment of adult human immunodeficiency virus (HIV) infection.

  • Adjuvant Chemotherapy With Gemcitabine and Long-term Outcomes Among Patients With Resected Pancreatic Cancer: The CONKO-001 Randomized Trial

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    JAMA. 2013; 310(14):1473-1481. doi: 10.1001/jama.2013.279201

    To analyze whether previously reported improvement in disease-free survival with adjuvant gemcitabine therapy translates into improved overall survival, Oettle and coauthors conducted a multicenter, open-label, phase 3 randomized trial to evaluate the efficacy and toxicity of gemcitabine in patients with pancreatic cancer after complete tumor resection.

  • Antiretroviral Treatment of Adult HIV Infection: 2012 Recommendations of the International Antiviral Society–USA Panel

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    JAMA. 2012; 308(4):387-402. doi: 10.1001/jama.2012.7961
    Thompson and coauthors provide an update of guidelines recommended by the International Antiviral Society–USA Panel on antiretroviral therapy for HIV-infected adults in developed-world settings.
  • Chemical Toxicity Screening

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    JAMA. 2012; 307(4):351-351. doi: 10.1001/jama.2012.6
  • Genomic Technology Applied to Pharmacological Traits

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    JAMA. 2011; 306(6):652-653. doi: 10.1001/jama.2011.1125
  • A National Registry for Healthy Volunteers in Phase 1 Clinical Trials

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    JAMA. 2011; 305(12):1236-1237. doi: 10.1001/jama.2011.354
  • Biomedical Informatics in the Education of Physicians

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    JAMA. 2010; 304(11):1227-1228. doi: 10.1001/jama.2010.1262
  • Oil Leak Health Effects

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    JAMA. 2010; 304(6):628-628. doi: 10.1001/jama.2010.1076
  • Experts Focus on Identifying, Mitigating Potential Health Effects of Gulf Oil Leak

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    JAMA. 2010; 304(6):621-624. doi: 10.1001/jama.2010.1053
  • Antiretroviral Treatment of Adult HIV Infection: 2010 Recommendations of the International AIDS Society–USA Panel

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    JAMA. 2010; 304(3):321-333. doi: 10.1001/jama.2010.1004
  • Supplements Scrutinized

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    JAMA. 2010; 304(2):148-148. doi: 10.1001/jama.2010.877
  • JAMA January 13, 2010

    Figure: Toxic Substances

    Efforts by the US Environmental Protection Agency to regulate chemicals for toxicity are hampered by existing laws, said the Government Accountability Office in a report.
  • Illnesses and Injuries Related to Total Release Foggers—Eight States, 2001-2006

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    JAMA. 2008; 300(22):2600-2602. doi: 10.1001/jama.300.22.2600
  • JAMA November 26, 2008

    Figure: Expression of the FMR1 Gene and Associated Clinical Disorders

    Expression of the fragile X mental retardation 1 (FMR1) gene depends on the length of the CGG repeat. Premutation alleles result in elevated mRNA levels (increased RNA synthesis). Within this CGG repeat range, the expanded CGG repeat in FMR1 mRNA partially blocks translation to an extent that depends on the size of the repeat. Full mutation alleles are generally hypermethylated and silenced, thus producing little or no mRNA or protein. The excess premutation mRNA is now believed to give rise to the premutation-specific disorders, fragile X–associated tremor/ataxia syndrome and primary ovarian insufficiency, and may also contribute to developmental delays, attention-deficit/hyperactivity disorder, or autism spectrum disorders in some children with the premutation. By contrast, fragile X syndrome is caused by the absence of the FMR1 mRNA and protein (FMRP). In the upper portion of the premutation CGG repeat range, mRNA toxicity and reduced FMRP levels may both contribute to clinical involvement. UTR indicates 5′ untranslated region.
  • JAMA August 6, 2008

    Figure 4: Cumulative Estimates of Time to Death and Regimen Change Due to Toxicity

    ART indicates antiretroviral therapy; CI, confidence interval; HR, hazard ratio; TB, tuberculosis. Error bars indicate 95% CIs.aAdjusted for age, sex, baseline CD4 cell count, and year of ART initiation.bAdjusted for age, sex, and baseline CD4 cell count.
  • JAMA March 26, 2008

    Figure: Health, Environmental Agencies Team Up to Develop New Plan for Toxicity Testing

    More than 1500 chemicals can be tested for toxicity in each of these dishes, allowing thousands to be screened within hours.
  • Fluorouracil vs Gemcitabine Chemotherapy Before and After Fluorouracil-Based Chemoradiation Following Resection of Pancreatic Adenocarcinoma: A Randomized Controlled Trial

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    JAMA. 2008; 299(9):1019-1026. doi: 10.1001/jama.299.9.1019