Explore the latest in sarcomas, including recent advances in classification, diagnosis, and medical and surgical management.
This nonrandomized controlled trial reports the oncological outcomes of the deintensification (from 50 Gy to 36 Gy) of a preoperative radiotherapy regimen for adults with myxoid liposarcoma.
This cohort study compares overall survival among patients with nonmetastatic, resectable retroperitoneal sarcoma treated with surgical treatment alone vs surgical treatment and chemotherapy or radiation.
This nonrandomized clinical trial evaluates the use of doxorubicin and pembrolizumab in patients with metastatic/unresectable anthracycline-naive sarcoma.
This cohort study compares the risk of secondary sarcoma among patients treated with combinations of surgery, radiation, and chemotherapy with patients treated with surgery alone and with the general population.
A man in his 60s with a history of allogenic hematopoietic stem cell transplant for acute myelogenous leukemia presents with asymptomatic green-gray nodules and plaques on the chest. What is your diagnosis?
A man in his 80s presented with asymmetric, centrofacial, erythematous-violaceous indurated telangiectatic and ecchymotic plaques over a phymatous background. What is your diagnosis?
This next-generation exome sequencing study investigates the frequency of pathogenic or likely pathogenic germline genetic variants in known cancer-susceptibility genes among patients with osteosarcoma.
This randomized trial compares the effect of doxorubicin plus olaratumab vs doxorubicin plus placebo on overall survival in patients with advanced/metastatic soft tissue sarcoma and leiomyosarcoma.
A middle-aged woman presented with a tender, pruritic, 4-cm erythematous patch on the forehead that enlarged over the course of 6 weeks. What is your diagnosis?
This nonrandomized phase 1/2 clinical trial evaluates the use of trabectedin in combination with low-dose radiotherapy for treating metastatic soft-tissue sarcomas in adult patients.
This case report presents the response to experimental drug gilteritinib hemifumarate in a patient with ophthalmological complications of relapsed acute myeloid leukemia with FMS-like tyrosine kinase 3 (FLT3) gene mutation.
This phase 2 clinical trial examines whether talimogene laherparepvec in combination with pembrolizumab is associated with increased tumor-infiltrating lymphocyte infiltration and programmed death-ligand 1 expression, and thus with increased antitumor activity in patients with locally advanced or metastatic sarcoma.
In this narrative medicine essay, an internal medicine intern with metastatic osteosarcoma tells what it is like to be a patient facing a grave disease and explains that she needs commitment, empathy, and presence from her physicians.
A young man with a history of adenosine deaminase–deficient severe combined immunodeficiency presented with atrophic papules and plaques on the trunk and extremities. What is your diagnosis?
This survey study collaborates with patients with dermatofibrosarcoma protuberans through social media to evaluate sources of diagnostic delay, risk of recurrence, and flat presentation of dermatofibrosarcoma protuberans.
A 71-year-old healthy woman has an enlarging, immobile, painless mass in her right gluteal area, with no neurovascular deficits; computed tomography reveals an 11-cm heterogeneous lipomatous tumor involving the right gluteal musculature. What is the diagnosis and what would you do next?
An African American man with a history of bipolar disorder presented to the emergency department with an enlarging right-sided tongue mass that had caused mild discomfort and halitosis over the course of 1 week. What is your diagnosis?
This case study describes a man in his 60s who presented with a 2-year history of gradual-onset right facial weakness leading to paralysis.
This case report describes orbital apex syndrome in a young man with histiocytic sarcoma.
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