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    Hepatitis B

    Explore the latest in hepatitis B, including recent advances in diagnosis and antiviral treatment, prevention of complications, and more.

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    • Association of Heavy Alcohol Intake and ALDH2 rs671 Polymorphism With Hepatocellular Carcinoma and Mortality in Patients With Hepatitis B Virus–Related Cirrhosis
      JAMA Network Open
      Research
      July 25, 2022

      This cohort study investigates the association of heavy alcohol intake, aldehyde dehydrogenase 2 gene (ALDH2) rs671 polymorphism, and hepatitis B virus infection with hepatocellular carcinoma development and mortality in patients with cirrhosis.

      Gastroenterology and Hepatology Hepatobiliary Disease Viral Hepatitis Infectious Diseases Genetics and Genomics
      Full Text | pdf link PDF open access
    • Association of Nationwide Hepatitis B Vaccination and Antiviral Therapy Programs With End-Stage Liver Disease Burden in Taiwan
      JAMA Network Open
      Research
      July 18, 2022

      This cohort study examines the associations of nationwide hepatitis B vaccination and antiviral therapy programs implemented in Taiwan with the burden of end-stage liver disease by age, period, and cohort.

      Public Health Gastroenterology and Hepatology Health Policy Hepatobiliary Disease Infectious Diseases
      Full Text | pdf link PDF open access
    • Risk of Hepatocellular Carcinoma With Tenofovir vs Entecavir Treatment for Chronic Hepatitis B Virus: A Reconstructed Individual Patient Data Meta-analysis
      JAMA Network Open
      Research
      June 29, 2022

      This meta-analysis reconstructs individual participant data from high-quality, propensity score–matched cohort studies and provides more accurate and precise estimates of hepatocellular carcinoma (HCC) risk among patients with chronic hepatitis B virus.

      Gastroenterology and Hepatology Pharmacy and Clinical Pharmacology Hepatobiliary Disease Clinical Pharmacy and Pharmacology HIV
      Full Text | pdf link PDF open access
    • A Patient With Jaundice and Malaise
      JAMA
      Case Report
      June 28, 2022

      A woman with a history of intravenous heroin use and chronic inactive hepatitis B virus infection had sudden onset of painless jaundice and malaise. Vital signs, mentation, and physical examination were normal except for scleral icterus; she reported no history of travel outside the US and no raw meat ingestion; aminotransferase and bilirubin levels were newly elevated, but she had no acute hepatitis A or C virus infection. What is the diagnosis and what would you do next?

      Infectious Diseases Clinical Challenge Hepatobiliary Disease Gastroenterology and Hepatology Viral Hepatitis
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Regional Differences in Mortality Rates and Characteristics of Decedents With Hepatitis B Listed as a Cause of Death, United States, 2000-2019
      JAMA Network Open
      Research
      June 28, 2022

      This cross-sectional study assesses characteristics of US decedents with hepatitis B–listed deaths during 2010 to 2019 and compares rates with 2000 to 2009.

      Public Health Gastroenterology and Hepatology Infectious Diseases Viral Hepatitis Hepatobiliary Disease
      Full Text | pdf link PDF open access
    • Age Range Is Expanded for Universal Hepatitis B Vaccination
      JAMA
      News
      May 10, 2022
      Vaccination Viral Hepatitis Hepatobiliary Disease Gastroenterology and Hepatology Infectious Diseases
      Full Text | pdf link PDF
    • Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction
      JAMA
      Research
      April 5, 2022

      This large prospective cohort study compares the rates of acute myocardial infarction between recipients of a 2-dose hepatitis B vaccine and recipients of a 3-dose hepatitis B vaccine.

      Vaccination Viral Hepatitis Ischemic Heart Disease Acute Coronary Syndromes Cardiology
      Full Text | pdf link PDF free
    • Trends in Pricing and Out-of-Pocket Spending on Entecavir Among Commercially Insured Patients, 2014-2018
      JAMA Network Open
      Research
      January 21, 2022

      This cross-sectional study of health claims from patients with private insurance examines trends in the cost of entecavir prescribed for chronic hepatitis B treatment.

      Infectious Diseases Viral Hepatitis Hepatobiliary Disease Health Care Economics, Insurance, Payment Gastroenterology and Hepatology
      Full Text | pdf link PDF open access
    • Serologic Testing for Hepatitis B
      JAMA
      Case Report
      December 21, 2021

      A 27-year-old woman presented with elevated transaminase levels and a positive hepatitis B surface antigen test result. How do you interpret these test results?

      Infectious Diseases Viral Hepatitis Hepatobiliary Disease Gastroenterology and Hepatology Diagnostic Test Interpretation
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Immunogenicity and Safety of a 3-Antigen Hepatitis B Vaccine vs a Single-Antigen Hepatitis B Vaccine: A Phase 3 Randomized Clinical Trial
      JAMA Network Open
      Research
      October 12, 2021

      This randomized clinical trial examines the manufacturing equivalence of a 3-antigen hepatitis B virus (HBV) vaccine and evaluates the noninferiority of its seroprotection rate vs a single-antigen HBV vaccine.

      Infectious Diseases Vaccination Viral Hepatitis Hepatobiliary Disease Gastroenterology and Hepatology
      Full Text | pdf link PDF open access
    • Comparative Efficacy of a High-Dose vs Standard-Dose Hepatitis B Revaccination Schedule Among Patients With HIV: A Randomized Clinical Trial
      JAMA Network Open
      Research
      August 23, 2021

      This randomized clinical trial compares the standard hepatitis B virus (HBV) revaccination schedule for patients with HIV vs a regimen with higher doses.

      Gastroenterology and Hepatology Infectious Diseases Viral Hepatitis Hepatobiliary Disease HIV
      Full Text | pdf link PDF open access
    • Hepatitis B Vaccination in People Living With HIV—If at First You Don’t Succeed, Try Again
      JAMA Network Open
      Opinion
      August 23, 2021
      Gastroenterology and Hepatology Vaccination Viral Hepatitis Hepatobiliary Disease Infectious Diseases
      Full Text | pdf link PDF open access
    • Association of Bcr-Abl Tyrosine Kinase Inhibitors With Hepatitis B Virus Reactivation Requiring Antiviral Treatment in Taiwan
      JAMA Network Open
      Research
      April 6, 2021

      This case-control study examines the association between hepatitis B flare and exposure to Bcr-Abl tyrosine kinase inhibitors (TKIs) compared with non–Bcr-Abl TKIs.

      Pharmacy and Clinical Pharmacology Infectious Diseases Viral Hepatitis Hepatobiliary Disease Gastroenterology and Hepatology
      Full Text | pdf link PDF open access
    • The Updated US Preventive Services Task Force Hepatitis B Screening Recommendations—Staying Committed
      JAMA Internal Medicine
      Opinion
      March 1, 2021
      Infectious Diseases Viral Hepatitis Hepatobiliary Disease Gastroenterology and Hepatology United States Preventive Services Task Force
      Full Text | pdf link PDF has multimedia with quiz
    • Trends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015
      JAMA Network Open
      Research
      February 17, 2021

      This cohort study examines the trends of hepatocellular carcinoma (HCC) incidence rates and compares rates by risk factors among people in the US and Canada with HIV infection in the combination antiretroviral therapy era.

      Infectious Diseases HIV Gastroenterology and Hepatology Viral Hepatitis Hepatobiliary Disease
      Full Text | pdf link PDF open access
    • USPSTF 2020 Hepatitis B Screening Recommendation: Evidence to Broaden Screening and Strengthen Linkage to Care
      JAMA
      Opinion
      December 15, 2020
      Infectious Diseases Pediatrics Viral Hepatitis Hepatobiliary Disease Gastroenterology and Hepatology
      Full Text | pdf link PDF has multimedia with quiz
    • Screening for Hepatitis B in Nonpregnant Adolescents and Adults
      JAMA
      Patient Information
      December 15, 2020

      This JAMA Patient Page reviews the US Preventive Services Task Force’s 2020 recommendation to screen for hepatitis B infection in adolescents and adults at increased risk (B recommendation).

      Patient Information Viral Hepatitis Hepatobiliary Disease Gastroenterology and Hepatology JAMA Patient Information
      Full Text | pdf link PDF free has multimedia with quiz
    • Screening for Hepatitis B Virus Infection in Nonpregnant Adolescents and Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
      JAMA
      Research
      December 15, 2020

      This systematic review to support the 2020 US Preventive Services Task Force Recommendation Statement on screening for hepatitis B virus infection summarizes published evidence on the benefits and harms of screening and interventions for hepatitis B infection in nonpregnant adolescents and adults.

      Infectious Diseases Viral Hepatitis Gastroenterology and Hepatology Hepatobiliary Disease United States Preventive Services Task Force
      Full Text | pdf link PDF free has multimedia with quiz
    • Screening for Hepatitis B Virus Infection in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement
      JAMA
      Research
      December 15, 2020

      This 2020 US Preventive Services Task Force Recommendation Statement recommends screening for HBV infection in adolescents and adults at increased risk for infection (B recommendation).

      Infectious Diseases Viral Hepatitis Gastroenterology and Hepatology United States Preventive Services Task Force Guidelines
      Full Text | pdf link PDF | CME & MOC free is active quiz has multimedia with quiz
    • Association of Number of Doses With Hepatitis B Vaccine Series Completion in US Adults
      JAMA Network Open
      Research
      November 30, 2020

      This cohort study uses data from the electronic health records of Kaiser Permanente Southern California members to assess whether the number of doses in a hepatitis B virus vaccine series is associated with completion of the series among US adults.

      Infectious Diseases Vaccination Workflow and Process Viral Hepatitis Hepatobiliary Disease
      Full Text | pdf link PDF open access
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