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    Lymphomas

    Explore the latest in lymphomas, including recent advances in diagnosis and management of Hodgkin and non-Hodgkin lymphomas.

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    • Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review
      JAMA
      Review
      March 21, 2023

      This narrative review discusses the pathophysiology, clinical presentation, and diagnosis, and staging of chronic lymphocytic leukemia and summarizes current treatments.

      Geriatrics Hematology Oncology Hematologic Cancer Leukemias
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
    • Clinical Trials Portfolio and Regulatory History of Idelalisib in Indolent Non-Hodgkin Lymphoma: A Systematic Review and Meta-analysis
      JAMA Internal Medicine
      Research
      March 20, 2023

      This systematic review with meta-analysis examines the regulatory oversight of the accelerated approval pathway and evidence generation for idelalisib during premarketing, postmarketing, and premarketing withdrawal periods.

      Hematology Targeted and Immune Cancer Therapy Oncology Health Care Safety Hematologic Cancer
      Full Text | pdf link PDF open access
    • Pembrolizumab Added to Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Relapsed or Refractory Classic Hodgkin Lymphoma: A Multi-institutional Phase 2 Investigator-Initiated Nonrandomized Clinical Trial
      JAMA Oncology
      Research
      March 16, 2023

      This nonrandomized clinical trial investigates the addition of pembrolizumab to ifosfamide, carboplatin, and etoposide chemotherapy and evaluates the response rate of patients with relapsed or refractory Hodgkin lymphoma.

      Oncology Targeted and Immune Cancer Therapy Hematology Hematologic Cancer
      Full Text | pdf link PDF
    • A Case of Multiple Hemorrhagic Friable Nodules
      JAMA Oncology
      Case Report
      March 1, 2023

      A man in his 50s with a history of mycosis fungoides presents with bleeding wounds and nodules on the bilateral hips and forearms. What is your diagnosis?

      Clinical Challenge Skin Lymphomas Dermatology Hematology Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Heart Failure in Patients With Cancer Treated With Anthracyclines—Revisiting the Foundation of Cardio-Oncology
      JAMA Network Open
      Opinion
      February 3, 2023
      Cardiology Breast Cancer Hematology Oncology Hematologic Cancer
      Full Text | pdf link PDF open access
    • Association of Anthracycline With Heart Failure in Patients Treated for Breast Cancer or Lymphoma, 1985-2010
      JAMA Network Open
      Research
      February 3, 2023

      This case-control study compares the long-term incidence of congestive heart failure in patients treated for breast cancer or lymphoma with anthracycline therapy compared with healthy controls from the same community.

      Cardiology Clinical Pharmacy and Pharmacology Breast Cancer Cancer Survivorship Adverse Drug Events
      Full Text | pdf link PDF open access
    • Association of Radiation and Procarbazine Dose With Risk of Colorectal Cancer Among Survivors of Hodgkin Lymphoma
      JAMA Oncology
      Research
      February 2, 2023

      This nested case-control study of 5-year Hodgkin lymphoma survivors explores dose-response associations of radiation therapy and procarbazine with colorectal cancer.

      Colorectal Cancer Gastroenterology Gastrointestinal Cancer Oncology Cancer Survivorship
      Full Text | pdf link PDF open access
    • Characteristics and Outcomes for Hospitalized Patients With Cutaneous T-Cell Lymphoma
      JAMA Dermatology
      Research
      February 1, 2023

      This cohort study characterizes the clinical characteristics, course of hospitalization, and mortality outcomes of an inpatient cohort with cutaneous T-cell lymphoma.

      Dermatology Hematology Oncology Hematologic Cancer Skin Lymphomas
      Full Text | pdf link PDF
    • A Case of Unilateral Intraocular Pressure Elevation in a Patient With Glaucoma
      JAMA Ophthalmology
      Case Report
      January 1, 2023

      A 52-year-old man with a history of severe primary open-angle glaucoma in both eyes presented with an intraocular pressure above target in the left eye. A 24-2 Humphrey visual field showed new glaucoma progression. What would you do next?

      Glaucoma Hematology Oncology Ophthalmology Radiation Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Cost-effectiveness of Axicabtagene Ciloleucel and Tisagenlecleucel as Second-line or Later Therapy in Relapsed or Refractory Diffuse Large B-Cell Lymphoma
      JAMA Network Open
      Research
      December 15, 2022

      This economic evaluation assesses the cost-effectiveness of axicabtagene ciloleucel and tisagenlecleucel vs standard care as second-line or later therapy for relapsed or refractory diffuse large B-cell lymphoma.

      Oncology Targeted and Immune Cancer Therapy Pharmacoeconomics Health Policy Health Care Economics, Insurance, Payment
      Full Text | pdf link PDF open access
    • Generalized Cutaneous Nodules on the Trunk and Extremities
      JAMA Oncology
      Case Report
      December 1, 2022

      A 61-year-old man presented with rapidly growing and itchy cutaneous nodules all over his body and prominent lymphadenopathies. What is your diagnosis?

      Dermatology Oncology Skin Lymphomas Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Risk of Anaplastic Large Cell Lymphoma Following Postmastectomy Implant Reconstruction in Women With Breast Cancer and Ductal Carcinoma in Situ
      JAMA Network Open
      Research
      November 22, 2022

      This cohort study examines the risk of anaplastic large cell lymphoma (ALCL) following postmastectomy implant reconstruction among US women with breast cancer and ductal carcinoma in situ (DCIS).

      Hematology Medical Devices and Equipment Oncology Surgery Surgical Oncology
      Full Text | pdf link PDF open access
    • Clinical Presentation and Outcome Differences Between Black Patients and Patients of Other Races and Ethnicities With Mycosis Fungoides and Sézary Syndrome
      JAMA Dermatology
      Research
      November 1, 2022

      This cohort study assesses racial differences in presentation and outcome and identifies drivers for racial disparities among patients with mycosis fungoides and Sézary syndrome.

      Dermatology Hematology Oncology Hematologic Cancer Skin Lymphomas
      Full Text | pdf link PDF
    • Incidence Trends of Primary Cutaneous T-Cell Lymphoma in the US From 2000 to 2018: A SEER Population Data Analysis
      JAMA Oncology
      Research
      November 1, 2022

      Using SEER database data, this cohort study analyzed cutaneous T-cell lymphoma incidence by tumor subtype, sex, age, race and ethnicity, socioeconomic status, and geography.

      Dermatology Hematology Oncology Hematologic Cancer Skin Lymphomas
      Full Text | pdf link PDF open access
    • Assessment of Pretreatment and Posttreatment Evolution of Neurofilament Light Chain Levels in Patients Who Develop Immune Effector Cell–Associated Neurotoxicity Syndrome
      JAMA Oncology
      Research
      November 1, 2022

      This cross-sectional study quantifies serial neurofilament light chain levels in patients undergoing cellular therapy.

      Hematology Oncology Hematologic Cancer Adverse Drug Events Neurology
      Full Text | pdf link PDF open access
    • Combined Ophthalmic Artery and Central Retinal Vein Occlusion Secondary to Advanced Mantle Cell Lymphoma
      JAMA Ophthalmology
      Case Report
      October 20, 2022

      This case report describes a diagnosis of ophthalmic artery and central retinal vein occlusion in a female patient with a history of end-stage mantle cell lymphoma.

      Ophthalmology Retinal Disorders Ophthalmic Images Hematologic Cancer Hematology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • New Breast Implant Safety Concerns
      JAMA
      News
      October 18, 2022
      Oncology Soft-Tissue Tumors Women's Health Surgery Surgical Oncology
      Full Text | pdf link PDF
    • Clinical and Pathological Characteristics and Outcomes Among Patients With Subcutaneous Panniculitis-like T-Cell Lymphoma and Related Adipotropic Lymphoproliferative Disorders
      JAMA Dermatology
      Research
      October 1, 2022

      This case series evaluates a cohort of patients with subcutaneous panniculitis-like T-cell lymphoma and related conditions to characterize their clinical and pathological presentation, management, disease course, and outcome.

      Skin Lymphomas Pathology and Laboratory Medicine Oncology Dermatology Stem Cell Transplantation
      Full Text | pdf link PDF
    • Incidence of Anaplastic Large-Cell Lymphoma of the Breast in the US, 2000 to 2018
      JAMA Oncology
      Research
      September 1, 2022

      This cohort study of data from the Surveillance, Epidemiology, and End Results 18 database examines the incidence of anaplastic large-cell lymphoma of the breast in the US from 2000 to 2018.

      Breast Cancer Oncology Surgery Surgical Oncology Soft-Tissue Tumors
      Full Text | pdf link PDF
    • Efficacy and Safety of Topical Hypericin Photodynamic Therapy for Early-Stage Cutaneous T-Cell Lymphoma (Mycosis Fungoides): The FLASH Phase 3 Randomized Clinical Trial
      JAMA Dermatology
      Research
      September 1, 2022

      This randomized clinical trial of hypericin ointment, 0.25%, for patients with early-stage mycosis fungoides−cutaneous T-cell lymphoma examines lesion response rates and adverse events to determine the efficacy and safety of this novel photodynamic therapy.

      Hematology Oncology Hematologic Cancer Skin Lymphomas Dermatology
      Full Text | pdf link PDF
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