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    Opioids

    Explore the latest in opioid use disorders, including recent advances in opioid rehabilitation programs, treatments, and public health interventions.

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    • Office-Based Addiction Treatment Retention and Mortality Among People Experiencing Homelessness
      JAMA Network Open
      Research
      March 4, 2021

      This cohort study examines the association between mortality and retention within office-based addiction treatment settings in individuals with opioid use disorder who are experiencing homelessness.

      Substance Use and Addiction Public Health Toxicology
      Full Text | pdf link PDF open access
    • Prevalence and Childhood Precursors of Opioid Use in the Early Decades of Life
      JAMA Pediatrics
      Research
      March 1, 2021

      This cohort study documents age-related changes in opioid use and analyzes childhood antecedents of opioid use among non-Hispanic White individuals and American Indian individuals.

      Substance Use and Addiction Child and Adolescent Psychiatry Pediatrics Adolescent Medicine Psychiatry
      Full Text | pdf link PDF | CME & MOC open access is active quiz
    • Removing One Barrier to Opioid Use Disorder Treatment: Is It Enough?
      JAMA
      Opinion
      February 25, 2021

      This Viewpoint discusses policy reforms necessary to advance medical management of opioid use disorder in the wake of retraction by the Biden adminstration of proposed federal Practice Guidelines for the Administration of Buprenorphine for Treating Opioid Use Disorder.

      Substance Use and Addiction Health Care Policy Health Policy
      Full Text | pdf link PDF free has multimedia with quiz
    • Overcoming Barriers to Treatment of Opioid Use Disorder
      JAMA
      Opinion
      February 25, 2021

      This Viewpoint discusses federal guidance that would exempt physicians from a standing requirement to apply for a waiver to prescribe buprenorphine for opioid use disorder (OUD) and makes additional recommendations to expand access to medication treatment of OUD, including expanded prescriber training and office-based methadone treatment.

      Substance Use and Addiction Health Care Policy Health Policy
      Full Text | pdf link PDF free has multimedia with quiz
    • Pharmacological Interventions for Breathlessness—Absence of Effect or Absence of Evidence?
      JAMA Network Open
      Opinion
      February 25, 2021
      Clinical Pharmacy and Pharmacology Substance Use and Addiction Pharmacy and Clinical Pharmacology Oncology
      Full Text | pdf link PDF open access
    • Pharmacologic Interventions for Breathlessness in Patients With Advanced Cancer: A Systematic Review and Meta-analysis
      JAMA Network Open
      Research
      February 25, 2021

      This systematic review assesses the benefits and harms of pharmacologic interventions for breathlessness in adults with advanced cancer.

      Clinical Pharmacy and Pharmacology Oncology Pharmacy and Clinical Pharmacology Substance Use and Addiction
      Full Text | pdf link PDF open access
    • Association of Opioid Use Disorder Treatment With Alcohol-Related Acute Events
      JAMA Network Open
      Research
      February 24, 2021

      This case-control cohort study examines whether the use of medications to treat opioid use disorder is associated with decreased risk for alcohol-related falls or injuries and poisonings in persons with opioid use disorder with and without co-occurring alcohol use disorder.

      Substance Use and Addiction Toxicology Alcohol
      Full Text | pdf link PDF open access
    • Prevalence of Prenatal Opioid Exposure in Ontario, Canada, 2014-2019
      JAMA Network Open
      Research
      February 17, 2021

      This population-based cohort study assesses the prevalence of opioid use in pregnant women in Ontario, Canada, from 2014 through 2019.

      Pediatrics Pregnancy Substance Use and Addiction Toxicology Antenatal Exposures and Child Outcomes
      Full Text | pdf link PDF open access
    • Interventions to Address the Opioid Crisis—Modeling Predictions and Consequences of Inaction
      JAMA Network Open
      Opinion
      February 15, 2021
      Toxicology Health Care Policy Health Policy Substance Use and Addiction Psychiatry
      Full Text | pdf link PDF open access
    • Projected Estimates of Opioid Mortality After Community-Level Interventions
      JAMA Network Open
      Research
      February 15, 2021

      This decision analytical model examines the association of evidence-based practices alone or in combination with reduction of opioid overdose mortality by at least 40% in simulated communities.

      Substance Use and Addiction Health Care Policy Health Policy Toxicology
      Full Text | pdf link PDF open access has multimedia
    • Systematic Evaluation of State Policy Interventions Targeting the US Opioid Epidemic, 2007-2018
      JAMA Network Open
      Research
      February 12, 2021

      This cross-sectional study assesses state drug policies implemented between 2007 and 2018 to ascertain whether they are associated with variations in opioid misuse, opioid use disorder, and drug overdose mortality.

      Psychiatry Toxicology Health Care Policy Health Policy Substance Use and Addiction
      Full Text | pdf link PDF open access
    • Continued Increases in Overdose Deaths Related to Synthetic Opioids: Implications for Clinical Practice
      JAMA
      Opinion
      February 11, 2021

      This Viewpoint summarizes a 2021 MMWR report documenting a concerning rise in illicit and synthetic opioid overdose deaths in the US between 2013 and 2019 and proposes strategies to connect clinicians and health systems with public health, public safety, and other community partners to share data, monitor trends, and better respond to the overdose epidemic.

      Toxicology Health Care Policy Public Health Health Policy Emergency Medicine
      Full Text | pdf link PDF free
    • Accelerated Overdose Deaths Linked With COVID-19
      JAMA
      News
      February 9, 2021
      Substance Use and Addiction Coronavirus (COVID19)
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • Trends in Heroin Treatment Admissions in the United States by Race, Sex, and Age
      JAMA Network Open
      Research
      February 5, 2021

      This cross-sectional study examines trends in heroin treatment admission rates in the United States by race, sex, and age from 2000 to 2017.

      Substance Use and Addiction Pain Medicine
      Full Text | pdf link PDF open access
    • Trends in US Emergency Department Visits for Mental Health, Overdose, and Violence Outcomes Before and During the COVID-19 Pandemic
      JAMA Psychiatry
      Research
      February 3, 2021

      This cross-sectional analysis uses data from the Centers for Disease Control and Prevention to examine changes in US emergency department visits for mental health, suicide attempts, overdose, and violence outcomes during the COVID-19 pandemic.

      Toxicology Infectious Diseases Pulmonary Medicine Coronavirus (COVID19) Psychiatry
      Full Text | pdf link PDF | CME & MOC free is active quiz has multimedia with quiz
    • Tighter Requirements to Ensure Safer Opioid Prescribing
      JAMA
      News
      February 2, 2021
      Substance Use and Addiction Regulatory Agencies Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF
    • Polysubstance Involvement in Opioid Overdose Deaths in Adolescents and Young Adults, 1999-2018
      JAMA Pediatrics
      Research
      February 1, 2021

      This cross-sectional study examines US trends in polysubstance-involved opioid overdose deaths among adolescents and young adults aged 13 to 25 years.

      Emergency Medicine Psychiatry Substance Use and Addiction Child and Adolescent Psychiatry Toxicology
      Full Text | pdf link PDF
    • Eastern Kentucky’s Lost Generation and the Echoes That Remain—The Aftermath of the Opioid Epidemic
      JAMA Internal Medicine
      Opinion
      February 1, 2021

      This essay describes the author’s personal experiences witnessing the opioid epidemic and its devastation in Kentucky.

      Humanities Narrative Medicine Substance Use and Addiction Public Health Perspective
      Full Text | pdf link PDF
    • Five Things to Know When a Psychiatric Patient Is Prescribed Opioids for Pain
      JAMA Psychiatry
      Review
      February 1, 2021

      This essay describes how psychiatrists can play an important role in optimizing care for patients who have been prescribed opioids for chronic pain.

      Pain Medicine Substance Use and Addiction
      Full Text | pdf link PDF
    • Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis
      JAMA Psychiatry
      Research
      February 1, 2021

      This mendelian randomization analysis investigates the potential bidirectional associations between the genetic liability for prescription opioid and other nonopioid pain medications and both major depressive disorder and anxiety and stress-related disorders using genetically based methods

      Genetics and Genomics Pain Medicine Substance Use and Addiction Psychiatry Depressive Disorders
      Full Text | pdf link PDF open access
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