Explore the latest in antibiotic use, overuse, resistance, and stewardship, including evolving antimicrobial susceptibility patterns and more.
This randomized clinical trial investigates whether withholding the standard 48 hours of intravenous empirical antibiotics immediately after birth in preterm infants protects the developing microbiome and improves clinical outcomes.
This cohort study assesses the antibiotic susceptibility patterns of Escherichia coli among infants admitted to US neonatal intensive care units from 2009 to 2017.
This cohort study compares definitive therapy with oral β-lactam antibiotics vs fluoroquinolones or trimethoprim-sulfamethoxazole after 1 to 5 days of parenteral antibiotics for Enterobacterales bacteremia from a suspected urine source.
This observational cohort study compares the odds of cardiac events among new users of azithromycin relative to new users of amoxicillin using real-world data.
This case-control study estimates the risk of aortic aneurysm or aortic dissection associated with infections and the comparative risk associated with fluoroquinolones vs other antibiotics with similar indication profiles among patients with the same types of infections.
This cohort study examines the risk for aortic aneurysm or aortic dissection in patients receiving fluoroquinolones for treatment of pneumonia or urinary tract infection.
This cohort study examines the association of hydroxychloroquine or hydroxychloroquine and azithromycin with QT prolongation in adult patients hospitalized with coronavirus disease 2019.
This network meta-analysis compares the efficacy and safety of 8 antibiotics used for treatment of scrub typhus.
This nonrandomized controlled trial allowed children with appendicitis and their families to choose antibiotic therapy vs laparoscopic appendectomy as initial management, and compares 1-year disability days and treatment success—no need for later surgery—between the groups.
This population-based cohort study assesses the 30-day risk of hospital admission with hemorrhage after coprescription of clarithromycin compared with azithromycin among older adults taking a direct oral anticoagulant.
This cohort study assesses the prevalence and association of documented penicillin allergy with inpatient antibiotic use in the US.
This cohort study examines the prescribing rates and duration of antibiotic therapy in patients with possible pneumonia whose clinical signs are within the reference ranges.
This randomized clinical trial compares the effects of daily combination probiotics (Lactobacillus and Bifidobacterium spp) vs placebo on cumulative antibiotic use for all-cause infections over 1 year among care home residents in Wales.
This quality improvement study examines the association of a multifaceted antimicrobial stewardship and quality improvement intervention with the reduction in unnecessary antimicrobial use for unlikely cystitis among noncatheterized nursing home residents.
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