Explore the latest in sarcomas, including recent advances in classification, diagnosis, and medical and surgical management.
A 33-year-old woman with a history of hereditary bilateral retinoblastoma as an infant presents with 1 week of right lower extremity swelling. What is your diagnosis?
This cohort study investigates variations in treatment management in young adults vs older adults with extremity soft-tissue sarcomas.
This genetic association study examines immune-related gene expression in osteosarcoma samples from The Cancer Genome Atlas project and assesses the association of gene expression profiles with survival outcomes.
This case report describes diffuse yellow pigmentation and scattered ecchymotic lesions.
A 39-year-old woman with alveolar rhabdomyosarcoma and bone metastases presents with lower back pain. The treatment regimen recently was changed to gemcitabine hydrochloride and docetaxel, and imaging shows edema in both psoas muscles. What is your diagnosis?
A 29-year-old man presented with a 2-month history of rapidly growing, widespread, asymptomatic skin nodules all over his body, without ulceration or scarring. What is your diagnosis?
This cohort study examines the cancer prevalence and survival outcomes among patients with neurofibromatosis type 1 vs the general population.
This cohort study assesses whether lymphopenia at diagnosis is associated with overall survival among patients with localized bone and soft tissue sarcoma.
This case report describes diffusively enlarged, erythematous, and cobblestoned maxillary and mandibular buccal gingivae.
This randomized clinical trial examines the efficacy of gemcitabine and pazopanib compared with pazopanib alone for German patients with soft tissue sarcoma.
This nonrandomized controlled trial reports the oncological outcomes of the deintensification (from 50 Gy to 36 Gy) of a preoperative radiotherapy regimen for adults with myxoid liposarcoma.
This cohort study compares overall survival among patients with nonmetastatic, resectable retroperitoneal sarcoma treated with surgical treatment alone vs surgical treatment and chemotherapy or radiation.
This nonrandomized clinical trial evaluates the use of doxorubicin and pembrolizumab in patients with metastatic/unresectable anthracycline-naive sarcoma.
This cohort study compares the risk of secondary sarcoma among patients treated with combinations of surgery, radiation, and chemotherapy with patients treated with surgery alone and with the general population.
A man in his 60s with a history of allogenic hematopoietic stem cell transplant for acute myelogenous leukemia presents with asymptomatic green-gray nodules and plaques on the chest. What is your diagnosis?
A man in his 80s presented with asymmetric, centrofacial, erythematous-violaceous indurated telangiectatic and ecchymotic plaques over a phymatous background. What is your diagnosis?
This next-generation exome sequencing study investigates the frequency of pathogenic or likely pathogenic germline genetic variants in known cancer-susceptibility genes among patients with osteosarcoma.
This randomized trial compares the effect of doxorubicin plus olaratumab vs doxorubicin plus placebo on overall survival in patients with advanced/metastatic soft tissue sarcoma and leiomyosarcoma.
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