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    Pericardial Disease

    Explore the latest in pericardial disease, including diagnosis and management of pericarditis, pericardial effusion, and tamponade.

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    • Malignant Pericardial Effusion, or Fluid Around the Heart Due to Cancer
      JAMA Oncology
      Patient Information
      November 16, 2023

      This JAMA Oncology Patient Page describes the accumulation of excess fluid around the heart caused by cancer, known as malignant pericardial effusion.

      Oncology Patient Information JAMA Oncology Patient Information Cardiology
      Full Text | pdf link PDF free
    • A Patient in Their 70s With Bright Red Blood in the Pericardiocentesis Catheter
      JAMA Cardiology
      Case Report
      September 1, 2023

      This case report discusses a finding of blood in the pericardiocentesis catheter of a patient with a recent history of aortic valve replacement and recurrent postsurgical pericardial and pleural effusions.

      Cardiology Cardiovascular Images Cardiothoracic Surgery Surgery
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Migrating Localized ST-Segment Elevation With Ongoing Chest Pain
      JAMA Internal Medicine
      Case Report
      September 1, 2023

      A patient in their 60s presented with a 6-hour history of sudden-onset worsening chest pain associated with shortness of breath and diaphoresis. What is your diagnosis?

      Cardiology Emergency Medicine Challenges in Clinical Electrocardiography
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Myocarditis or Pericarditis Events After BNT162b2 Vaccination in Individuals Aged 12 to 17 Years in Ontario, Canada
      JAMA Pediatrics
      Research
      April 1, 2023

      This cohort study investigates the association of myocarditis or pericarditis with BNT162b2 vaccination in adolescents aged 12 to 17 years.

      Vaccination Public Health Coronavirus (COVID-19) Cardiology Pediatrics
      Full Text | pdf link PDF open access
    • Testing for EGFR Variants in Pleural and Pericardial Effusion Cell-Free DNA in Patients With Non–Small Cell Lung Cancer
      JAMA Oncology
      Research
      February 1, 2023

      This diagnostic study of patients in China assesses the accuracy of droplet digital polymerase chain reaction testing of cell-free DNA from pleural and pericardial effusion in detecting EGFR variants in patients with advanced non–small cell lung cancer.

      Cancer Biomarkers Genetics and Genomics Lung Cancer Oncology Pulmonary Medicine
      Full Text | pdf link PDF free
    • Myopericarditis After COVID-19 mRNA Vaccination Among Adolescents and Young Adults: A Systematic Review and Meta-analysis
      JAMA Pediatrics
      Research
      January 1, 2023

      This systematic review and meta-analysis investigates the clinical features and early outcomes associated with myopericarditis after COVID-19 mRNA vaccination in a heterogeneous population of adolescents and young adults.

      Vaccination Adolescent Medicine Pediatrics Coronavirus (COVID-19) Cardiology
      Full Text | pdf link PDF free
    • A Man in His 50s With Cardiac Tamponade From Ruptured Coronary Artery Aneurysm
      JAMA Cardiology
      Case Report
      November 9, 2022

      This case report describes a diagnosis of cardiac tamponade secondary to ruptured coronary artery aneurysm in a man who presented with acute chest pain and dyspnea.

      Cardiology Ischemic Heart Disease Cardiovascular Images
      Full Text | pdf link PDF has multimedia
    • Advances in Imaging and Targeted Therapies for Recurrent Pericarditis: A Review
      JAMA Cardiology
      Review
      September 1, 2022

      This narrative review offers a guide for clinicians on the current diagnostic and therapeutic approach for recurrent pericarditis with emphasis on what is new since the 2015 European Society of Cardiology guidelines.

      Cardiology Cardiac Imaging Radiology Pharmacy and Clinical Pharmacology Cardiovascular Images
      Full Text | pdf link PDF has multimedia
    • Epidemiology of Myocarditis and Pericarditis Following mRNA Vaccination by Vaccine Product, Schedule, and Interdose Interval Among Adolescents and Adults in Ontario, Canada
      JAMA Network Open
      Research
      June 24, 2022

      This cohort study estimates rates of myocarditis and pericarditis after receipt of an mRNA COVID-19 vaccine among individuals in Ontario, Canada, stratified by recipients’ age and sex and by the vaccine product, schedule, and interdose interval.

      Public Health Pharmacy and Clinical Pharmacology Adolescent Medicine Cardiology Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Myocarditis or Pericarditis Following mRNA COVID-19 Vaccination
      JAMA Network Open
      Opinion
      June 24, 2022
      Public Health Pharmacy and Clinical Pharmacology Adolescent Medicine Clinical Pharmacy and Pharmacology Pediatrics
      Full Text | pdf link PDF open access
    • Percutaneous Intramyocardial Septal Radiofrequency Ablation in Patients With Drug-Refractory Hypertrophic Obstructive Cardiomyopathy
      JAMA Cardiology
      Research
      May 1, 2022

      This cohort study assesses the safety and medium-term outcomes of percutaneous intramyocardial septal radiofrequency ablation in a large patient cohort with drug-refractory hypertrophic obstructive cardiomyopathy.

      Cardiology Rhythm Disorders
      Full Text | pdf link PDF free has multimedia
    • Diagnostic Dilemma of Pericarditis Concurrent With ST Elevation Myocardial Infarction
      JAMA Internal Medicine
      Case Report
      May 1, 2022

      This case report presents the electrocardiogram findings of a 57-year-old man with persistent diffuse ST elevation after failed treatment with streptokinase therapy.

      Emergency Medicine Challenges in Clinical Electrocardiography Acute Coronary Syndromes Ischemic Heart Disease Cardiology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • A Man in His 60s With Pneumonia and Multiple Reintubation Attempts
      JAMA Cardiology
      Case Report
      March 9, 2022

      This case report describes a diagnosis of pneumopericardium in a man in his 60s after multiple reintubation attempts owing to respiratory failure from pneumonia.

      Infectious Diseases Pulmonary Medicine Pneumonia Cardiovascular Images Cardiology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Distinguishing Constrictive Pericarditis From Restrictive Cardiomyopathy—An Ongoing Diagnostic Challenge
      JAMA Cardiology
      Opinion
      January 1, 2022
      Cardiology
      Full Text | pdf link PDF
    • A Simplified Method for the Diagnosis of Constrictive Pericarditis in the Cardiac Catheterization Laboratory
      JAMA Cardiology
      Research
      January 1, 2022

      This diagnostic study evaluates a simplified method for the diagnosis of constrictive pericarditis.

      Cardiology
      Full Text | pdf link PDF free
    • Myocarditis and Pericarditis After Vaccination for COVID-19
      JAMA
      Research
      September 28, 2021

      This study investigates the incidence of myocarditis and pericarditis emergency department or inpatient hospital encounters before COVID-19 vaccine availability (January 2019–January 2021) and during a COVID-19 vaccination period (February-May 2021) in a large US health care system.

      Vaccination Cardiology Coronavirus (COVID-19) Public Health
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • Causative Mechanism of Constrictive Pericarditis Diagnosed by Fluoroscopy
      JAMA Cardiology
      Case Report
      April 12, 2021

      This case report describes a patient with constrictive pericarditis after recurrent peritonitis associated with peritoneal dialysis for end-stage kidney disease.

      Cardiology Cardiovascular Images
      Full Text | pdf link PDF
    • A 61-Year-Old Woman With New Pericardial Effusion
      JAMA Cardiology
      Case Report
      March 1, 2020

      A 61-year-old woman presents with pleuritic chest pain, shortness of breath, and syncope in addition to having an inferior vena cava stent placement 9 years prior. What would you do next?

      Cardiology Cardiothoracic Surgery Surgery Clinical Challenge
      Full Text | pdf link PDF has multimedia
    • A Diffuse Medullary Hypercaptation With No Bone Lesion
      JAMA Oncology
      Case Report
      February 1, 2020

      A 71-year-old man presented with a 3-year history of pericarditis and pleural effusions; imaging and biopsy results showed diffuse medullary hypercaptation in the bone marrow and spleen. What is your diagnosis?

      Oncology Pathology and Laboratory Medicine Clinical Challenge Cardiology Hematology
      Full Text | pdf link PDF
    • Adenosine Deaminase Diagnostic Testing in Pericardial Fluid
      JAMA
      Case Report
      July 9, 2019

      A 65-year-old man from Vietnam presented with shortness of breath at rest, orthopnea, and lower extremity edema for the past 2 weeks and nonproductive cough and weight loss for the past 4 months. A computed tomographic (CT) scan demonstrated a moderate to large pericardial effusion that was lymphocyte-predominant with a fluid ADA level of 118.1 U/L. What would you do next?

      Cardiology Pathology and Laboratory Medicine Clinical Challenge Diagnostic Test Interpretation Infectious Diseases
      Full Text | pdf link PDF
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