Explore the latest in hematologic cancer, including primary and secondary coagulopathies, hemophilia and factor deficiencies, and more.
This cohort study examines cause-specific late mortality among individuals who have lived 2 years or more after allogeneic blood or marrow transplantation performed in childhood and whether rates of late mortality have changed over time.
A white woman in her 70s with Alzheimer disease presented with a high hemoglobin level and red blood cell count as well as erythematous macular eruption over the trunk and limbs. What is your diagnosis?
This nonrandomized clinical trial examines the safety, tolerability, immunogenicity, and anti–multiple myeloma activity of the PVX-410 multipeptide vaccine with or without lenalidomide.
A 68-year-old woman with chronic lymphocytic leukemia (CLL) presents with dyspnea on exertion, conjunctival pallor and scleral icterus, and moderate anemia with elevated reticulocytes and LDH and a 3+ anti-IgG direct antiglobulin test (DAT). How do you interpret the results?
This cost-effectiveness analysis uses a decision analytic model to extrapolate trial evidence to estimate the long-term survival and value of tisagenlecleucel for children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia.
This 5-year follow-up of a phase 2 clinical trial assesses long-term durability of minimal residual disease–negative remission and time to disease progression among patients with newly diagnosed multiple myeloma who received triplet-based induction therapy with lenalidomide maintenance therapy.
This case series study describes the frequency of findings of vertical hyperreflective lesions on optical coherence tomography in eyes with vitreoretinal lymphoma.
A 60-year-old man with a history of IgA kappa multiple myeloma was referred for evaluation of an indolent, erythematous papule on his glans penis of 2 weeks’ duration; he denied sexual risk behavior and reported no recent changes in medication. What is your diagnosis?
A middle-aged man presents with painless blurry vision in the left eye and bilateral subretinal fluid in the macula. Late-phase fluorescein angiography reveals multifocal pinpoint areas of hyperfluorescence with mild leakage. What would you do next?
This case report describes a diagnostically challenging electrocardiography finding after apparent chemotherapy infusion reaction.
This cohort study assesses the association of bacteremic sepsis during treatment for acute lymphoblastic leukemia with long-term neurocognitive dysfunction among children.
A 3-year-old girl with B-cell acute lymphoblastic leukemia and no known skin trauma presented with an asymptomatic skin lesion with violaceous to black plaque, a central hemorrhagic bulla, and surrounding hyperemia on the left lower back. What is your diagnosis?
This Clinical Evidence Synopsis summarizes a Cochrane review of randomized trials comparing the effects of bisphosphonate therapy vs placebo or no treatment on mortality, vertebral fractures, nonvertebral fractures, and skeletal-related events among patients with multiple myeloma.
This narrative review discusses the pathophysiology of adult acute lymphoblastic leukemia and recent progress in the development of personalized therapies.
This cohort study assesses whether droplet digital polymerase chain reaction testing could accurately detect MYD88 L265P mutation in the aqueous humor and vitreous fluid of patients with vitreoretinal lymphoma.
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