Explore the latest in bleeding and transfusion, including trauma and resuscitation, transfusion thresholds and complications, and more.
This pharmacoepidemiology study examines the association between oral anticoagulants (warfarin, apixaban, dabigatran, and rivaroxaban), cotherapy with proton pump inhibitors (PPIs), and upper gastrointestinal (UGI) tract bleeding in Medicare beneficiaries.
This Teachable Moment describes the case of a 58-year-old man with bilateral knee osteoarthritis who presented to the emergency department with 1 week of dizziness and intermittent dark stools.
A 52-year-old woman with type 2 diabetes and a history of breast cancer presents with blurry vision in her right eye and signs of intraretinal fluid. What would you do next?
This secondary analysis of a randomized clinical trial assesses if different biomarkers provide information about the risk for all-cause and cause-specific mortality after acute coronary syndrome.
This exploratory analysis of 1690 patients enrolled in the Field Administration of Stroke Therapy-Magnesium Trial assesses the frequency, predictors, and outcomes of the neurological deterioration that occurs among patients during the ultra-early period after ischemic stroke or intracranial hemorrhage.
This randomized clinical trial evaluates the safety and efficacy of atrovastatin as a nonsurgical alternative for treating Chinese patients with chronic subdural hematoma.
A previously healthy man in his 50s presented with a 1-day history of sudden painful decreased vision in the right eye, with conjunctival injection, nongranulomatous keratic precipitates, optic nerve swelling, intraretinal hemorrhages, and perivascular sheathing. What would you do next?
A woman in her early 50s with a history of polycystic ovarian syndrome, diabetes, stroke, and coronary artery disease presented to the emergency department with 12 hours of sudden-onset, constant, right lower quadrant abdominal pain associated with vomiting and melena. What is your diagnosis?
This case-control genome-wide association study identifies single nucleotide polymorphisms (SNPs) associated with major bleeding in warfarin-treated patients of African descent.
This diagnostic study compares a rules-based natural language processing (NLP) model with a machine learning (ML) model to detect bleeding events among patients in an intensive care unit (ICU) using clinical notes.
This case series describes the multimodal imaging findings of radial hemorrhage in the outer plexiform layer of Henle, which may be a complication of macular telangiectasia type 2.
A man in his 70s presents with normal intraocular pressures, extraocular motility, and confrontational visual fields; facial plethora is evident and retinal examination of the left eye reveals 2 blot hemorrhages and dilatation of the retinal veins that were not present 1 year earlier. What would you do next?
This cohort study uses ACS-NSQUIP registry data to examine the association between perioperative red blood cell transfusions and postoperative venous thromboembolism within 30 days of surgery among North American patients undergoing surgery.
This randomized clinical trial evaluates the effectiveness of different instructional point-of-care interventions and in-person training for hemorrhage control and assesses skill retention 3 to 9 months after hemorrhage control training.
This review discusses the clinical manifestations and molecular basis of McLeod syndrome in comparison with other neuroacanthoscytosis syndromes, provides a comprehensive listing of alleles with involvement in McLeod syndrome, and discusses molecular tools to elucidate the genetic cause of the syndrome.
This commentary discusses a randomized clinical trial published in JAMA Surgery comparing the effects of point-of-care vs video instructions vs in-person training about tourniquet use on correct tourniquet application and skill retention 3 to 9 months after hemorrhage control training.
This Medical Letter review discusses the mechanism of action, adverse effects, and cost associated with coagulation factor Xa that was approved by the US Food and Drug Administration for reversal of the anticoagulant effect of the direct factor Xa inhibitors apixaban and rivaroxaban.
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