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    Soft-Tissue Tumors

    Explore the latest in soft-tissue tumors, including recent advances in classification, diagnosis, and medical and surgical management.

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    • Violaceous Nodules on the Right Leg and Foot
      JAMA
      Case Report
      November 20, 2023

      An patient with a history of bullous pemphigoid treated with oral prednisolone presented with multiple round, dark brown to violaceous-colored firm nodules on the right leg and 2 nodular masses with hemorrhagic crusts on the right foot. Complete blood cell count and creatinine and liver function test results were normal, and results of HIV antibody testing were negative. What is the diagnosis and what would you do next?

      Pathology and Laboratory Medicine Clinical Challenge Infectious Diseases Dermatology Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Guideline-Based Follow-Up Outcomes in Patients With Gastrointestinal Stromal Tumor With Low Risk of Recurrence: A Report From the Italian Sarcoma Group
      JAMA Network Open
      Research
      November 6, 2023

      This cohort study examines the outcomes observed after guideline-based 5- and 10-year follow-up in patients with gastrointestinal stromal tumor at low risk of recurrence following surgery.

      Oncology Surgery Surgical Oncology Gastroenterology Gastrointestinal Cancer
      Full Text | pdf link PDF open access
    • Toll-Like Receptor 4 Agonist Injection With Concurrent Radiotherapy in Patients With Metastatic Soft Tissue Sarcoma: A Phase 1 Nonrandomized Controlled Trial
      JAMA Oncology
      Research
      October 12, 2023

      This nonrandomized controlled trial of patients with advanced soft tissue sarcoma analyzed the immunomodulatory effects of intratumoral glycopyranosyl lipid A in stable-emulsion formulation with concurrent radiotherapy.

      Targeted and Immune Cancer Therapy Oncology Radiation Oncology Sarcomas
      Full Text | pdf link PDF open access
    • Novel PAX3::INO80D Fusion in Biphenotypic Sinonasal Sarcoma in an Adult
      JAMA Otolaryngology–Head & Neck Surgery
      Case Report
      September 1, 2023

      This case report describes a novel gene fusion of PAX3::INO80D in a biphenotypic sinonasal carcinoma in a woman in her 40s.

      Head and Neck Cancer Oncology Otolaryngology Cancer Genetics Sarcomas
      Full Text | pdf link PDF
    • Narrow Angle Associated With an Iris Cavernous Hemangioma
      JAMA Ophthalmology
      Case Report
      August 17, 2023

      This case report discusses a diagnosis of iris cavernous hemangioma in a woman aged 63 years who presented with recurrent pain, redness, and hazy vision in her left eye.

      Oncology Ophthalmic Images Ophthalmology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • The Association Between Meningioma and Breast Cancer: A Systematic Review and Meta-analysis
      JAMA Network Open
      Research
      June 16, 2023

      This systematic review and meta-analysis describes the literature on the associations between meningioma and breast cancer and analyzes the available data.

      Oncology Surgery Breast Cancer Neurosurgery Women's Health
      Full Text | pdf link PDF open access
    • From a High School Student to an Otolaryngologist—19 Years With a Jugular Foramen Meningioma
      JAMA Otolaryngology–Head & Neck Surgery
      Opinion
      June 1, 2023

      In this essay, an otolaryngologist reflects on the circular journey from patient to physician to patient again over 19 years living with a left jugular foramen meningioma.

      Neuro-oncology Oncology Otolaryngology Skull Base Adolescent Medicine
      Full Text | pdf link PDF
    • CLOVES Syndrome
      JAMA Dermatology
      Case Report
      June 1, 2023

      This case report describes an infant with large capillary malformations on the trunk, edematous left axilla and upper arm with loose skin and subcutaneous soft tissue tumors, and bilateral overgrowth of the feet with syndactyly of toes.

      Dermatology Nevi Images in Dermatology Cutaneous Vascular Malformations Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Effectiveness and Safety of Trabectedin and Radiotherapy for Patients With Myxoid Liposarcoma: A Nonrandomized Clinical Trial
      JAMA Oncology
      Research
      May 1, 2023

      This nonrandomized clinical trial investigates the safety and effectiveness of trabectedin with radiotherapy in patients with myxoid liposarcoma.

      Dermatology Oncology Radiation Oncology Sarcomas
      Full Text | pdf link PDF
    • Pathologic Complete Response and Clinical Outcomes in Patients With Localized Soft Tissue Sarcoma Treated With Neoadjuvant Chemoradiotherapy or Radiotherapy: The NRG/RTOG 9514 and 0630 Nonrandomized Clinical Trials
      JAMA Oncology
      Research
      May 1, 2023

      This ancillary analysis of 2 randomized clinical trials of patients receiving neoadjuvant chemoradiotherapy or preoperative image-guided radiotherapy examines the prognostic significance of pathologic complete response on survival outcomes in patients with soft tissue sarcoma receiving neoadjuvant chemoradiotherapy.

      Oncology Pathology and Laboratory Medicine Radiation Oncology Surgery Surgical Oncology
      Full Text | pdf link PDF has multimedia
    • The Significance of a Pathologic Complete Response in Patients With Soft Tissue Sarcoma
      JAMA Oncology
      Opinion
      May 1, 2023
      Oncology Pathology and Laboratory Medicine Dermatology Sarcomas
      Full Text | pdf link PDF
    • Slow-Growing Pediatric Neck Mass
      JAMA Otolaryngology–Head & Neck Surgery
      Case Report
      May 1, 2023

      An 11-year-old girl with no significant medical history was referred to the pediatric otolaryngology department for a painless, left-sided neck mass that had been slowly enlarging for 8 months. What is your diagnosis?

      Oncology Pediatrics Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Cutaneous Angiosarcoma
      JAMA Dermatology
      Case Report
      March 1, 2023

      This case report describes a large, purpuric plaque involving most of the right face with associated periorbital swelling but without ulceration.

      Dermatology Oncology Sarcomas Images in Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Persistent Green-Blue Plaque in a Healthy Woman
      JAMA Dermatology
      Case Report
      March 1, 2023

      A woman in her 30s presents with a bruise on her hand with a blue-green plaque that appeared after a twisting injury to the affected hand. What is your diagnosis?

      Dermatology Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • A Case of Multiple Hemorrhagic Friable Nodules
      JAMA Oncology
      Case Report
      March 1, 2023

      A man in his 50s with a history of mycosis fungoides presents with bleeding wounds and nodules on the bilateral hips and forearms. What is your diagnosis?

      Clinical Challenge Lymphomas Skin Lymphomas Dermatology Hematology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Large Bilateral Compressible Neck Mass in 55-Year-Old Man
      JAMA Otolaryngology–Head & Neck Surgery
      Case Report
      February 1, 2023

      A 55-year-old man with a medical history significant for hypertension, coronary artery disease, and obstructive sleep apnea presents with an enlarging neck mass of more than 2 years’ duration. What is your diagnosis?

      Oncology Otolaryngology Head and Neck Surgery Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Acute Unilateral Proptosis After Blunt Orbital Trauma in an Adolescent Patient
      JAMA Ophthalmology
      Case Report
      January 1, 2023

      A male patient aged 16 years with a recent history of blunt trauma to the periorbita presented with blurred vision, pain, and proptosis of the right eye. MRI imaging revealed an intraconal mass. What would you do next?

      Emergency Medicine Intraocular Tumors Oncology Ophthalmology Orbit
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Angiosarcoma Mimicking Rhinophyma
      JAMA Dermatology
      Case Report
      January 1, 2023

      This case report describes a man in his 60s who was referred to the department of dermatology for further evaluation of a lesion on the nose.

      Facial Plastic Surgery Oncology Otolaryngology Images in Dermatology Sarcomas
      Full Text | pdf link PDF
    • Pooled Analysis of Meningioma Risk Following Treatment for Childhood Cancer
      JAMA Oncology
      Research
      December 1, 2022

      This case-control study evaluates meningioma risk following radiotherapy and chemotherapy and identifies possible factors associated with modifying radiation-associated risk in survivors of childhood cancer.

      Oncology Cancer Epidemiology Cancer Survivorship Neuro-oncology Neurology
      Full Text | pdf link PDF open access
    • Ocular Kaposi Sarcoma Associated With Systemic Disease and Complete Resolution After Medical Therapy
      JAMA Ophthalmology
      Case Report
      November 17, 2022

      This case report describes a man with untreated HIV infection who presented with Kaposi sarcoma caruncular lesions that resolved completely with medical treatment.

      HIV Infectious Diseases Ophthalmic Images Dermatology Oncology
      Full Text | pdf link PDF
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