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Artificial Intelligence (AI)

A collection of articles and resources on clinical applications of large language models (LLMs) and other AI technologies.

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NEWS

Medical News & Perspectives

Physicians, Patients, and AI: Whose Humanity Is It, Anyway?

Rebecca Voelker, MSJ

Medical News & Perspectives

Google Health’s Clinical Chief Talks AI in Health Care

Rebecca Voelker, MSJ

Medical News in Brief

Trial: AI-Supported Mammography Screening Is Safe, Time-Saving

Emily Harris

Medical News in Brief

Study Tests Large Language Models’ Ability to Answer Clinical Questions

Emily Harris

Medical News in Brief

National Health Care Leaders Will Develop AI Code of Conduct

Emily Harris

News From the Food and Drug Administration

FDA Approves Artificial Intelligence Device for Guiding Regional Anesthesia

Howard D. Larkin

Health Agencies Update

New NIH Program for Artificial Intelligence in Research

Melissa Suran, PhD, MSJ

News From the Food and Drug Administration

US, Canada, and UK Collaborate on New Guidance for Machine Learning

Rebecca Voelker, MSJ

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RESEARCH

Original Investigation

Defining Oral Temperature Ranges in Outpatients Using an Unsupervised Learning Algorithm

Catherine Ley, PhD, Frederik Heath, MS et al.

Research Letter

Chatbot vs Medical Student Performance on Free-Response Clinical Reasoning Examinations

Eric Strong, MD, Alicia DiGiammarino, MS et al.

Research Letter

History of Present Illness Summaries Generated by a Chatbot and Senior Internal Medicine Residents

Ashwin Nayak, MD, MS, Matthew S. Alkaitis, MD, PhD et al.

Research Letter

Accuracy of a Generative Artificial Intelligence Model in a Complex Diagnostic Challenge

Zahir Kanjee, MD, MPH, Byron Crowe, MD et al.

Original Investigation

Comparing Physician and Chatbot Responses to Patient Questions

John W. Ayers, PhD, MA, Adam Poliak, PhD et al.

Research Letter

Appropriateness of Cardiovascular Disease Prevention Recommendations From Online Chat-Based AI Model

Ashish Sarraju, MD, Dennis Bruemmer, MD, PhD et al.

Research Letter

States’ Methods for Capturing and Reporting Local Responses to Suspected Nonfatal Drug Overdoses

Christian Johnson, MPH, Megan Catlin, MS et al.

Original Investigation

Accuracy of Stroke Risk Prediction Models by Race, Sex, and Age

Chuan Hong, PhD, Michael J. Pencina, PhD et al.

Original Investigation

Artificial Intelligence and Cognitive Behavioral Therapy for Chronic Back Pain

John D. Piette, MSc, PhD, Sean Newman, MS et al.

Original Investigation

External Validation of a Widely Implemented Sepsis Prediction Model in Hospitalized Patients

Andrew Wong, MD, Erkin Otles, MEng et al.

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REVIEW

Special Communication

Creation and Adoption of Large Language Models in Medicine

Nigam H. Shah, MBBS, PhD, David Entwistle, BS, MHSA et al.

Special Communication

Artificial Intelligence in Breast Cancer Screening

Kunal C. Potnis, BS, Joseph S. Ross, MD, MHS et al.

Users' Guides to the Medical Literature

How to Read Articles That Use Machine Learning

Yun Liu, PhD, Po-Hsuan Cameron Chen, PhD et al.

JAMA Guide to Statistics and Methods

On Deep Learning for Medical Image Analysis

Lawrence Carin, PhD, Michael J. Pencina, PhD

OPINION

Viewpoint

2023 Albert Lasker Basic Medical Research Award

John Jumper, PhD, Demis Hassabis, PhD

Viewpoint

Transformation of Undergraduate Medical Education in 2023

Bernard S. Chang, MD, MMSc

Viewpoint

Guiding Risk Adjustment Models Toward Machine Learning Methods

Gary E. Weissman, MD, MSHP, Karen E. Joynt Maddox, MD, MPH

Editorial

JAMA Call for Papers for AI in Medicine

Rohan Khera, MD, MS, Atul J. Butte, MD, PhD et al.

Editor's Note

Assessment of Chatbot Performance in Health Sciences Research

Eric Ward, MD, Cary Gross, MD

Editorial

Guidance for Authors, Peer Reviewers, and Editors on Use of AI

Annette Flanagin, RN, MA, Jacob Kendall-Taylor, BA et al.

Viewpoint

Data Harmonization of COVID-19 Research in Pregnant and Pediatric Populations

Jessica L. Gleason, PhD, MPH, Robert Tamburro, MD, MSc et al.

Viewpoint

Artificial Intelligence in Clinical Diagnosis

Prathit A. Kulkarni, MD, Hardeep Singh, MD, MPH

Viewpoint

Use of Generative AI in Health Care and Liability Risks for Physicians and Safety Concerns for Patients

Mindy Duffourc, JD, BA, Sara Gerke, Dipl-Jur Univ, MA

Viewpoint

Health Care Privacy Risks of AI Chatbots

Genevieve P. Kanter, PhD, Eric A. Packel, JD

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SPECIALTY ARTIFICIAL INTELLIGENCE (AI)
Cardiology
Deep Learning for Cardiovascular Imaging JAMA Cardiology |
Social Media Users’ Response to Sudden Cardiac Arrest During Football Broadcast JAMA Network Open |
Using Social Media Platforms for the Greater Good JAMA Network Open |
Use of Wearable Devices in Individuals With or at Risk for CVD JAMA Network Open |
AI-Enabled Analysis of Statin-Related Topics and Sentiments on Social Media JAMA Network Open |
Use of Machine Learning to Identify Children with Kawasaki Disease JAMA Network Open |
Physiologic Monitoring Strategies in the Emergency Department JAMA Network Open |
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SPECIALTY ARTIFICIAL INTELLIGENCE (AI)
Dermatology
Diagnostic Performance of Dermatologists Cooperating With a CNN JAMA Dermatology |
AI Support Tool for Telemedicine JAMA Dermatology |
Checklist for Evaluation of Image-Based Artificial Intelligence Reports in Dermatology JAMA Dermatology |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Lack of Transparency and Potential Bias in AI Data Sets and Algorithms JAMA Dermatology |
Risk of Bias and Error From Data Sets Used for Dermatologic AI JAMA Dermatology |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
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SPECIALTY ARTIFICIAL INTELLIGENCE (AI)
Cardiology
Dermatology
Deep Learning for Cardiovascular Imaging JAMA Cardiology |
Diagnostic Performance of Dermatologists Cooperating With a CNN JAMA Dermatology |
Social Media Users’ Response to Sudden Cardiac Arrest During Football Broadcast JAMA Network Open |
AI Support Tool for Telemedicine JAMA Dermatology |
Using Social Media Platforms for the Greater Good JAMA Network Open |
Use of Wearable Devices in Individuals With or at Risk for CVD JAMA Network Open |
Checklist for Evaluation of Image-Based Artificial Intelligence Reports in Dermatology JAMA Dermatology |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
AI-Enabled Analysis of Statin-Related Topics and Sentiments on Social Media JAMA Network Open |
Lack of Transparency and Potential Bias in AI Data Sets and Algorithms JAMA Dermatology |
Use of Machine Learning to Identify Children with Kawasaki Disease JAMA Network Open |
Risk of Bias and Error From Data Sets Used for Dermatologic AI JAMA Dermatology |
Physiologic Monitoring Strategies in the Emergency Department JAMA Network Open |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
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Neurology
Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times JAMA Neurology |
Three-Dimensional Structural Phenotype of the Optic Nerve Head as a Function of Glaucoma Severity JAMA Ophthalmology |
Deep Learning Models to Classify and Monitor Scoliosis Using a Single Smartphone Photograph JAMA Network Open |
The New Era of Automated Electroencephalogram Interpretation JAMA Neurology |
Automated Interpretation of Clinical Electroencephalograms Using Artificial Intelligence JAMA Neurology |
Studying Healthy Psychosislike Experiences to Improve Illness Prediction JAMA Psychiatry |
Evaluation of Risk of Bias in Neuroimaging-Based AI Models for Psychiatric Diagnosis JAMA Network Open |
Accuracy of Stroke Risk Prediction Models by Race, Sex, and Age JAMA |
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Oncology
Using Race and Ethnicity in Lung Cancer Prediction Models JAMA Network Open |
Balancing Statistical Precision With Societal Goals to Reduce Health Disparities JAMA Network Open |
Trial: AI-Supported Mammography Screening Is Safe, Time-Saving JAMA |
Use of Artificial Intelligence Chatbots for Cancer Treatment Information JAMA Oncology |
Artificial Intelligence—From Starting Pilots to Scalable Privilege JAMA Oncology |
Assessment of AI Chatbot Responses to Top Searched Queries About Cancer JAMA Oncology |
Multilevel Model to Identify Patients at Risk for Delay in Starting Cancer Treatment JAMA Network Open |
Deep Learning for Sarcopenia Analysis in Head and Neck Cancer JAMA Network Open |
External Validation of a Machine Learning Model for Advanced Solid Tumors JAMA Network Open |
Use of Virus Genotypes in Diagnostic Prediction Models for Cervical Cancer in High-Risk HPV JAMA Network Open |
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Neurology
Oncology
Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times JAMA Neurology |
Using Race and Ethnicity in Lung Cancer Prediction Models JAMA Network Open |
Three-Dimensional Structural Phenotype of the Optic Nerve Head as a Function of Glaucoma Severity JAMA Ophthalmology |
Balancing Statistical Precision With Societal Goals to Reduce Health Disparities JAMA Network Open |
Deep Learning Models to Classify and Monitor Scoliosis Using a Single Smartphone Photograph JAMA Network Open |
Trial: AI-Supported Mammography Screening Is Safe, Time-Saving JAMA |
The New Era of Automated Electroencephalogram Interpretation JAMA Neurology |
Use of Artificial Intelligence Chatbots for Cancer Treatment Information JAMA Oncology |
Automated Interpretation of Clinical Electroencephalograms Using Artificial Intelligence JAMA Neurology |
Artificial Intelligence—From Starting Pilots to Scalable Privilege JAMA Oncology |
Studying Healthy Psychosislike Experiences to Improve Illness Prediction JAMA Psychiatry |
Assessment of AI Chatbot Responses to Top Searched Queries About Cancer JAMA Oncology |
Evaluation of Risk of Bias in Neuroimaging-Based AI Models for Psychiatric Diagnosis JAMA Network Open |
Multilevel Model to Identify Patients at Risk for Delay in Starting Cancer Treatment JAMA Network Open |
Deep Learning for Sarcopenia Analysis in Head and Neck Cancer JAMA Network Open |
Accuracy of Stroke Risk Prediction Models by Race, Sex, and Age JAMA |
Use of Virus Genotypes in Diagnostic Prediction Models for Cervical Cancer in High-Risk HPV JAMA Network Open |
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Ophthalmology
Three-Dimensional Structural Phenotype of the Optic Nerve Head as a Function of Glaucoma Severity JAMA Ophthalmology |
Chatbots, Artificial Intelligence, and the Future of Scientific Reporting JAMA Ophthalmology |
Accuracy of Vitreoretinal Disease Information From AI Chat-Based Program JAMA Ophthalmology |
Comparison of Ophthalmologist and AI Chatbot Responses to Online Patient Eye Care Questions JAMA Network Open |
Performance of an Upgraded AI Chatbot for Ophthalmic Knowledge Assessment JAMA Ophthalmology |
Exploring the Test-Taking Capabilities of Chatbots JAMA Ophthalmology |
Artificial Intelligence for Visual Acuity—Gaps From Algorithm to Actualization JAMA Ophthalmology |
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Otolaryngology
Deep Learning for Sarcopenia Analysis in Head and Neck Cancer JAMA Network Open |
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
A Deep Learning Approach to Predict Conductive Hearing Loss in Patients With Otitis Media With Effusion JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Use of Deep Learning to Analyze Social Media Discussions About the HPV Vaccine JAMA Network Open |
Machine Learning Model for Survival Risk Stratification in Advanced Oral Cancer JAMA Network Open |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
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Ophthalmology
Otolaryngology
Deep Learning for Sarcopenia Analysis in Head and Neck Cancer JAMA Network Open |
Three-Dimensional Structural Phenotype of the Optic Nerve Head as a Function of Glaucoma Severity JAMA Ophthalmology |
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
Chatbots, Artificial Intelligence, and the Future of Scientific Reporting JAMA Ophthalmology |
A Deep Learning Approach to Predict Conductive Hearing Loss in Patients With Otitis Media With Effusion JAMA Otolaryngology–Head & Neck Surgery |
Accuracy of Vitreoretinal Disease Information From AI Chat-Based Program JAMA Ophthalmology |
Comparison of Ophthalmologist and AI Chatbot Responses to Online Patient Eye Care Questions JAMA Network Open |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Performance of an Upgraded AI Chatbot for Ophthalmic Knowledge Assessment JAMA Ophthalmology |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Exploring the Test-Taking Capabilities of Chatbots JAMA Ophthalmology |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Artificial Intelligence for Visual Acuity—Gaps From Algorithm to Actualization JAMA Ophthalmology |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
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Pediatrics
Call for Papers on Artificial Intelligence Applied to Pediatric Care JAMA Pediatrics |
Deep Learning Models to Classify and Monitor Scoliosis Using a Single Smartphone Photograph JAMA Network Open |
Communication of COVID-19 Misinformation on Social Media by Physicians in the US JAMA Network Open |
Association of the COVID-19 Pandemic With Pediatric Clinical Trial Publication JAMA Network Open |
Reasons for Discontinuation or Change of Selective Serotonin Reuptake Inhibitors JAMA Network Open |
Deep Learning Model for Retinal Hemorrhage Detection in Young Children JAMA Network Open |
Physician and Biomedical Scientist Harassment During the COVID-19 Pandemic JAMA Network Open |
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Psychiatry
Predicting Suicidal Ideation Among Sexual and Gender Minority Individuals JAMA Network Open |
Reasons for Discontinuation or Change of Selective Serotonin Reuptake Inhibitors JAMA Network Open |
Health Care–Provided Digital Health Technologies for Opioid Use Disorder Treatment JAMA Network Open |
Development of a Machine Learning Prediction Model of PTSD After Military Deployment JAMA Network Open |
Deep Learning Model for Retinal Hemorrhage Detection in Young Children JAMA Network Open |
Deep Learning for Detection and Symptom Severity Assessment of ASD JAMA Network Open |
Studying Healthy Psychosislike Experiences to Improve Illness Prediction JAMA Psychiatry |
Accuracy, User Engagement, and Themes of Eating Disorder Content in Social Media Short Videos JAMA Network Open |
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Pediatrics
Psychiatry
Call for Papers on Artificial Intelligence Applied to Pediatric Care JAMA Pediatrics |
Predicting Suicidal Ideation Among Sexual and Gender Minority Individuals JAMA Network Open |
Deep Learning Models to Classify and Monitor Scoliosis Using a Single Smartphone Photograph JAMA Network Open |
Reasons for Discontinuation or Change of Selective Serotonin Reuptake Inhibitors JAMA Network Open |
Communication of COVID-19 Misinformation on Social Media by Physicians in the US JAMA Network Open |
Health Care–Provided Digital Health Technologies for Opioid Use Disorder Treatment JAMA Network Open |
Deep Learning Model for Retinal Hemorrhage Detection in Young Children JAMA Network Open |
Association of the COVID-19 Pandemic With Pediatric Clinical Trial Publication JAMA Network Open |
Deep Learning for Detection and Symptom Severity Assessment of ASD JAMA Network Open |
Reasons for Discontinuation or Change of Selective Serotonin Reuptake Inhibitors JAMA Network Open |
Studying Healthy Psychosislike Experiences to Improve Illness Prediction JAMA Psychiatry |
Deep Learning Model for Retinal Hemorrhage Detection in Young Children JAMA Network Open |
Accuracy, User Engagement, and Themes of Eating Disorder Content in Social Media Short Videos JAMA Network Open |
Physician and Biomedical Scientist Harassment During the COVID-19 Pandemic JAMA Network Open |
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Surgery
Implications of Using Chatbots for Future Surgical Education JAMA Surgery |
AI in Surgical Curriculum Design and Unintended Outcomes for Technical Competencies JAMA Network Open |
Development of a Machine Learning Tool to Address Racial Disparities in Access to Care JAMA Surgery |
Deep Learning Models to Classify and Monitor Scoliosis Using a Single Smartphone Photograph JAMA Network Open |
Automatic Surgical Skill Assessment Based on Surgical Field Development Using AI JAMA Surgery |
Using Artificial Intelligence to Assess Surgeon Skill JAMA Surgery |
Machine Learning Model to Identify Patients at High Risk for Postoperative Adverse Events JAMA Network Open |
An Informatics Tool to Detect Periprocedural Antibiotic Allergy Adverse Events JAMA Network Open |
Machine Learning–Based Prognostic Model for Patients After Lung Transplantation JAMA Network Open |
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Radiology
Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times JAMA Neurology |
Trial: AI-Supported Mammography Screening Is Safe, Time-Saving JAMA |
Deep Learning Model for Retinal Hemorrhage Detection in Young Children JAMA Network Open |
Use of Deep-Learning Algorithm to Guide Novices in Performing FAST JAMA Network Open |
Evaluation of Risk of Bias in Neuroimaging-Based AI Models for Psychiatric Diagnosis JAMA Network Open |
Artificial Intelligence to Detect Lesions in Digital Breast Tomosynthesis JAMA Network Open |
Chest Radiograph Captions Based on Natural Language Processing vs Completed by Radiologists JAMA Network Open |
Deep Learning–Based Synthetic Bone-Suppressed Model for Pulmonary Nodule Detection JAMA Network Open |
Algorithm to Differentiate Colon Carcinoma From Diverticulitis in Computed Tomography Images JAMA Network Open |
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Surgery
Radiology
Implications of Using Chatbots for Future Surgical Education JAMA Surgery |
Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times JAMA Neurology |
AI in Surgical Curriculum Design and Unintended Outcomes for Technical Competencies JAMA Network Open |
Trial: AI-Supported Mammography Screening Is Safe, Time-Saving JAMA |
Development of a Machine Learning Tool to Address Racial Disparities in Access to Care JAMA Surgery |
Deep Learning Model for Retinal Hemorrhage Detection in Young Children JAMA Network Open |
Automatic Surgical Skill Assessment Based on Surgical Field Development Using AI JAMA Surgery |
Use of Deep-Learning Algorithm to Guide Novices in Performing FAST JAMA Network Open |
Using Artificial Intelligence to Assess Surgeon Skill JAMA Surgery |
Evaluation of Risk of Bias in Neuroimaging-Based AI Models for Psychiatric Diagnosis JAMA Network Open |
Artificial Intelligence to Detect Lesions in Digital Breast Tomosynthesis JAMA Network Open |
Machine Learning Model to Identify Patients at High Risk for Postoperative Adverse Events JAMA Network Open |
Chest Radiograph Captions Based on Natural Language Processing vs Completed by Radiologists JAMA Network Open |
An Informatics Tool to Detect Periprocedural Antibiotic Allergy Adverse Events JAMA Network Open |
Deep Learning–Based Synthetic Bone-Suppressed Model for Pulmonary Nodule Detection JAMA Network Open |
Machine Learning–Based Prognostic Model for Patients After Lung Transplantation JAMA Network Open |
Algorithm to Differentiate Colon Carcinoma From Diverticulitis in Computed Tomography Images JAMA Network Open |
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Original Investigation

APPRAISE-AI Tool to Quantitatively Evaluate AI Studies for Clinical Decision Support

Jethro C. C. Kwong, MD, Adree Khondker, MD et al.

JAMA Network Open |

JAMA Forum

How to Safely Integrate Large Language Models Into Health Care

Scott Gottlieb, MD, Lauren Silvis, JD

JAMA Health Forum |

Original Investigation

Interaction Frequency Before and After COVID-19 Telehealth Implementation

Sarah Nouri, MD, MPH, Courtney R. Lyles, PhD et al.

JAMA Network Open |

Research Letter

Business vs After-Hours Use of an AI Digital Health Platform

Sarah A. Graham, PhD, Sarah K. Pickus, MS et al.

JAMA Network Open |

Original Investigation

Hospital Readmissions by Variation in Engagement in the Health Care Hotspotting Trial

Qiang Yang, PhD, Dawn Wiest, PhD et al.

JAMA Network Open |

Original Investigation

Estimating Sepsis Incidence Using Administrative Data and Clinical Medical Record Review

Lisa Mellhammar, MD, PhD, Erik Wollter, MD et al.

JAMA Network Open |

Research Letter

Quality of Layperson CPR Instructions From Artificial Intelligence Voice Assistants

William Murk, MD, PhD, MPH, MS, Eric Goralnick, MD, MS et al.

JAMA Network Open |

Original Investigation

Effect of Mixed Reality on Emergency Medical Care in Simulated Environment

Jason Lawson, MBBCh, MSc, BSc, Guy Martin, MBBS, PhD et al.

JAMA Network Open |

Original Investigation

Sepsis Prediction Model vs SIRS, qSOFA, and SOFA

Adam R. Schertz, MD, MS, Kristin M. Lenoir, MPH et al.

JAMA Network Open |

Invited Commentary

Alert Timing in Sepsis Prediction Models

Emily A. Balczewski, BA, Patrick G. Lyons, MD, MSc et al.

JAMA Network Open |
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