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    Intraocular Inflammation

    Explore the latest in intraocular inflammation, including recent advances in the diagnosis and management of uveitis and chorioretinitis.

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    • Bilateral Hypopyon in a Young Woman
      JAMA Ophthalmology
      Case Report
      June 1, 2023

      A 28-year-old woman presented to the emergency department with a 5-day history of bilateral blurry vision, eye redness, discharge, photophobia, and pain. There were more than 20 cells per high-power field of 1 mm × 1 mm beam, with fibrin bilaterally and 2.5-mm hypopyon in the right eye and 2.7-mm hypopyon in the left eye. What would you do next?

      Hematology Oncology Ophthalmology Hematologic Cancer Leukemias
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Early vs Deferred Non–Messenger RNA COVID-19 Vaccination Among Chinese Patients With a History of Inactive Uveitis: A Randomized Clinical Trial
      JAMA Network Open
      Research
      February 14, 2023

      This randomized clinical trial compares recommendations for early and deferred non–messenger RNA COVID-19 vaccination with respect to ocular outcomes among patients with inactive uveitis.

      Ophthalmology Vaccination Coronavirus (COVID-19)
      Full Text | pdf link PDF open access
    • Antidrug Antibodies to Tumor Necrosis Factor α Inhibitors in Patients With Noninfectious Uveitis
      JAMA Ophthalmology
      Research
      February 1, 2023

      This cohort study assesses the frequency of antidrug antibodies (ADAs) in patients with noninfectious uveitis receiving tumor necrosis factor α inhibitors and the association of ADAs with drug levels and clinical response in these patients.

      Ophthalmology Rheumatology
      Full Text | pdf link PDF
    • Therapeutic Drug Monitoring in Noninfectious Uveitis
      JAMA Ophthalmology
      Opinion
      February 1, 2023
      Ophthalmology Rheumatology
      Full Text | pdf link PDF
    • Treatment-Refractory Nodular Scleritis
      JAMA Ophthalmology
      Case Report
      November 1, 2022

      A 59-year-old woman with a 5-year history of intermittent bilateral uveitis and scleritis presented with painful left uveitis and an episcleral nodule shown to be a uveal-episcleral lesion on ultrasound biomicroscopy. Biopsy of a nasal sinus mass 3 years earlier showed a histiocytic infiltrate with emperipolesis, consistent with Rosai-Dorfman-Destombes disease. What would you do next?

      Hematology Clinical Challenge Ophthalmology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • A Middle-aged Man With Macular Lesions and Vitritis
      JAMA Ophthalmology
      Case Report
      July 1, 2022

      A man aged 55 years presented with worsening vision, photopsia, floaters, and eye redness, left eye greater than right. Dilated examination of the left eye revealed vitreous haze and cell, along with multifocal chorioretinal scars extending from the optic nerve to the macula. What is your diagnosis?

      Infectious Diseases Macular Diseases Ophthalmology Tuberculosis Choroidal Disorders
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Treatment of Oral Erosive Lichen Planus With Upadacitinib
      JAMA Dermatology
      Case Report
      April 1, 2022

      This case report describes a 45-year-old woman who presented with painful oral erosions and chronic human leukocyte antigen B27–positive psoriatic peripheral arthritis with associated recurrent anterior uveitis.

      Oncology Otolaryngology Rheumatology Dermatology Psoriasis
      Full Text | pdf link PDF
    • Annular Streaklike Subretinal Fibrosis in Vogt-Koyanagi-Harada Syndrome
      JAMA Ophthalmology
      Case Report
      February 17, 2022

      This case report describes the subretinal fibrosis and treatment of a patient diagnosed with Vogt-Koyanagi-Harada syndrome.

      Infectious Diseases Neurology CNS Infections Ophthalmic Images Inflammatory CNS Disorders
      Full Text | pdf link PDF
    • Bilateral Panuveitis and Myeloradiculopathy in a 12-Year-Old Girl
      JAMA Ophthalmology
      Case Report
      February 1, 2022

      A 12-year-old girl with bilateral panuveitis presented for abnormal gait. Her subsequent workup revealed elevated inflammatory markers and subcentimeter chest and abdominal lymph nodes. What would you do next?

      Adolescent Medicine Neuro-ophthalmology Neurology Ophthalmology Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Safety Outcomes of Brolucizumab in Neovascular Age-Related Macular Degeneration: Results From the IRIS Registry and Komodo Healthcare Map
      JAMA Ophthalmology
      Research
      January 1, 2022

      This cohort study assesses the real-world incidence of intraocular inflammation, including retinal vasculitis and/or retinal vascular occlusion for patients with neovascular age-related macular degeneration who underwent brolucizumab treatment.

      Macular Diseases Ophthalmology Retinal Disorders Rheumatology
      Full Text | pdf link PDF open access
    • Risk Factors for Intraocular Inflammation After Brolucizumab Treatment
      JAMA Ophthalmology
      Opinion
      January 1, 2022
      Macular Diseases Ophthalmology Retinal Disorders
      Full Text | pdf link PDF
    • Firework-Related Chorioretinitis Sclopetaria
      JAMA Ophthalmology
      Case Report
      December 15, 2021

      This case report describes a teenage boy with left diffuse commotia retina, multiple choroidal ruptures, subfoveal hemorrhage, optic disc hemorrhage, and disseminated vitreous, retinal, and choroidal hemorrhage after a fireworks blast.

      Ophthalmology Ophthalmic Images Retinal Disorders Choroidal Disorders
      Full Text | pdf link PDF
    • A Boy With Anterior Uveitis and Optic Disc Swelling
      JAMA Ophthalmology
      Case Report
      December 1, 2021

      A 14-year-old boy had ocular and periocular pain with photophobia in his right eye. Routine blood tests showed a serum creatinine level of 1.57 mg/dL. What would you do next?

      Nephrology Pediatrics Clinical Challenge Ophthalmology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Assessing the Uniformity of Uveitis Clinical Concepts and Associated ICD-10 Codes Across Health Care Systems Sharing the Same Electronic Health Records System
      JAMA Ophthalmology
      Research
      August 1, 2021

      This survey study assesses the degree of uniformity in mapping of uveitis clinical concepts to ICD-10 codes across health care systems using the same electronic health record system.

      Ophthalmology Electronic Health Records
      Full Text | pdf link PDF free
    • Blurred Vision in a Young Woman With Cosmetic Iris Implants
      JAMA Ophthalmology
      Case Report
      August 1, 2021

      A 34-year-old woman presents with blurred vision and photophobia after having cosmetic iris implants placed 6 months earlier. What would you do next?

      Ophthalmology Cosmetic Medicine, Non-Surgical Clinical Challenge Glaucoma
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Progressive Scleral Thinning in a Middle-aged Woman
      JAMA Ophthalmology
      Case Report
      July 1, 2021

      A 50-year-old woman presents with left eye redness and headaches. Her best-corrected visual acuity is 20/20 OD and 20/25 OS. On examination, her left eye has 2 temporal scleral nodules with surrounding hyperemia and no scleromalacia. Laboratory test results show elevated levels of rheumatoid factor and C-reactive protein, and Lyme IgG, IgM, and reflex Western blot assays are positive for antibodies. Further testing shows she is negative for rheumatoid arthritis-associated nodular scleritis; however, new scleral thinning with persistence of the scleral nodules is noted. What would you do next?

      Ophthalmology Clinical Challenge Infectious Diseases
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Tuberculosis Exposure With Risk of Behçet Disease Among Patients With Uveitis
      JAMA Ophthalmology
      Research
      April 1, 2021

      This mendelian randomization and cohort study evaluates associations of tuberculosis with several noninfectious uveitis conditions, particularly Behçet disease, in cohorts in China and Japan, including a subgroup given T-SPOT.TB assays.

      Infectious Diseases Tuberculosis Rheumatology Ophthalmology
      Full Text | pdf link PDF free
    • Coronavirus Disease 2019–Associated Ocular Neuropathy With Panuveitis: A Case Report
      JAMA Ophthalmology
      Case Report
      February 1, 2021

      This case report describes a patient with coronavirus disease 2019 who experienced severe ocular neuropathy with panuveitis, resulting in permanent loss of visual acuity.

      Coronavirus (COVID-19) Neurology Neuromuscular Diseases Neuropathy Ophthalmology
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • Zika Virus and Anterior Uveitis—4 Years After the Pandemic
      JAMA Ophthalmology
      Opinion
      January 1, 2021
      Infectious Diseases Global Health Ophthalmology
      Full Text | pdf link PDF
    • Association of Anterior Uveitis With Acute Zika Virus Infection in Adults
      JAMA Ophthalmology
      Research
      January 1, 2021

      This cohort study uses ophthalmologic examination data from patients evaluated at Pointe-à-Pitre University Hospital to investigate the ocular manifestations of serologically confirmed systemic Zika virus infection.

      Infectious Diseases Global Health Ophthalmology
      Full Text | pdf link PDF free
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