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    Leukemias

    Explore the latest in leukemias, including recent advances in management of acute and chronic lymphocytic and myeloid leukemias.

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    • A Man With Kaleidoscope Vision
      JAMA Ophthalmology
      Case Report
      June 1, 2023

      A 63-year-old man with a history of stage 3 cutaneous melanoma of the scalp and chronic lymphocytic leukemia presents with kaleidoscope vision. What would you do next?

      Dermatology Clinical Pharmacy and Pharmacology Hematology Melanoma Skin Cancer
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Clinical Characteristics and Outcomes of Cancer Cases Among Syrian Refugees From Southern Turkey
      JAMA Network Open
      Research
      May 23, 2023

      This cross-sectional study examines the incidence and survival rates for Syrian adults and children with cancer residing in Turkey as refugees.

      Oncology Pediatric Cancer Global Health Violence Global Violence
      Full Text | pdf link PDF open access
    • The Snowstorm
      JAMA
      Opinion
      May 23, 2023

      In this narrative medicine essay, a family physician takes a moment-by-moment, one-step-at-a-time approach to move from her couch to recovery from treatment for lymphoblastic leukemia to finally reaching the cross-country ski trails.

      Humanities Hematology Oncology Hematologic Cancer A Piece of My Mind
      Full Text | pdf link PDF
    • Eruptive Acral Nevi Secondary to Treatment With Chemotherapy
      JAMA Dermatology
      Case Report
      May 17, 2023

      This case report describes an eruption of junctional nevi on the dorsum of both feet.

      Pediatric Cancer Hematology Oncology Pediatrics Hematologic Cancer
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Bilateral Hypopyon in a Young Woman
      JAMA Ophthalmology
      Case Report
      April 20, 2023

      A 28-year-old woman presented to the emergency department with a 5-day history of bilateral blurry vision, eye redness, discharge, photophobia, and pain. There were more than 20 cells per high-power field of 1 mm × 1 mm beam, with fibrin bilaterally and 2.5-mm hypopyon in the right eye and 2.7-mm hypopyon in the left eye. What would you do next?

      Hematology Oncology Ophthalmology Hematologic Cancer Intraocular Inflammation
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Revumenib Appears Safe in Leukemia Trial, Yields Remission in Some
      JAMA
      News
      April 18, 2023
      Hematology Targeted and Immune Cancer Therapy Oncology Hematologic Cancer
      Full Text | pdf link PDF free
    • Trends in Medicare Spending on Oral Drugs for Chronic Lymphocytic Leukemia From 2014 to 2020
      JAMA Network Open
      Research
      April 7, 2023

      This cross-sectional study analyzes trends in Medicare Part D use and spending on oral-targeted drugs for chronic lymphocytic leukemia from 2014 to 2020.

      Health Policy Hematology Oncology Hematologic Cancer Health Care Economics, Insurance, Payment
      Full Text | pdf link PDF open access
    • Allogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients With Intermediate-Risk Acute Myeloid Leukemia: A Randomized Clinical Trial
      JAMA Oncology
      Research
      April 1, 2023

      This randomized clinical trial of adults with intermediate-risk acute myeloid leukemia explores the optimal therapy for these patients after complete remission.

      Stem Cell Transplantation Hematology Hematologic Cancer Oncology
      Full Text | pdf link PDF
    • Prognostic Value of Cutaneous Disease Severity Estimates on Survival Outcomes in Patients With Chronic Graft-vs-Host Disease
      JAMA Dermatology
      Research
      April 1, 2023

      This cohort study assesses the prognostic value of body surface area and National Institutes of Health Skin Score on survival outcomes stratified by erythema and sclerosis subtypes of chronic graft-vs-host disease.

      Stem Cell Transplantation Dermatology Hematology Oncology Hematologic Cancer
      Full Text | pdf link PDF
    • Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review
      JAMA
      Review
      March 21, 2023

      This narrative review discusses the pathophysiology, clinical presentation, and diagnosis, and staging of chronic lymphocytic leukemia and summarizes current treatments.

      Geriatrics Hematology Oncology Hematologic Cancer Lymphomas
      Full Text | pdf link PDF | CME & MOC free is active quiz has multimedia
    • DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant
      JAMA
      Research
      March 7, 2023

      In this observational study, targeted deep DNA sequencing was performed to test the hypothesis that detection of specific residual AML-associated variants in the blood of patients in first remission prior to allogeneic hematopoietic cell transplant would be associated with higher rates of relapse and mortality after transplant

      Cancer Genetics Hematology Oncology Genetics and Genomics Hematologic Cancer
      Full Text | pdf link PDF
    • Evaluation of Maternal Infection During Pregnancy and Childhood Leukemia Among Offspring in Denmark
      JAMA Network Open
      Research
      February 20, 2023

      This cohort study used national registry data for all children born in Denmark between 1978 to 2015 to examine the association of maternal infection during pregnancy with childhood leukemia among offspring.

      Pediatrics Antenatal Exposures and Child Outcomes Pediatric Cancer Infectious Diseases Oncology
      Full Text | pdf link PDF open access
    • Evaluation of the Association Between Congenital Cytomegalovirus Infection and Pediatric Acute Lymphoblastic Leukemia
      JAMA Network Open
      Research
      January 9, 2023

      This case-control study evaluates the association between congenital cytomegalovirus infection and pediatric acute lymphoblasic leukemia.

      Hematology Neonatology Antenatal Exposures and Child Outcomes Obstetrics Obstetrics and Gynecology
      Full Text | pdf link PDF open access
    • Does Cytomegalovirus Play a Role in Pediatric Lymphoblastic Leukemogenesis?
      JAMA Network Open
      Opinion
      January 9, 2023
      Hematology Infectious Diseases Neonatology Oncology Hematologic Cancer
      Full Text | pdf link PDF open access
    • Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia
      JAMA Network Open
      Research
      December 29, 2022

      This genetic association study replicated previously identified genetic factors and assessed novel genetic factors associated with hepatic toxic effects during treatment in pediatric patients with acute lymphoblastic leukemia (ALL).

      Oncology Pharmacogenetics Cancer Genetics Clinical Pharmacy and Pharmacology Genetics and Genomics
      Full Text | pdf link PDF open access
    • “Off-the-Shelf” CAR T-Cell Therapy Tested in Pediatric B-Cell Leukemia
      JAMA
      News
      December 13, 2022
      Pediatric Cancer Targeted and Immune Cancer Therapy Oncology Hematology Hematologic Cancer
      Full Text | pdf link PDF
    • Mortality Among Pediatric Patients With Acute Lymphoblastic Leukemia in Sweden From 1988 to 2017
      JAMA Network Open
      Research
      November 28, 2022

      This cohort study compares mortality among Swedish pediatric patients diagnosed with acute lymphoblastic leukemia with that in the general population of Sweden from 1988 to 2017.

      Hematology Oncology Pediatric Cancer Hematologic Cancer Pediatrics
      Full Text | pdf link PDF open access
    • A Place Where I Belong
      JAMA
      Opinion
      September 13, 2022

      In this narrative medicine essay, a neurologist diagnosed with acute leukemia describes how her medical experience changed the warm feelings she had while working in the hospital setting over her 35-year career.

      Humanities Hematology Oncology Hematologic Cancer A Piece of My Mind
      Full Text | pdf link PDF
    • Treatment of Adults With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia—From Intensive Chemotherapy Combinations to Chemotherapy-Free Regimens: A Review
      JAMA Oncology
      Review
      September 1, 2022

      This Review reports current evidence for frontline therapies of Philadelphia chromosome–positive acute lymphoblastic leukemia, the major principles that guide therapy, and the progress with chemotherapy-free regimens.

      Stem Cell Transplantation Targeted and Immune Cancer Therapy Oncology Hematologic Cancer Hematology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Association of Leukocyte Adhesion and Rolling in Skin With Patient Outcomes After Hematopoietic Cell Transplantation Using Noninvasive Reflectance Confocal Videomicroscopy
      JAMA Dermatology
      Research
      June 1, 2022

      This cohort study identifies a quantitative characteristic of leukocyte-endothelial interactions after hematopoietic cell transplantation and tests its associations with patient outcomes.

      Hematology Oncology Hematologic Cancer Lymphomas Pathology and Laboratory Medicine
      Full Text | pdf link PDF free has multimedia
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