Schizophrenia Spectrum and Other Psychotic Disorders

This case-control study models the processes that explain spatial patterns of gray matter volume loss in different stages of psychotic illness and assesses whether certain brain regions act as putative epicenters from which volume loss spreads.

This case-control study examines whether patients diagnosed with psychotic disorder or nonpsychotic bipolar disorder differed from a control group in their deprivation and population density trajectories.

This case-control study examines mRNA levels of somatostatin (SST) in the dorsolateral prefrontal cortex of postmortem brain specimens from patients with schizophrenia, bipolar disorder, and major depression disorder to assess whether alterations in SST levels are diagnosis specific and associated with cognitive dysfunction.

This cohort study examines the association between area-level ethnic density during childhood, perceived discrimination, and psychosis risk outcomes among ethnoracial minoritized individuals at clinical high risk for psychosis.

This cohort study uses patient data from the Medicaid and Children’s Health Insurance Program to investigate if antipsychotic treatment of children and young adults without severe somatic illness or psychosis is associated with increased risk of death.

This cross-sectional study evaluates findings from neuromelanin-sensitive magnetic resonance imaging, a proxy measure of dopamine function, to determine the association between contrast and psychosis severity in antipsychotic-free individuals in the psychosis spectrum and evaluate its predictive ability.

This systematic review and meta-analysis evaluates the prevalence of and factors associated with sexual dysfunction in individuals with schizophrenia-spectrum disorders.

This cohort study examines the risk of developing schizophrenia spectrum disorder following an emergency department (ED) visit caused by substance use with and without psychosis.

This case-control study assesses the association of brain morphometric changes that deviate from the normative range and with positive symptoms, cognition, and conversion to a psychotic disorder among individuals at high risk for psychosis.

This systematic review and meta-analysis examines data from studies of patients with first-episode psychosis to estimate the prevalence of clinically relevant neuroradiological abnormalities detected using magnetic resonance imaging.

This cross-sectional study analyzes spectroscopy data for long-term, never-medicated patients with schizophrenia to examine their levels of γ-aminobutyric acid (GABA) compared with those of healthy controls.

This prognostic study evaluates the improvement in performance of prediction models and elucidates dynamic clinical profiles using joint modeling to predict conversion to psychosis and symptom remission.

This systematic review and meta-analysis investigates the momentary emotional experience of people with schizophrenia and those at risk for psychosis compared with that of healthy individuals.