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    Sarcomas

    Explore the latest in sarcomas, including recent advances in classification, diagnosis, and medical and surgical management.

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    • Effectiveness and Safety of Trabectedin and Radiotherapy for Patients With Myxoid Liposarcoma: A Nonrandomized Clinical Trial
      JAMA Oncology
      Research
      May 1, 2023

      This nonrandomized clinical trial investigates the safety and effectiveness of trabectedin with radiotherapy in patients with myxoid liposarcoma.

      Dermatology Oncology Soft-Tissue Tumors Radiation Oncology
      Full Text | pdf link PDF
    • Pathologic Complete Response and Clinical Outcomes in Patients With Localized Soft Tissue Sarcoma Treated With Neoadjuvant Chemoradiotherapy or Radiotherapy: The NRG/RTOG 9514 and 0630 Nonrandomized Clinical Trials
      JAMA Oncology
      Research
      May 1, 2023

      This ancillary analysis of 2 randomized clinical trials of patients receiving neoadjuvant chemoradiotherapy or preoperative image-guided radiotherapy examines the prognostic significance of pathologic complete response on survival outcomes in patients with soft tissue sarcoma receiving neoadjuvant chemoradiotherapy.

      Oncology Soft-Tissue Tumors Pathology and Laboratory Medicine Radiation Oncology Surgery
      Full Text | pdf link PDF free has multimedia
    • The Significance of a Pathologic Complete Response in Patients With Soft Tissue Sarcoma
      JAMA Oncology
      Opinion
      May 1, 2023
      Oncology Soft-Tissue Tumors Pathology and Laboratory Medicine Dermatology
      Full Text | pdf link PDF free
    • A Case of Multiple Hemorrhagic Friable Nodules
      JAMA Oncology
      Case Report
      March 1, 2023

      A man in his 50s with a history of mycosis fungoides presents with bleeding wounds and nodules on the bilateral hips and forearms. What is your diagnosis?

      Clinical Challenge Lymphomas Skin Lymphomas Dermatology Hematology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Cutaneous Angiosarcoma
      JAMA Dermatology
      Case Report
      March 1, 2023

      This case report describes a large, purpuric plaque involving most of the right face with associated periorbital swelling but without ulceration.

      Dermatology Oncology Soft-Tissue Tumors Images in Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Angiosarcoma Mimicking Rhinophyma
      JAMA Dermatology
      Case Report
      January 1, 2023

      This case report describes a man in his 60s who was referred to the department of dermatology for further evaluation of a lesion on the nose.

      Facial Plastic Surgery Oncology Otolaryngology Soft-Tissue Tumors Images in Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Ocular Kaposi Sarcoma Associated With Systemic Disease and Complete Resolution After Medical Therapy
      JAMA Ophthalmology
      Case Report
      November 17, 2022

      This case report describes a man with untreated HIV infection who presented with Kaposi sarcoma caruncular lesions that resolved completely with medical treatment.

      HIV Infectious Diseases Ophthalmic Images Dermatology Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Activity of Cabazitaxel in Metastatic or Inoperable Locally Advanced Dedifferentiated Liposarcoma: A Phase 2 Study of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG)
      JAMA Oncology
      Research
      October 1, 2022

      This phase 2 nonrandomized clinical trial examines the association of cabazitaxel treatment for patients with advanced dedifferentiated liposarcoma with progression-free survival.

      Dermatology Soft-Tissue Tumors Oncology
      Full Text | pdf link PDF
    • Optimizing Histology-Specific Clinical Trials in Soft-Tissue Sarcoma—Are We There Yet?
      JAMA Oncology
      Opinion
      October 1, 2022
      Oncology Soft-Tissue Tumors Pathology and Laboratory Medicine Dermatology
      Full Text | pdf link PDF
    • Well-Differentiated Hypopharyngeal Liposarcoma–Associated Airway Obstruction
      JAMA Otolaryngology–Head & Neck Surgery
      Case Report
      September 1, 2022

      This case report describes a man in his 70s who presented with a bilobed, cylindrical mucosal mass that had been expelled from his mouth after an episode of nausea and violent vomiting.

      Dermatology Critical Care Medicine Respiratory Failure and Ventilation Oncology Soft-Tissue Tumors
      Full Text | pdf link PDF has multimedia
    • Treatment With Oral Propranolol for Refractory Classic Cutaneous Kaposi Sarcoma
      JAMA Dermatology
      Case Report
      July 1, 2022

      This case report describes a Mediterranean HIV-negative man in his 60s with hypertension, osteoporosis, a history of flaccid paralysis after polio syndrome, and a 4-year history of progressive development of purplish, reddish cutaneous plaques and nodules limited to the lower limbs.

      Oncology Skin Cancer Soft-Tissue Tumors Dermatology
      Full Text | pdf link PDF
    • An Asymptomatic Verrucous Plaque on the Right Temple of an Adolescent Girl
      JAMA Dermatology
      Case Report
      July 1, 2022

      An adolescent girl presented with an asymptomatic slightly reddish verrucous plaque on the right temple; the skin lesion was nail sized when first noticed 1½ years ago, then gradually developed over the previous 8 months. What is your diagnosis?

      Oncology Pediatrics Soft-Tissue Tumors Clinical Challenge Adolescent Medicine
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Sudden-Onset Monocular Blurry Vision in a Young Woman
      JAMA Ophthalmology
      Case Report
      July 1, 2022

      A 32-year-old woman with fever, flulike symptoms, and altered mental status developed sudden-onset blurry vision in her right eye. Following intravenous antibiotics and antivirals, laboratory and imaging results were negative and her mental status improved but blurry vision persisted in the right eye. What would you do next?

      Targeted and Immune Cancer Therapy Oncology Ophthalmology Adverse Drug Events Retinal Disorders
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Orbital Rhabdomyosarcoma With Unusual Histopathology in a Young Adult
      JAMA Ophthalmology
      Case Report
      June 16, 2022

      This case report describes a diagnosis of orbital embryonal rhabdomyosarcoma in a man aged 22 years who presented with eyelid ptosis and diplopia.

      Pathology and Laboratory Medicine Ophthalmic Images External Eye Disease Ophthalmology Orbit
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Efficacy and Safety of TRC105 Plus Pazopanib vs Pazopanib Alone for Treatment of Patients With Advanced Angiosarcoma: A Randomized Clinical Trial
      JAMA Oncology
      Research
      May 1, 2022

      This randomized clinical trial investigates whether carotuximab plus pazopanib improves progression-free survival vs pazopanib alone in adult patients with advanced angiosarcoma.

      Targeted and Immune Cancer Therapy Oncology Soft-Tissue Tumors
      Full Text | pdf link PDF open access
    • Unilateral Leg Swelling in a Young Woman
      JAMA Oncology
      Case Report
      November 1, 2021

      A 33-year-old woman with a history of hereditary bilateral retinoblastoma as an infant presents with 1 week of right lower extremity swelling. What is your diagnosis?

      Pediatric Cancer Intraocular Tumors Oncology Ophthalmology Soft-Tissue Tumors
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Variation in Management of Extremity Soft-Tissue Sarcoma in Younger vs Older Adults
      JAMA Network Open
      Research
      August 20, 2021

      This cohort study investigates variations in treatment management in young adults vs older adults with extremity soft-tissue sarcomas.

      Oncology Surgical Oncology Soft-Tissue Tumors Surgery Orthopedics
      Full Text | pdf link PDF open access
    • Exploration of Immune-Related Gene Expression in Osteosarcoma and Association With Outcomes
      JAMA Network Open
      Research
      August 3, 2021

      This genetic association study examines immune-related gene expression in osteosarcoma samples from The Cancer Genome Atlas project and assesses the association of gene expression profiles with survival outcomes.

      Oncology Orthopedics Genetics and Genomics Cancer Genetics Pediatric Cancer
      Full Text | pdf link PDF open access
    • Stewart-Treves Syndrome
      JAMA Dermatology
      Case Report
      June 1, 2021

      This case report describes diffuse yellow pigmentation and scattered ecchymotic lesions.

      Breast Cancer Dermatology Oncology Women's Health Images in Dermatology
      Full Text | pdf link PDF
    • Lower Back Pain in a Patient With Sarcoma
      JAMA Oncology
      Case Report
      June 1, 2021

      A 39-year-old woman with alveolar rhabdomyosarcoma and bone metastases presents with lower back pain. The treatment regimen recently was changed to gemcitabine hydrochloride and docetaxel, and imaging shows edema in both psoas muscles. What is your diagnosis?

      Radiation Oncology Clinical Challenge Oncology Soft-Tissue Tumors
      Full Text | pdf link PDF | CME & MOC is active quiz
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