Explore the latest in cancer genetics, including advances in precision therapy from whole exome sequencing and tumor molecular profiling.
In this essay, a physician describes her experience learning and accepting that she is BRCA2 positive.
This cohort study investigates the association between sickle cell trait and risk of stillbirth in pregnant people.
This case-control study assesses the clinical significance of germline sequencing in children with cancer.
This genetic association study assesses the co-occurrence of melanoma and/or mesothelioma with renal neoplasia, and germline associations with BAP1 and MITF p.E318K alterations in patients who underwent nephrectomy.
This cohort study investigates the association between low levels of ERBB2 expression and progression-free survival among patients with HR+/ERBB2− metastatic breast cancer treated with CDK4/6 inhibitors.
This case series examines the accuracy of a genomic classifier in diagnosis and treatment of patients with indeterminate thyroid nodules.
This Special Communication illustrates the consequences of not adjusting for left truncation and describes an approach to correct for length bias.
This cohort study explores the prognostic association of KRAS variant subtypes with survival and recurrence in patients with intrahepatic cholangiocarcinoma.
This multicenter cohort study of pancreatic cancer family registries in the US and Canada examines age-specific penetrance of pancreatic cancer in individuals with pathogenic variants in the ATM gene.
This randomized clinical trial reports the final overall survival results of ivosidenib (AG-120)—a first-in-class, oral, small-molecule inhibitor of mutant IDH1—vs placebo for patients with unresectable or metastatic cholangiocarcinoma with IDH1 mutation.
This case-control study evaluates the use, sensitivity, and specificity of the cerebrospinal fluid metagenomic next-generation sequencing assay in identifying aneuploidy and other large copy number variations.
This cohort study uses linked registry data to investigate the biological and clinical progression of cancer associated with sociodemographic data and screening vs symptomatic detection in women with nonmetastatic invasive estrogen receptor–positive breast cancers.
This cohort study examines the phenotypic spectrum of Li-Fraumeni syndrome and conducts phenotype-genotype associations across the phenotypic spectrum.
This economic evaluation examines the costs and benefits of cascade testing of siblings of newborns with cancer susceptibility gene variants.
This narrative review describes the diagnosis and treatment of interstitial lung disease associated with the use of antibody-drug conjugates in patients with various types of cancer, including breast, colorectal, gastric, and lung cancer among others.
This nonrandomized clinical trial evaluates the treatment outcomes and safety of mobocertinib treatment in patients with previously treated EGFR exon 20 insertion–positive metastatic non–small cell lung cancer.
This genetic association study examines whether patients who harbor specific clonal hematopoiesis of indeterminate potential variants before rucaparib treatment may be at an increased risk of developing therapy-related myeloid neoplasms.
This cohort study assess gastric cancer risk among patients who received a diagnosis of hereditary lobular breast cancer owing to a germline loss-of-function variant in CDH1 by establishing prevalence of signet ring cell carcinomas among asymptomatic patients.
This Insight reviews adverse health effects of bilateral salpingo-oophorectomy in women prior to the age of natural menopause, and details treatment of such women.
This cohort study assesses the association between the use of prostate magnetic resonance imaging and genomic testing and the initial management of prostate cancer.
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