Explore the latest in pharmacoepidemiology, including population studies of drug utilization and safety, comparative effectiveness research, and more.
This systematic review and meta-analysis examines randomized clinical trials (RCTs) of modern cancer drugs in the adjuvant setting to determine the incidence of severe adverse events reported in placebo groups.
This pharmacoepidemiology study examines the association between oral anticoagulants (warfarin, apixaban, dabigatran, and rivaroxaban), cotherapy with proton pump inhibitors (PPIs), and upper gastrointestinal (UGI) tract bleeding in Medicare beneficiaries.
This Viewpoint discusses obstacles that limit the use of biosimilar filgrastim in the United States compared with countries in the European Union and Japan and discusses strategies that might help biosimilar filgrastim use become more widespread.
This population-based case-control study investigates the association of prenatal exposure to medications that interfere with different neurotransmitter systems with the risk of autism spectrum disorders in offspring in a birth cohort of individuals with and without the disorder.
This study uses data from the Alberta Kidney Disease Network population database to evaluate the association of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use with posthospitalization outcomes in patients with acute kidney injury.
This retrospective observational analysis of health claims data compares the safety, effectiveness, and cost of biosimilar filgrastim and filgrastim.
This cohort study uses data from the Nurses’ Health Studies to evaluate associations between use of nonsteroidal anti-inflammatory drugs and risk of epithelial ovarian cancer.
This pooled analysis of the Nurses’ Health Study and the Health Professionals Follow-up Study examines the association between long-term use of aspirin and the development of hepatocellular carcinoma in adult men and women.
This pharmacoepidemiology study describes trends in first prescriptions for gabapentin and pregabalin in UK primary care practices and rates of these prescriptions for an off-label indication or with coprescription of opioids or benzodiazepines between 1993 and 2017.
This nationwide cohort study analyzes health register data from Norway to determine the incidence rate of atopic dermatitis among children younger than 6 years.
This study estimates the costs of pivotal clinical trials for all new therapeutic agents approved by the US Food and Drug Administration from 2015 to 2016 and examines how key features of the pivotal trials were associated with these costs.
This cohort study compares the risk for venous thromboembolism among women who use extended cyclic and continuous combined oral contraceptives (COCs) with that among women who use traditional cyclic COCs, while holding the progestogen type constant.
This cohort study uses drug benefit claims data in Ontario, Canada, to estimate the frequency of and variation in prescription nonsteroidal anti-inflammatory drug (NSAID) use among high-risk patients with musculoskeletal disorders and hypertension, heart failure, or chronic kidney disease (CKD) and identifies characteristics associated with prescription NSAID use and its potential association with short-term, safety-related outcomes.
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