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    Neuromyelitis Optica

    Explore the latest in neuromyelitis optica spectrum disorders, including recent advances in diagnostic criteria, management, and prevention.

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    • Rapid Immunodot AQP4 Assay for Neuromyelitis Optica Spectrum Disorder
      JAMA Neurology
      Research
      September 5, 2023

      This case-control study investigates whether a rapid enzyme immunodot assay is equivalent to the gold standard cell-based assay for detecting immunoglobulin G autoantibodies against aquaporin 4 (AQP4) in patients with neuromyelitis optica spectrum disorder (NMOSD).

      Demyelinating Disorders Neuro-ophthalmology Neurology Ophthalmology Pathology and Laboratory Medicine
      Full Text | pdf link PDF
    • Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination
      JAMA Neurology
      Research
      September 1, 2023

      This cross-sectional study examines laboratory and imaging data for patients with demyelinating central nervous system disease to investigate the frequency of MOG-IgA and associated clinical features.

      Neurology Radiology Neuroimaging Neuro-ophthalmology Ophthalmology
      Full Text | pdf link PDF open access
    • Analysis of Pregnancy-Related Attacks in Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis
      JAMA Network Open
      Research
      August 4, 2022

      This systematic review and meta-analysis assesses factors associated with pregnancy-related be increased in the postpartum period of neuromyelitis attacks, annualized relapse rate, and Expanded Disability Status Scale score in each phase of pregnancy among patients with NMOSD.

      Neurology Pregnancy Obstetrics Obstetrics and Gynecology Demyelinating Disorders
      Full Text | pdf link PDF open access
    • Livedo Reticularis—A Presenting Sign of Neuromyelitis Optica Spectrum Disorder
      JAMA Neurology
      Case Report
      August 1, 2022

      This case report describes a man aged 58 years who presented with intermittent chest pain, numbness and tingling of the upper extremities, and a violaceous, reticular rash on his lower extremities, abdomen, and flank.

      Dermatology Images in Neurology Demyelinating Disorders Neuro-ophthalmology Neurology
      Full Text | pdf link PDF
    • Frequency of New Silent MRI Lesions in Myelin Oligodendrocyte Glycoprotein Antibody Disease and Aquaporin-4 Antibody Neuromyelitis Optica Spectrum Disorder
      JAMA Network Open
      Research
      December 8, 2021

      This cohort study assesses the frequency and characteristics of new brain and spinal cord silent lesions on magnetic resonance imaging in seropositive patients with myelin oligodendrocyte glycoprotein antibody disease or aquaporin-4 antibody neuromyelitis optica spectrum disorder.

      Neurology Radiology Neuroimaging Neuro-ophthalmology Ophthalmology
      Full Text | pdf link PDF open access
    • Health Disparities, Inequities, and Social Determinants of Health in Multiple Sclerosis and Related Disorders in the US: A Review
      JAMA Neurology
      Review
      December 1, 2021

      This narrative review provides a contemporary synthesis of evidence examining health disparities, inequities, and social determinants of health in US Black and Hispanic or Latinx patients with multiple sclerosis, neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody disorders.

      Health Disparities Health Inequities Multiple Sclerosis Demyelinating Disorders Neurology
      Full Text | pdf link PDF
    • Sequential Bilateral Vision Loss in a Woman With Scalp Tenderness and Jaw Claudication
      JAMA Neurology
      Case Report
      July 1, 2021

      A 67-year-old woman with fibromyalgia presents with sequential bilateral vision loss; scalp tenderness; jaw claudication; neck, shoulder, and back pain; and recent weight loss. What is your diagnosis?

      Demyelinating Disorders Neurology Clinical Challenge Ophthalmology Rheumatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • MOG-IgG Among Participants in the Pediatric Optic Neuritis Prospective Outcomes Study
      JAMA Ophthalmology
      Research
      May 1, 2021

      This study examines the association of myelin oligodendrocyte glycoprotein immunoglobulin G–associated disorder with pediatric optic neuritis to guide prognosis and treatment.

      Demyelinating Disorders Neuro-ophthalmology Neurology Ophthalmology Pediatrics
      Full Text | pdf link PDF free
    • Biotinidase Deficiency as a Mimic of Neuromyelitis Optica Spectrum Disorder in Childhood
      JAMA Neurology
      Research
      January 1, 2021

      This study details a case of biotinidase deficiency mimicking neuromyelitis optica spectrum disorders and reviews prior cases of biotinidase deficiency that met Wingerchuck 2015 criteria for neuromyelitis optica spectrum disorder.

      Neuro-ophthalmology Neurology Ophthalmology Spinal Cord Disorders Demyelinating Disorders
      Full Text | pdf link PDF free
    • Application of 2015 Seronegative Neuromyelitis Optica Spectrum Disorder Diagnostic Criteria for Patients With Myelin Oligodendrocyte Glycoprotein IgG–Associated Disorders
      JAMA Neurology
      Research
      December 1, 2020

      This study evaluates the proportion of patients with myelin oligodendrocyte glycoprotein IgG–associated disorders who fulfill the seronegative neuromyelitis optica spectrum disorder criteria.

      Neuro-ophthalmology Neurology Ophthalmology Spinal Cord Disorders Demyelinating Disorders
      Full Text | pdf link PDF free
    • Long-term Outcomes in Patients With Myelin Oligodendrocyte Glycoprotein Immunoglobulin G–Associated Disorder
      JAMA Neurology
      Research
      December 1, 2020

      This cohort study reports outcomes of long-term follow-up in patients with myelin oligodendrocyte glycoprotein antibody–associated disorder.

      Pediatrics Ophthalmology Spinal Cord Disorders Demyelinating Disorders Neurology
      Full Text | pdf link PDF free
    • First Treatment for Rare Autoimmune Neuromyelitis
      JAMA
      News
      August 20, 2019
      Demyelinating Disorders Neurology Ophthalmology Neuro-ophthalmology
      Full Text | pdf link PDF
    • Anti–Myelin Oligodendrocyte Glycoprotein Antibody–Associated Central Nervous System Demyelination—A Novel Disease Entity?
      JAMA Neurology
      Opinion
      August 1, 2018

      This Viewpoint summarizes the current knowledge of the clinical, radiologic, and immunologic features of adult patients who are positive for anti–myelin oligodendrocyte glycoprotein and compares these individuals with patients with multiple sclerosis and patients with neuromyelitis optica.

      Demyelinating Disorders Neuro-ophthalmology Ophthalmology Spinal Cord Disorders Neurology
      Full Text | pdf link PDF
    • Disease Course and Treatment Responses in Children With Relapsing Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease
      JAMA Neurology
      Research
      April 1, 2018

      This multinational cohort study examines the clinical phenotypes, treatment responses, and outcomes of children with relapsing myelin oligodendrocyte glycoprotein antibody–associated disease.

      Pediatrics Multiple Sclerosis Neurology Ophthalmology Neuro-ophthalmology
      Full Text | pdf link PDF free
    • Valuable Insights Into Visual Neuroplasticity After Optic Neuritis
      JAMA Neurology
      Opinion
      March 1, 2018
      Neuro-ophthalmology Neurology Ophthalmology Multiple Sclerosis Demyelinating Disorders
      Full Text | pdf link PDF
    • Association of Visual Impairment in Neuromyelitis Optica Spectrum Disorder With Visual Network Reorganization
      JAMA Neurology
      Research
      March 1, 2018

      This cross-sectional study examines adaptive visual network connectivity changes in neuromyelitis optica spectrum disorder.

      Demyelinating Disorders Neuro-ophthalmology Neurology Spinal Cord Disorders Ophthalmology
      Full Text | pdf link PDF free
    • Safety and Efficacy of Bortezomib in Patients With Highly Relapsing Neuromyelitis Optica Spectrum Disorder
      JAMA Neurology
      Research
      August 1, 2017

      This study examines the safety and efficacy of bortezomib in patients with highly relapsing neuromyelitis optica spectrum disorder.

      Demyelinating Disorders Neuro-ophthalmology Neurology Ophthalmology Spinal Cord Disorders
      Full Text | pdf link PDF free
    • Association of Extension of Cervical Cord Lesion and Area Postrema Syndrome With Neuromyelitis Optica Spectrum Disorder
      JAMA Neurology
      Research
      March 1, 2017

      This study evaluates whether longitudinally extensive cervical cord lesions extending to or accompanied by area postrema/dorsal medulla lesions on magnetic resonance imaging are specific for neuromyelitis optica spectrum disorders.

      Demyelinating Disorders Neuro-ophthalmology Neurology Ophthalmology Spinal Cord Disorders
      Full Text | pdf link PDF free
    • Efficacy and Safety of Rituximab Therapy in Neuromyelitis Optica Spectrum Disorders: A Systematic Review and Meta-analysis
      JAMA Neurology
      Research
      November 1, 2016

      This systematic review and meta-analysis evaluates the efficacy and safety of rituximab therapy in neuromyelitis optica spectrum disorders, considering the potential predictive factors related to patient response to rituximab in this disease.

      Neuro-ophthalmology Neurology Ophthalmology Spinal Cord Disorders Demyelinating Disorders
      Full Text | pdf link PDF free
    • Rituximab Therapy in Neuromyelitis Optica: Moving Toward a Personalized Medicine Approach
      JAMA Neurology
      Opinion
      September 1, 2015
      Demyelinating Disorders Neuro-ophthalmology Neurology Ophthalmology Spinal Cord Disorders
      Full Text | pdf link PDF
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