Explore JAMA's 2015 series featuring common-sense descriptions of the frontiers of biomedical research by the world's most eminent scientists.
This Viewpoint describes the processes by which aging of cells contributes to age-related decline, chronic disease, and multimorbidity, and describes current animal research and clinical trials investigating the effects of senolytic drugs and vaccines that target senescent cell antiapoptotic pathways and remove senescent cells.
This viewpoint discusses increased life expectancy and the initiatives to address the risks and unintended consequences of living longer.
This Viewpoint discusses targeting fundamental biological aging processes through nutritional, genetic, and pharmacologic interventions to delay or prevent the onset or progression of multiple chronic diseases and debilities typically observed in older humans to enhance and extend both health and longevity.
This Viewpoint describes the theory-driven and data-driven branches of computational psychiatry and how it might advance clinical improvements for patients.
This Viewpoint discusses the significance of investing billions of dollars in genomic sequencing and the implications of finding a hereditary mutation in patients with metastatic cancer using next-generation sequencing.
This narrative review summarizes the current state of genomic testing for somatic mutations in breast cancer and considers approaches for more effective implementation.
This Viewpoint highlights recent findings in the treatment of central nervous system tumors.
This Viewpoint discusses 2 next-generation approaches to diagnosis and therapy that are either already clinically relevant or likely to be tested in central nervous system neurotropic viral infections in the near future.
This Viewpoint discusses the potential to create a national health data system with detailed patient- and hospital-level data sets that could help identify gaps in care; scientifically test regional, state, and federal policies in an iterative manner; and improve health care and outcomes nationwide.
This review uses the example of hereditary ataxias to assess the contribution of next-generation sequencing to identification of the genetic basis of neurogenetic syndromes.
This Viewpoint compares the advantages and disadvantages of x-ray, proton, and heavy-ion therapy in cancer treatment, and the future of heavy-ion therapy in the United States.
This review examines methods for the identification, prevention, and treatment of cardiovascular complications related to cancer therapy.
This perspective discusses the advent of medical imaging as a data source for precision management of patients with cancer through integration of automated imaging phenotype and cancer genotype.
This Viewpoint discusses the benefit of treating patients with heart failure with sacubitril/valsartan compared with angiotensin-converting enzyme inhibitors.
This review discusses barriers to the clinical implementation of stem cell therapy in patients with cardiovascular disease as well as potential strategies to overcome them.
In this Special Communication, FDA Commissioner Robert Califf proposes ways to scale up the national cardiovascular research enterprise through use of interoperable clinical and trial data registries and broadly distributed learning networks.
This report describes the Delphi process used by the Patient-Reported Outcomes in Surgery Conference to develop a consensus-based research agenda focusing on patient-reported outcomes.
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