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    Opioids

    Explore the latest in opioid use disorders, including recent advances in opioid rehabilitation programs, treatments, and public health interventions.

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    • Association Between Hospital Adoption of an Emergency Department Treatment Pathway for Opioid Use Disorder and Patient Initiation of Buprenorphine After Discharge
      JAMA Health Forum
      Research
      March 24, 2023

      This cohort study evaluates the association between hospitals attesting to an opioid use disorder (OUD) emergency department (ED) treatment pathway and patients’ initiation of buprenorphine treatment.

      Health Policy Emergency Medicine Substance Use and Addiction Medicine
      Full Text | pdf link PDF open access
    • Association of Patients’ Direct Addition of Buprenorphine to Urine Drug Test Specimens With Clinical Factors in Opioid Use Disorder
      JAMA Psychiatry
      Research
      March 22, 2023

      This cross-sectional study characterizes factors associated with the direct addition of buprenorphine to urine specimens in individuals prescribed buprenorphine for opioid use disorder.

      Substance Use and Addiction Medicine
      Full Text | pdf link PDF
    • Association of Household Opioid Availability With Opioid Overdose
      JAMA Network Open
      Research
      March 17, 2023

      This cohort study examines the risk for opioid overdose associated with the presence of opioids within the household.

      Substance Use and Addiction Medicine Public Health Toxicology
      Full Text | pdf link PDF open access
    • Association of Implementation of Postoverdose Outreach Programs With Subsequent Opioid Overdose Deaths Among Massachusetts Municipalities
      JAMA Psychiatry
      Research
      March 15, 2023

      This time-series analysis assesses the association of implementation of postoverdose outreach programs with opioid fatality rates in Massachusetts municipalities with high numbers of opioid-related medical emergency services responses.

      Substance Use and Addiction Medicine Toxicology
      Full Text | pdf link PDF has multimedia
    • Bupropion Slow Release vs Placebo With Adaptive Incentives for Cocaine Use Disorder in Persons Receiving Methadone for Opioid Use Disorder: A Randomized Clinical Trial
      JAMA Network Open
      Research
      March 15, 2023

      This randomized clinical trial compares the effect of abstinence incentives combined with either bupropion slow release or placebo on cocaine abstinence outcomes among individuals receiving methadone treatment for opioid use disorder.

      Substance Use and Addiction Medicine
      Full Text | pdf link PDF open access
    • Universal Precautions for People at Risk of Opioid Overdose in North America
      JAMA Internal Medicine
      Opinion
      March 13, 2023

      This viewpoint discusses and suggests clinical interventions to be implemented by clinicians and health systems in North America to reduce opioid overdose deaths among at-risk patients.

      Substance Use and Addiction Medicine Public Health Toxicology
      Full Text | pdf link PDF
    • Mortality Trends Among Adults Experiencing Homelessness in Boston, Massachusetts From 2003 to 2018
      JAMA Internal Medicine
      Research
      March 13, 2023

      This cohort study involves assessing causes of death among people experiencing homelessness in Boston from 2003 to 2018.

      Health Disparities Substance Use and Addiction Medicine Toxicology Equity, Diversity, and Inclusion Public Health
      Full Text | pdf link PDF
    • Association of Primary Care Visit Length With Potentially Inappropriate Prescribing
      JAMA Health Forum
      Research
      March 10, 2023

      This cross-sectional study of a multistate sample of electronic health record data examines the association between primary care visit length and potentially inappropriate prescribing.

      Health Policy Health Inequities Health Disparities Health Care Quality Antibiotic Use, Overuse, Resistance, Stewardship
      Full Text | pdf link PDF open access
    • Quality of Opioid Use Disorder Treatment for Persons With and Without Disabling Conditions
      JAMA Network Open
      Research
      March 8, 2023

      This case-control study examines the use and quality of treatment for opioid use disorder in adults with diagnosed disabling conditions, compared with adults without these diagnoses.

      Equity, Diversity, and Inclusion Health Disparities Substance Use and Addiction Medicine Health Policy Health Inequities
      Full Text | pdf link PDF open access
    • A 2023 Agenda for Substance Use Prevention and Treatment in the US
      JAMA
      Opinion
      March 7, 2023

      In this Viewpoint, officials from the White House Office of National Drug Control Policy describe 3 actions that health care personnel can take to expand prevention and treatment of substance misuse and overdose.

      Public Health Health Policy Substance Use and Addiction Medicine
      Full Text | pdf link PDF
    • Implementing the White House’s Strategic Plan to Save Lives Amid the Opioid Crisis: Reaching for the “North Star”
      JAMA
      Opinion
      March 7, 2023

      This Viewpoint discusses the goals of the inaugural National Drug Control Strategy, which as the ambitious agenda of emphasizing harm reduction practices, medications for treating opioid use disorder, and criminal justice reform, as well as supporting long-term recovery and interrupting illicit drug trafficking.

      Law and Medicine Public Health Health Policy Substance Use and Addiction Medicine
      Full Text | pdf link PDF
    • States’ Methods for Capturing and Reporting Local Responses to Suspected Nonfatal Drug Overdoses
      JAMA
      Research
      March 7, 2023

      This study examines the available data used to surveil state-level drug overdoses and characterizes them based on their timeliness, drug involvement, and specification of nonfatal outcomes.

      Substance Use and Addiction Medicine Toxicology Public Health Health Policy Health Informatics
      Full Text | pdf link PDF
    • Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure
      JAMA
      Research
      March 7, 2023

      This interrupted time-series analysis uses data from the National Inpatient Sample and the Acute Liver Failure Study Group to assess the odds of hospitalization and the proportion of acute liver failure cases with acetaminophen and opioid toxicity prior to and after the US Food and Drug Administration mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications.

      Law and Medicine Substance Use and Addiction Medicine Public Health Health Policy Population Health
      Full Text | pdf link PDF has multimedia
    • High-Dose Buprenorphine Initiation in the Emergency Department Among Patients Using Fentanyl and Other Opioids
      JAMA Network Open
      Research
      March 3, 2023

      This cohort study examines buprenorphine treatment initiation, response, and follow-up among patients presenting to California emergency departments (EDs) who reported fentanyl or other opioid use.

      Substance Use and Addiction Medicine Emergency Medicine
      Full Text | pdf link PDF open access
    • Assessment of an Opioid Stewardship Program on Perioperative Opioid Prescribing in a Safety-Net Health System
      JAMA Surgery
      Research
      March 1, 2023

      This quality improvement study involves comparison of opioid prescription data before and after implementation of an opioid stewardship program in a safety-net medical system.

      Anesthesiology Substance Use and Addiction Medicine Health Care Quality Surgery Perioperative Care and Consultation
      Full Text | pdf link PDF
    • Redesigning Opioid Pain Agreements to Promote Patient-Centered Care
      JAMA Internal Medicine
      Opinion
      March 1, 2023

      This Viewpoint discusses opioid pain agreements to promote patient-centered care.

      Pain Medicine Substance Use and Addiction Medicine
      Full Text | pdf link PDF
    • Trends in Out-of-Pocket Costs for and Characteristics of Pharmacy-Dispensed Buprenorphine Medications for Opioid Use Disorder Treatment by Type of Payer, 2015 to 2020
      JAMA Network Open
      Research
      February 10, 2023

      This cross-sectional study evaluates trends in out-of-pocket costs for and characteristics of pharmacy-dispensed buprenorphine medications for opioid use disorder treatment by type of payer from 2015 to 2020.

      Health Care Economics, Insurance, Payment Pharmacoeconomics Health Policy Pharmacy and Clinical Pharmacology Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Implementation and Assessment of No Opioid Prescription Strategy at Discharge After Major Urologic Cancer Surgery
      JAMA Surgery
      Research
      February 8, 2023

      This cohort study assesses a protocol for eliminating postdischarge opioid prescriptions after major urologic cancer surgery by assessing patients who receive usual, reduced, or no opioids.

      Surgery Surgical Oncology Urology Urologic Cancer Perioperative Care and Consultation
      Full Text | pdf link PDF
    • Association Between Opioid Tapering and Subsequent Health Care Use, Medication Adherence, and Chronic Condition Control
      JAMA Network Open
      Research
      February 7, 2023

      This cohort study examines outcomes associated with tapering of opioid therapy in patients who have received stable doses for 1 year, including subcohorts of those with hypertension or diabetes.

      Pharmacy and Clinical Pharmacology Clinical Pharmacy and Pharmacology Treatment Adherence Diabetes Diabetes and Endocrinology
      Full Text | pdf link PDF open access
    • Letters to Clinicians May Promote Better-Informed Opioid Prescribing
      JAMA
      News
      February 7, 2023
      Substance Use and Addiction Medicine Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF
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