Intraocular Inflammation

A 28-year-old woman presented to the emergency department with a 5-day history of bilateral blurry vision, eye redness, discharge, photophobia, and pain. There were more than 20 cells per high-power field of 1 mm × 1 mm beam, with fibrin bilaterally and 2.5-mm hypopyon in the right eye and 2.7-mm hypopyon in the left eye. What would you do next?

This cohort study assesses the frequency of antidrug antibodies (ADAs) in patients with noninfectious uveitis receiving tumor necrosis factor α inhibitors and the association of ADAs with drug levels and clinical response in these patients.

A 59-year-old woman with a 5-year history of intermittent bilateral uveitis and scleritis presented with painful left uveitis and an episcleral nodule shown to be a uveal-episcleral lesion on ultrasound biomicroscopy. Biopsy of a nasal sinus mass 3 years earlier showed a histiocytic infiltrate with emperipolesis, consistent with Rosai-Dorfman-Destombes disease. What would you do next?

A man aged 55 years presented with worsening vision, photopsia, floaters, and eye redness, left eye greater than right. Dilated examination of the left eye revealed vitreous haze and cell, along with multifocal chorioretinal scars extending from the optic nerve to the macula. What is your diagnosis?

This case report describes the subretinal fibrosis and treatment of a patient diagnosed with Vogt-Koyanagi-Harada syndrome.

A 12-year-old girl with bilateral panuveitis presented for abnormal gait. Her subsequent workup revealed elevated inflammatory markers and subcentimeter chest and abdominal lymph nodes. What would you do next?

This cohort study assesses the real-world incidence of intraocular inflammation, including retinal vasculitis and/or retinal vascular occlusion for patients with neovascular age-related macular degeneration who underwent brolucizumab treatment.

This case report describes a teenage boy with left diffuse commotia retina, multiple choroidal ruptures, subfoveal hemorrhage, optic disc hemorrhage, and disseminated vitreous, retinal, and choroidal hemorrhage after a fireworks blast.

A 14-year-old boy had ocular and periocular pain with photophobia in his right eye. Routine blood tests showed a serum creatinine level of 1.57 mg/dL. What would you do next?

This survey study assesses the degree of uniformity in mapping of uveitis clinical concepts to ICD-10 codes across health care systems using the same electronic health record system.

A 34-year-old woman presents with blurred vision and photophobia after having cosmetic iris implants placed 6 months earlier. What would you do next?

A 50-year-old woman presents with left eye redness and headaches. Her best-corrected visual acuity is 20/20 OD and 20/25 OS. On examination, her left eye has 2 temporal scleral nodules with surrounding hyperemia and no scleromalacia. Laboratory test results show elevated levels of rheumatoid factor and C-reactive protein, and Lyme IgG, IgM, and reflex Western blot assays are positive for antibodies. Further testing shows she is negative for rheumatoid arthritis-associated nodular scleritis; however, new scleral thinning with persistence of the scleral nodules is noted. What would you do next?

This mendelian randomization and cohort study evaluates associations of tuberculosis with several noninfectious uveitis conditions, particularly Behçet disease, in cohorts in China and Japan, including a subgroup given T-SPOT.TB assays.

This case report describes a patient with coronavirus disease 2019 who experienced severe ocular neuropathy with panuveitis, resulting in permanent loss of visual acuity.

This cohort study uses ophthalmologic examination data from patients evaluated at Pointe-à-Pitre University Hospital to investigate the ocular manifestations of serologically confirmed systemic Zika virus infection.