Explore the latest in adverse drug events from The JAMA Network, including postmarketing surveillance, risk mitigation, and the pharmacogenetics of safety.
This Viewpoint discusses the need to balance speed of approval and safety of drugs in the US Food and Drug Administration’s process of drug approval.
This Medical News article examines the use of stomach acid suppressors to treat mild gastric reflux in infants.
This population-based, case series study examines the incidence of suicide attempts during treatment with methylphenidate in patients with attention-deficit/hyperactivity disorder.
This systematic review and meta-analysis examines the responses of children and adolescents with common psychiatric disorders who receive selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, or placebo.
A 15-year-old boy presented to a hospital with pain and purpura of his left thigh after an intramuscular injection. What is your diagnosis?
This case series investigates whether low-dose naltrexone is an effective treatment for recalcitrant Hailey-Hailey disease.
This cohort study investigates the frequency, clinical spectrum, and optimum treatment approach to neurological complications associated with anti–PD-1 inhibitor use.
This cross-sectional analysis of trial documents submitted to regulators examines the degree to which the study purpose is explained to potential participants in randomized clinical trials of antibiotics.
This study characterizes purpuric skin eruptions caused by epidermal growth factor receptor inhibitors.
This case series describes alemtuzumab-induced neutropenia in 2 patients with multiple sclerosis.
This nonrandomized interventional cohort study investigates the safety and efficacy of cryolipolysis for reduction of lateral and central submental fat.
This Viewpoint questions the use of anthracyclines in the treatment of gastroesophageal cancers.
This cohort study describes the incidence of antibiotic-associated adverse drug events for adult inpatients receiving systemic antibiotic therapy.
This study examines adverse events for cosmetics in the FDA’s Center for Food Safety and Applied Nutrition’s Adverse Event Reporting System to inform future policymaking to protect consumers.
This JAMA Insights article explains the association between prescribing antibiotics based on patients’ outdated history of penicillin allergy and the risk of increased antimicrobial resistance.
This case series study characterizes the immunohistochemical phenotype of the infiltrate in histiocytoid Sweet syndrome and evaluates whether this variant of Sweet syndrome is more frequently associated with hematologic malignancies than classic Sweet syndrome.
This review examines the incidence, clinical presentations, and mechanisms of cardiovascular complications in patients with multiple myeloma.