Explore the latest in progressive supranuclear palsy, including advances in understanding its epidemiology, etiology, diagnosis, and management.
This case-control study investigates cerebrospinal fluid levels of neurofilament light protein in participants with various forms of dementia, motor neuron disease, and movement disorders and controls, as determined by clinical and autopsy-definite criteria.
This narrative review describes the evidence for propagation of distinct tau strains in Alzheimer disease and mechanistic insights into cell-to-cell transmission of pathological tau in multiple neurodegenerative diseases, including Alzheimer disease, progressive supranuclear palsy, corticobasal degeneration, and Pick disease.
This brain bank case-control study analyzes disease-specific inclusions in the key structures of the circadian system in patients with Parkinson disease, multiple system atrophy, and progressive supranuclear palsy.
This case report describes autopsy findings of progressive supranuclear palsy in a patient with a misdiagnosis of multiple system atrophy with predominant parkinsonism.
This clinical-pathological study characterizes the neurological, cognitive, and neuroimaging features of patients with nonfluent/agrammatic primary progressive aphasia—in whom either progressive supranuclear palsy or corticobasal degeneration was eventually confirmed at autopsy—at initial presentation and at 1-year follow-up and identifies features associated with underlying pathology.
Caroppo et al analyzed the DCTN1 gene in families with a progressive supranuclear palsy–like phenotype at a referral center among 21 patients. In addition, 8 patients and relatives from a family carrying a DCTN1 mutation were evaluated. Outcome measures were identification of the DCTN1 mutation and clinical description of DCTN1 mutation carriers.
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