Explore the latest in adverse drug events, including postmarketing surveillance, risk mitigation, and the pharmacogenetics of safety.
This cohort study evaluates the association between use of nonsteroidal anti-inflammatory drugs and incident acute kidney injury and chronic kidney disease in US Army soldiers.
This systematic review and meta-analysis examines randomized clinical trials to assess the safety and efficacy of medications used for patients with gastrointestinal and pancreatic neuroendocrine tumors.
A 31-year-old woman with a history of Wolff-Parkinson-White disease and a recent stage II Hodgkin lymphoma diagnosis developed a pruritic rash within 24 hours of the first day of chemotherapy. What is your diagnosis?
This cohort study of Tennessee Medicaid enrollees from 1999 through 2014 investigates the risk of unexpected death among children and youths aged 5 through 24 years without psychosis who are new users of antipsychotic medications compared with new users of control medications.
This population-based study examines the occurrence of hip fractures in elderly individuals before and after initiation of antidepressant medications.
This secondary analysis of a randomized clinical trial evaluates whether fetal growth restriction is associated with the effects of repeated doses of antenatal betamethasone on neurocognitive function in a cohort of children followed up in midchildhood.
This study examines the FDA Adverse Event Reporting System and PubMed databases for cases of noninfectious pneumonia acquired after FDA approval of the drug ustekinumab.
This cohort study assesses self-reported quality of life among patients referred to oncodermatology clinics for pruritus associated with immunotherapy.
This case-control study examines the association between the use of dipeptidyl peptidase 4 inhibitors and the risk of developing bullous pemphigoid in patients with diabetes.
This case study investigates the possible association of tumor necrosis factor α inhibitor treatment with adverse ophthalmologic events, in this case blepharitis and ectropion.
An HIV-positive man in his 30s being treated with pembrolizumab for metastatic programmed cell death ligand 1–positive squamous non–small cell lung cancer presents with pruritic, mildly painful, hyperpigmented papules and plaques on both feet. What is your diagnosis?
This Viewpoint analyzes data on the thrombotic risk associated with cyclin-dependent kinase inhibitors and notes the need for additional research on the thrombotic risk of these drugs, the influence of combined drug therapy on thrombotic risk, and patient selection.
This cohort study compares the effectiveness and adverse effects of methotrexate in Chinese patients with psoriasis with and without psoriatic arthritis.
This study examines whether using aripiprazole for the first time or adding it to a treatment regimen lead to serious outcomes for patients with a history of taking antipsychotic medications.
This open cohort study derives prediction models to estimate the risk of psychiatric adverse effects from levetiracetam use in patients with epilepsy.
A 41-year-old woman with stage IIa melanoma of the upper thigh presented with diffuse erythematous induration of the upper thigh expanding to the lower left abdominal area and palpable subcutaneous nodules on the ipsilateral gluteal region and leg during nivolumab therapy. What is your diagnosis?
This JAMA Patient Page describes evaluation for and diagnosis of penicillin allergy.
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