Explore the latest in antibiotic use, overuse, resistance, and stewardship, including evolving antimicrobial susceptibility patterns and more.
This systematic review and meta-analysis compares the pooled results of randomized clinical trials that examined the effect of antibiotic preventive therapy on postoperative complications in patients undergoing rhinoplasty.
This Medical News article discusses why many patients have mistakenly been labeled as allergic to penicillin and the impact that can have on their health.
This double-blind, randomized clinical noninferiority trial evaluates whether placebo treatment is significantly inferior to 3 days of oral amoxicillin treatment in HIV-uninfected children aged 2 to 59 months with nonsevere fast-breathing pneumonia in a malaria-endemic region of Malawi, Africa.
This study assesses the association between antibiotic prescribing for respiratory tract infections and satisfaction ratings among patients using a direct-to-consumer telemedicine platform.
This network meta-analyses of 19 randomized clinical trials conducted in the United States and Europe examines antibiotic agents and treatment modalities to assess treatment effectiveness and drug-related adverse outcomes in early cutaneous Lyme borreliosis.
This cohort study develops 2 clinical risk scores based on variables available at clinical presentation to estimate the risk of carbapenem resistance or extensive β-lactam resistance among hospitalized adult patients with Pseudomonas aeruginosa infections.
This network meta-analysis of randomized clinical trials assesses which approach in colorectal surgery (mechanical bowel preparation with and without oral antibiotics) is associated with the lowest rate of surgical site infections.
This cohort study describes the rates of major surgical site infection for patients undergoing cochlear implantation who receive prolonged antibiotic treatment compared with those who receive a single perioperative dose of antibiotic prophylaxis.
This Viewpoint makes the case that the importance of early detection of sepsis and the need for rapid antibiotics in patients with definite infection and possible septic shock has likely led to overuse of antibiotics in patients who might not need them, and argues for testing to confirm infection in non-shock patients in place of rapid empirical antimicrobial treatment.
This noninferiority trial compares the effects on clinical success and adverse events of an algorithm that defines diagnostic evaluation, antibiotic selection, and duration of therapy for staphylococcal bacteremia vs standard clinical care.
During a 5-year follow-up of patients initially treated with antibiotics for uncomplicated acute appendicitis, this observational study assesses the rate of late recurrence.
This noninferiority trial compares the effects of piperacillin-tazobactam vs meropenem on mortality in patients with bloodstream infection caused by ceftriaxone-nonsusceptible Escherichia coli or Klebsiella pneumoniae.
This cohort study compares antibiotic prescribing in 2014 among retail clinics, urgent care centers, emergency departments, and traditional medical offices in the United States.
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