Explore the latest in leukemias, including recent advances in management of acute and chronic lymphocytic and myeloid leukemias.
This cohort study examines cause-specific late mortality among individuals who have lived 2 years or more after allogeneic blood or marrow transplantation performed in childhood and whether rates of late mortality have changed over time.
A 68-year-old woman with chronic lymphocytic leukemia (CLL) presents with dyspnea on exertion, conjunctival pallor and scleral icterus, and moderate anemia with elevated reticulocytes and LDH and a 3+ anti-IgG direct antiglobulin test (DAT). How do you interpret the results?
This cost-effectiveness analysis uses a decision analytic model to extrapolate trial evidence to estimate the long-term survival and value of tisagenlecleucel for children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia.
A middle-aged man presents with painless blurry vision in the left eye and bilateral subretinal fluid in the macula. Late-phase fluorescein angiography reveals multifocal pinpoint areas of hyperfluorescence with mild leakage. What would you do next?
A 3-year-old girl with B-cell acute lymphoblastic leukemia and no known skin trauma presented with an asymptomatic skin lesion with violaceous to black plaque, a central hemorrhagic bulla, and surrounding hyperemia on the left lower back. What is your diagnosis?
This cohort study assesses the association of bacteremic sepsis during treatment for acute lymphoblastic leukemia with long-term neurocognitive dysfunction among children.
This narrative review discusses the pathophysiology of adult acute lymphoblastic leukemia and recent progress in the development of personalized therapies.
This open-label randomized clinical trial involving pediatric patients with acute leukemia receiving intensive chemotherapy or undergoing hematopoietic stem cell transplantation compares the rate of bacteremia among those who received levofloxacin prophylaxis with those who did not.
This registry-based study compares survival in patients with acute myelogenous leukemia who have undergone a second allogeneic hematopoietic cell transplant vs donor lymphocyte infusion after relapse.
A man in his 20s with acute myeloid leukemia presented with rapidly growing, severely painful oral lesions on the left hard palate. What is your diagnosis?
This analysis of data from a phase 1/2 study evaluates potential cases of isocitrate dehydrogenase differentiation syndrome among patients treated with enasidenib for relapsed/refractory acute myeloid leukemia.
This cohort study evaluates the association of cerebrospinal fluid biomarkers of brain injury with short- and long-term outcomes and genetic polymorphisms in children receiving chemotherapy for acute lymphoblastic leukemia.
This Patient Page explains tumor lysis syndrome, how it affects the body, who is at greatest risk, how to recognize it, and measures to help prevent it or treat it.
This review compares the basic features of pediatric and adult chemotherapy regimens for acute lymphoblastic leukemia and lymphoblastic lymphoma, recognizes and describes the challenges of the pediatric regimen, and suggests strategies to facilitate its adoption.
This ad hoc analysis of data from 2 clinical trials examines factors that may predict complete response in patients with chronic lymphocytic leukemia or small lymphocytic leukemia treated with ibrutinib.
A 25-year-old man with acute lymphoblastic leukemia presented with blurry vision in the left eye for 24 hours and gradually worsening floaters for 1 week. What would you do next?
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