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    Connective Tissue Disease of the Skin

    Explore the latest in connective tissue disease of the skin, including advances in understanding its diagnosis and management.

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    • Tocilizumab for Corticosteroid-Refractory Immune Checkpoint Inhibitor–Induced Generalized Morphea
      JAMA Dermatology
      Case Report
      January 1, 2023

      This case report describes a 78-year old woman with a stage IIA BRAF wild-type melanoma on the left leg who experienced a grade 2 vitiligo, a marked skin thickening, and painful swelling of the limbs.

      Dermatology Cutaneous Drug Reactions Rheumatology Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF
    • Apremilast in Recalcitrant Cutaneous Dermatomyositis: A Nonrandomized Controlled Trial
      JAMA Dermatology
      Research
      December 1, 2022

      This nonrandomized controlled trial investigates the overall response rate associated with apremilast as an add-on therapy among patients with recalcitrant cutaneous dermatomyositis.

      Rheumatology Dermatology
      Full Text | pdf link PDF
    • Sarcoidosis of the Skin
      JAMA Dermatology
      Patient Information
      December 1, 2022

      This Patient Page describes the symptoms, diagnosis, and treatment of sarcoidosis of the skin.

      Dermatology Patient Information JAMA Dermatology Patient Information
      Full Text | pdf link PDF free
    • Treatment With Anifrolumab for Discoid Lupus Erythematosus
      JAMA Dermatology
      Case Report
      November 25, 2022

      This case report describes 2 women with severe and refractory discoid lupus erythematosus that was treated with anifrolumab.

      Dermatology
      Full Text | pdf link PDF
    • Incidence of Dermatomyositis in a Nationwide Cohort Study of US Veterans
      JAMA Dermatology
      Research
      November 1, 2022

      This cohort study evaluates the incidence of dermatomyositis and its trend over time in the US Department of Veterans Affairs health care system.

      Rheumatology Dermatology
      Full Text | pdf link PDF
    • Proton Pump Inhibitors Associated With Drug-Induced Lupus Erythematosus
      JAMA Dermatology
      Research
      October 1, 2022

      This descriptive case series investigates the potential association between the use of proton pump inhibitors and drug-induced lupus erythematosus in cases reported in 2 large pharmacovigilance databases.

      Dermatology Gastroenterology Gastroesophageal Reflux Gastroduodenal Ulcer Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Firm Red-Brown Plaques in a Patient With Systemic Scleroderma
      JAMA Dermatology
      Case Report
      September 1, 2022

      A man in his 60s with systemic sclerosis complicated by scleroderma kidney crisis, heart failure, interstitial lung disease, sclerodactyly, and Raynaud phenomenon presented with a pruritic rash. What is your diagnosis?

      Rheumatology Clinical Challenge Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • A Woman With Painful Digital Ulcers
      JAMA
      Case Report
      April 26, 2022

      A woman had 6 months of digital erythema and painful finger ulcers that had increased in number and become more painful in the past several weeks, along with erythematous and scaly papules and scale and fissures on the lateral aspect of several digits. She had normal strength throughout all muscle groups and a normal creatine kinase level. What is the diagnosis and what would you do next?

      Pulmonary Medicine Rheumatology Clinical Challenge Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Association of Treatment With Secukinumab With Exacerbation of Dermatomyositis in a Patient With Psoriasis
      JAMA Dermatology
      Case Report
      April 1, 2022

      This case report describes a woman in her 20s with a history of psoriasis and juvenile dermatomyositis who presented for management of worsening psoriasis at a time when her juvenile dermatomyositis had been in remission for several years.

      Dermatology Psoriasis Rheumatology Pediatrics
      Full Text | pdf link PDF
    • Lupus Pernio
      JAMA Dermatology
      Case Report
      April 1, 2022

      This case report describes violaceous papules on the nasal alae and medial periorbital skin, hypopigmented indurated plaques on the bilateral upper extremities and back, and verrucous plaques on the lower extremities and back.

      Dermatology Images in Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Clinically Amyopathic Juvenile Dermatomyositis
      JAMA Dermatology
      Case Report
      April 1, 2022

      This case report describes ragged cuticles; flat-topped pink papules overlying the bilateral metacarpophalangeal, proximal interphalangeal, and distal interphalangeal joints that were consistent with Gottron papules; and a spontaneous skin ulceration on the right knee.

      Rheumatology Images in Dermatology Pediatrics Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Generalized Micropapular Eruption in a Teenager
      JAMA Dermatology
      Case Report
      April 1, 2022

      A teenaged boy presented with a 1-year history of asymptomatic cutaneous lesions on the face that had spread to the trunk and extremities; he also had asthenia and mild intermittent arthralgias. What is your diagnosis?

      Dermatology Clinical Challenge Pediatrics Adolescent Medicine
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Lupus Miliaris Disseminatus Faciei
      JAMA Dermatology
      Case Report
      March 1, 2022

      This case report describes multiple small, symmetrical, reddish brown papules on the cheeks, nose, and eyelids.

      Images in Dermatology Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Risk-Based Screening for Cancer in Patients With Dermatomyositis: Toward a More Individualized Approach
      JAMA Dermatology
      Opinion
      March 1, 2022
      Cancer Screening, Prevention, Control Oncology Rheumatology Dermatology
      Full Text | pdf link PDF
    • Treatment With Mycophenolate Mofetil for Salt-and-Pepper Dyspigmentation Caused by Autoimmune Sclerosing Disease
      JAMA Dermatology
      Case Report
      March 1, 2022

      This case report describes 3 patients with systemic sclerosis or mixed connective tissue disease with scleroderma features who experienced salt-and-pepper dyspigmentation that responded to treatment with mycophenolate mofetil.

      Dermatology Rheumatology
      Full Text | pdf link PDF
    • Interventions for Cutaneous Disease in Systemic Lupus Erythematosus: Summary of a Cochrane Review
      JAMA Dermatology
      February 1, 2022

      This Clinical Evidence Synopsis presents key findings from a Cochrane review of interventions for cutaneous disease in systemic lupus erythematosus.

      Dermatology Rheumatology
      Full Text | pdf link PDF
    • Dermatomyositis With Carcinoma of Unknown Primary Disease in the Head and Neck Diagnosed by Muscle Biopsy During Neck Dissection
      JAMA Otolaryngology–Head & Neck Surgery
      Case Report
      February 1, 2022

      This case report describes a unique case of dermatomyositis in a patient with carcinoma of unknown primary cancer in the head and neck in which neck dissection was a preceding treatment.

      Oncology Surgery Surgical Oncology Rheumatology Dermatology
      Full Text | pdf link PDF has multimedia
    • Arc-Shaped Furrow on the Forehead Extending From Linear Alopecia on the Vertex
      JAMA Dermatology
      Case Report
      January 1, 2022

      A man in his 50s presented with a depressed skin groove on his forehead and linear hair loss. Examination revealed 2 long curved alopecic patches on the left side of the vertex and frontal scalp area extending to the left eyebrow. What is your diagnosis?

      Hair Disorders Clinical Challenge Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Erythematous Papules and Hemorrhagic Vesicles in a Woman With Arthralgias and Eye Pain
      JAMA
      Case Report
      December 14, 2021

      A 48-year-old woman with diet-controlled diabetes had extremity arthralgias, a purpuric rash and foot paresthesias, and eye pain and redness. Vital signs and results of laboratory testing including direct immunofluorescence were unremarkable; skin biopsy showed leukocytoclasia, erythrocytic extravasation, and fibrin in small blood vessel walls. What is the diagnosis and what would you do next?

      Dermatology Rheumatology Clinical Challenge Ophthalmology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Cutaneous Lupus Erythematosus of the Vulvar Skin
      JAMA Dermatology
      Case Report
      November 1, 2021

      This case report describes scarred erythematous patches on the labia majora, labia minora, and inguinal folds with no mucosal involvement.

      Images in Dermatology Dermatology
      Full Text | pdf link PDF
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