Explore the latest in CNS infections from The JAMA Network, including emerging viral and opportunistic infections, prion diseases, and more.
A 30-year-old woman with a remote history of Hemophilus influenzae type b meningitis causing quadraparesis was admitted to the hospital with Candida fungemia.
This cohort study evaluates the rates of acute Zika virus infection among patients hospitalized with Guillain-Barré syndrome, meningoencephalitis, or transverse myelitis.
A 14-year-old girl presents with fever, malaise, photophobia, phonophobia, headache, nausea, vomiting, and neck stiffness. What would you do next?
This cohort study estimates the accuracy of individual complete blood cell count parameters to identify febrile infants with invasive bacterial infections.
This cohort study assesses the role of the central nervous system as a potential reservoir for Ebola virus after initial clinical recovery in a population of patients who survived Ebola virus disease.
A 30-year-old man was referred with progressive quadriplegia that started from the right lower limb and gradually spread to the upper limb and contralateral side. Cerebrospinal fluid testing revealed pleocytosis, elevated protein concentration, and a decreased glucose level, and magnetic resonance imaging of the cervical spine revealed multiple intramedullary lesions. What is your diagnosis?
A man in his 50s with an unremarkable medical history began experiencing vertigo 1 week after a viral upper respiratory tract infection.
This case report describes the process of determining which pathogen caused a woman in her 60s to present with symptoms of chronic meningitis.
This case report describes a woman in her 40s who was admitted after 4 months of headache, fatigue, and weight loss.
This case-control study assesses an algorithm for diagnosis of Creutzfeldt-Jakob disease using cerebrospinal fluid and olfactory mucosa samples among patients with possible, probable, or suspected disease.
This case series describes the prenatal evolution and perinatal outcomes of 11 neonates who had developmental abnormalities and neurological damage associated with maternal Zika virus infection in Brazil.
This cross-sectional study assesses the feasibility of sporadic Creutzfeldt-Jakob disease diagnosis by adaptation of an established variant Creutzfeldt-Jakob disease diagnostic blood test to urine.
This Viewpoint discusses 2 next-generation approaches to diagnosis and therapy that are either already clinically relevant or likely to be tested in central nervous system neurotropic viral infections in the near future.
This Viewpoint discusses the global effort to synchronize transition from trivalent to bivalent oral polio vaccine as a crucial component of the effort to eradicate polio.
A woman who had undergone an emergency craniotomy for brain decompression had purulent discharge from her right ear; imaging detected middle ear, mastoid, and infralabyrinthine involvement and meningitis and a large cerebellar lesion. What is your diagnosis?
This interval-cohort study aims to establish a more powerful and meaningful clinical trial method in sporadic Creutzfeldt-Jakob disease.