Explore the latest in schizophrenia and other psychotic disorders, including advances in understanding their neurophysiology and treatment.
This case-control study models the processes that explain spatial patterns of gray matter volume loss in different stages of psychotic illness and assesses whether certain brain regions act as putative epicenters from which volume loss spreads.
This case-control study examines whether patients diagnosed with psychotic disorder or nonpsychotic bipolar disorder differed from a control group in their deprivation and population density trajectories.
This case-control study examines mRNA levels of somatostatin (SST) in the dorsolateral prefrontal cortex of postmortem brain specimens from patients with schizophrenia, bipolar disorder, and major depression disorder to assess whether alterations in SST levels are diagnosis specific and associated with cognitive dysfunction.
This cohort study examines the association between area-level ethnic density during childhood, perceived discrimination, and psychosis risk outcomes among ethnoracial minoritized individuals at clinical high risk for psychosis.
This cohort study evaluates the association between psychiatric comorbidities and schizophrenia in children and adolescents with attention-deficit/hyperactivity disorder.
This case-control study examines the association between schizophrenia diagnosis, mammography rate, and physician reimbursement structures in Ontario, Canada.
This cohort study uses patient data from the Medicaid and Children’s Health Insurance Program to investigate if antipsychotic treatment of children and young adults without severe somatic illness or psychosis is associated with increased risk of death.
This cross-sectional study evaluates findings from neuromelanin-sensitive magnetic resonance imaging, a proxy measure of dopamine function, to determine the association between contrast and psychosis severity in antipsychotic-free individuals in the psychosis spectrum and evaluate its predictive ability.
This systematic review and meta-analysis evaluates the prevalence of and factors associated with sexual dysfunction in individuals with schizophrenia-spectrum disorders.
This cohort study examines the risk of developing schizophrenia spectrum disorder following an emergency department (ED) visit caused by substance use with and without psychosis.
This cohort study examines the use of telemental health services by Medicare beneficiaries with schizophrenia or bipolar I disorder, and whether outcomes differ according to a practice’s extent of telemedicine use.
This case-control study assesses the association of brain morphometric changes that deviate from the normative range and with positive symptoms, cognition, and conversion to a psychotic disorder among individuals at high risk for psychosis.
This review discusses current evidence regarding the diagnosis and treatment of bipolar disorder, including differential diagnoses, treatment of mania and depressive episodes, and maintenance treatment.
This randomized clinical trial evaluates the clinical effectiveness of multigenetic pharmacogenomics–guided treatment in schizophrenia among Han men in China.
This cohort study investigates if second-generation, nonrefugee, and refugee migrants in Sweden and Denmark experience more days hospitalized for nonaffective psychotic disorders during the first 5 years of illness than their native-born peers.
This systematic review and meta-analysis examines data from studies of patients with first-episode psychosis to estimate the prevalence of clinically relevant neuroradiological abnormalities detected using magnetic resonance imaging.
This cross-sectional study analyzes spectroscopy data for long-term, never-medicated patients with schizophrenia to examine their levels of γ-aminobutyric acid (GABA) compared with those of healthy controls.
This prognostic study evaluates the improvement in performance of prediction models and elucidates dynamic clinical profiles using joint modeling to predict conversion to psychosis and symptom remission.
This systematic review and meta-analysis investigates the momentary emotional experience of people with schizophrenia and those at risk for psychosis compared with that of healthy individuals.
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