Explore the latest in schizophrenia and other psychotic disorders, including advances in understanding their neurophysiology and treatment.
This follow-up study of a randomized clinical trial examines a cohort of patients who had participated in the trial 10 years ago to establish what factors were associated with successful discontinuation of antipsychotic medication regimens.
This cohort study of Tennessee Medicaid enrollees from 1999 through 2014 investigates the risk of unexpected death among children and youths aged 5 through 24 years without psychosis who are new users of antipsychotic medications compared with new users of control medications.
A college student presents to a psychosis early-detection clinic with declined functioning and social withdrawal. What would you do next?
This editorial comments on recent data that show a mortality gap between individuals with and without schizophrenia, with changes in the disparity as the amount of medical care given increases.
This cross-sectional study used confirmatory factor analysis to evaluate the fit of 4 models regarding the latent structure of negative symptoms using confirmatory factor analysis in a population of outpatients with schizophrenia.
This naturalistic functional magnetic resonance imaging study examines the association of age at onset and longitudinal course of prefrontal activity in youths with early-onset schizophrenia compared with age-matched healthy control individuals.
This study uses the Danish nationwide health care registries to investigate the association of secondary preventive cardiovascular treatment with all-cause mortality after myocardial infarction in patients with schizophrenia compared with those without schizophrenia.
This randomized clinical trial examines genes and gene sets using exome sequencing technology to determine the genetic mechanism behind the responses to antipsychotic drugs prescribed to patients with schizophrenia.
This article describes the development of categories of mental illness by Emil Kraepelin in the second through sixth editions of his textbook Psychiatrie: Ein Lehrbuch für Studierende und Ärzte.
This Viewpoint articulates the need for expanded epidemiological and anthropological research into the risk of psychotic disorders associated with urban living.
This nested case-control study evaluates whether the consultation patterns for a prespecified set of symptoms can be used to identify patients attending primary care who later developed a psychotic illness.
This systematic review and meta-analysis examines longitudinal studies on cohorts of individuals with psychotic experiences to determine their likelihood of suicidal ideation, suicide attempts, and suicide death.
This population-based cohort study investigates whether the type, frequency, and severity of trauma encountered during childhood is associated with an increase in the likelihood of hallucinations, delusions, thought interference, and other psychotic experiences in young adulthood.
This cross-sectional study investigates whether increased hippocampal glutamate levels are associated with adverse clinical outcomes in individuals at clinical high risk for psychosis compared with healthy control individuals, between clinical high-risk individuals who develop and do not develop psychosis, and between individuals with good and poor outcomes.
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