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    Adverse Drug Events

    Explore the latest in adverse drug events, including postmarketing surveillance, risk mitigation, and the pharmacogenetics of safety.

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    • Epidemiology of Myocarditis and Pericarditis Following mRNA Vaccination by Vaccine Product, Schedule, and Interdose Interval Among Adolescents and Adults in Ontario, Canada
      JAMA Network Open
      Research
      June 24, 2022

      This cohort study estimates rates of myocarditis and pericarditis after receipt of an mRNA COVID-19 vaccine among individuals in Ontario, Canada, stratified by recipients’ age and sex and by the vaccine product, schedule, and interdose interval.

      Public Health Pharmacy and Clinical Pharmacology Adolescent Medicine Cardiology Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Myocarditis or Pericarditis Following mRNA COVID-19 Vaccination
      JAMA Network Open
      Opinion
      June 24, 2022
      Public Health Pharmacy and Clinical Pharmacology Adolescent Medicine Clinical Pharmacy and Pharmacology Pediatrics
      Full Text | pdf link PDF open access
    • Analysis of Thromboembolic and Thrombocytopenic Events After the AZD1222, BNT162b2, and MRNA-1273 COVID-19 Vaccines in 3 Nordic Countries
      JAMA Network Open
      Research
      June 14, 2022

      This study evaluates the association between the AZD1222, BNT162b2, and mRNA-1273 vaccines and subsequent thromboembolic and thrombocytopenic events between 3 Nordic countries.

      Public Health Pharmacy and Clinical Pharmacology Clinical Pharmacy and Pharmacology Hematology Neurology
      Full Text | pdf link PDF open access
    • Sudden-Onset Monocular Blurry Vision in a Young Woman
      JAMA Ophthalmology
      Case Report
      June 9, 2022

      A 32-year-old woman with fever, flulike symptoms, and altered mental status developed sudden-onset blurry vision in her right eye. Following intravenous antibiotics and antivirals, laboratory and imaging results were negative and her mental status improved but blurry vision persisted in the right eye. What would you do next?

      Targeted and Immune Cancer Therapy Oncology Ophthalmology Sarcomas Retinal Disorders
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Association of Driver Oncogene Variations With Outcomes in Patients With Locally Advanced Non–Small Cell Lung Cancer Treated With Chemoradiation and Consolidative Durvalumab
      JAMA Network Open
      Research
      June 6, 2022

      This cohort study compares outcomes of 104 patients with unresectable locally advanced non–small cell lung cancer with and without driver variations treated with the PACIFIC regimen.

      Oncology Genetics and Genomics Lung Cancer Cancer Genetics Targeted and Immune Cancer Therapy
      Full Text | pdf link PDF open access
    • Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis—Coordinating Research Priorities to Move the Field Forward
      JAMA Dermatology
      Opinion
      June 1, 2022

      This Viewpoint describes the successes and gaps in research and clinical care of Steven-Johnson syndrome and toxic epidermal necrolysis.

      Dermatology Cutaneous Drug Reactions Allergy and Clinical Immunology
      Full Text | pdf link PDF
    • Ominous Electrocardiographic Abnormalities in a Patient With Hepatocellular Carcinoma
      JAMA Internal Medicine
      Case Report
      June 1, 2022

      This case report describes the electrocardiogram findings of a patient with 1 week of progressive weakness, myalgia, dyspnea, and ptosis.

      Cardiology Clinical Pharmacy and Pharmacology Targeted and Immune Cancer Therapy Challenges in Clinical Electrocardiography Hepatobiliary Disease
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Chemotherapy-Induced Peripheral Neuropathy
      JAMA Internal Medicine
      Opinion
      May 31, 2022

      This Teachable Moment describes a man in his 70s with stage III colon cancer who presented with sensory symptoms after undergoing chemotherapy and was diagnosed with chemotherapy-induced peripheral neuropathy.

      Oncology Teachable Moment Neurology Neuropathy
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Appropriate Antibiotic Prescribing—The Safer and Less Expensive Choice
      JAMA Network Open
      Opinion
      May 26, 2022
      Pediatrics Antibiotic Use, Overuse, Resistance, Stewardship Health Care Economics, Insurance, Payment Health Care Quality Pharmacoeconomics
      Full Text | pdf link PDF open access
    • Association of Inappropriate Outpatient Pediatric Antibiotic Prescriptions With Adverse Drug Events and Health Care Expenditures
      JAMA Network Open
      Research
      May 26, 2022

      This cohort study evaluates the comparative safety and health care expenditures of inappropriate vs appropriate oral antibiotic prescriptions for common outpatient pediatric infections.

      Pediatrics Clinical Pharmacy and Pharmacology Infectious Diseases Health Care Safety Health Care Economics, Insurance, Payment
      Full Text | pdf link PDF open access
    • Association of Bullous Pemphigoid With Immune Checkpoint Inhibitor Therapy in Patients With Cancer: A Systematic Review
      JAMA Dermatology
      Review
      May 25, 2022

      This systematic review examines the risk factors, clinical presentation, diagnostic findings, treatments, and outcomes of immune checkpoint inhibitor–induced bullous pemphigoid.

      Dermatology Cutaneous Drug Reactions Clinical Pharmacy and Pharmacology Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Analysis of Neuropsychiatric Diagnoses After Montelukast Initiation
      JAMA Network Open
      Research
      May 24, 2022

      This cohort study investigates the association of montelukast treatment with adverse neuropsychiatric outcomes among patients with asthma or allergic rhinitis.

      Pulmonary Medicine Pharmacy and Clinical Pharmacology Asthma Clinical Pharmacy and Pharmacology Psychiatry and Behavioral Health
      Full Text | pdf link PDF open access
    • Blistering Lesions Associated With Loncastuximab Tesirine
      JAMA Dermatology
      Case Report
      May 18, 2022

      This case report describes 2 adult patients with diffuse large B-cell lymphoma who presented with small, tense blisters that appeared after receiving treatment with loncastuximab tesirine.

      Cutaneous Drug Reactions Clinical Pharmacy and Pharmacology Hematology Oncology Hematologic Cancer
      Full Text | pdf link PDF
    • Analysis of Stimulant Prescriptions and Drug-Related Poisoning Risk Among Persons Receiving Buprenorphine Treatment for Opioid Use Disorder
      JAMA Network Open
      Research
      May 11, 2022

      This cohort study with a case-crossover analytical design examines the associations between prescription stimulant use and drug-related poisonings and buprenorphine treatment retention among patients with opioid use disorder.

      Attention Deficit/Hyperactivity Disorders Clinical Pharmacy and Pharmacology Psychiatry and Behavioral Health Addiction Medicine Opioids
      Full Text | pdf link PDF open access
    • Stimulant Prescription Medications Among Persons Receiving Buprenorphine for Opioid Use Disorder With Prior Drug-Related Poisoning—Evidence of Net-Sum Gain
      JAMA Network Open
      Opinion
      May 11, 2022
      Attention Deficit/Hyperactivity Disorders Clinical Pharmacy and Pharmacology Psychiatry and Behavioral Health Addiction Medicine Opioids
      Full Text | pdf link PDF open access
    • Outcomes of Acitretin Treatment for Refractory Multikinase Inhibitor–Induced Hand-Foot Skin Reaction
      JAMA Dermatology
      Research
      May 11, 2022

      This cohort study assesses the outcomes of acitretin treatment for multikinase inhibitor–associated hand-foot skin reaction.

      Dermatology Cutaneous Drug Reactions Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF
    • Photodistributed Toxic Epidermal Necrolysis: Case Report and Review of Current Literature
      JAMA Dermatology
      Research
      May 4, 2022

      This case report describes a patient with photodistributed Stevens-Johnson syndrome and toxic epidermal necrolysis and highlights similarities to other cases reported in the literature.

      Dermatology Cutaneous Drug Reactions Clinical Pharmacy and Pharmacology Allergy and Clinical Immunology
      Full Text | pdf link PDF
    • Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials
      JAMA Internal Medicine
      Research
      May 1, 2022

      This systematic review and meta-analysis of 76 randomized clinical trials examines the effects of glucagon-like peptide-1 receptor agonist use on the risk of gallbladder and biliary diseases.

      Clinical Pharmacy and Pharmacology Hepatobiliary Disease Pharmacoepidemiology Gastroenterology and Hepatology Diabetes and Endocrinology
      Full Text | pdf link PDF
    • Glucagon-Like Peptide-1 Receptor Agonists—How Safe Are They?
      JAMA Internal Medicine
      Opinion
      May 1, 2022
      Clinical Pharmacy and Pharmacology Diabetes Pharmacoepidemiology Diabetes and Endocrinology
      Full Text | pdf link PDF
    • Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care
      JAMA Pediatrics
      Research
      May 1, 2022

      This pragmatic prospective implementation trial uses a rapid genotyping platform for the m.1555A>G variant to assess whether this technology could be implemented to avoid aminoglycoside-induced ototoxicity without disrupting normal clinical practice on neonatal intensive care units.

      Neonatology Pediatrics Pharmacogenetics Antibiotic Use, Overuse, Resistance, Stewardship Infectious Diseases
      Full Text | pdf link PDF open access
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