Explore the latest in schizophrenia and other psychotic disorders, including advances in understanding their neurophysiology and treatment.
This national cohort study examines the use of polypharmacy vs monotherapy as maintenance treatment among adult patients with schizophrenia who have been rehospitalized for psychiatric treatment in Finland.
This cohort study uses US national Medicaid data to compare the effectiveness of different psychotropic medication strategies (antidepressant, benzodiazepine, mood stabilizer, or another antipsychotic) for adult patients with schizophrenia who are receiving antipsychotic treatment.
This follow-up study of a randomized clinical trial examines a cohort of patients who had participated in the trial 10 years ago to establish what factors were associated with successful discontinuation of antipsychotic medication regimens.
This cross-sectional study investigates whether increased hippocampal glutamate levels are associated with adverse clinical outcomes in individuals at clinical high risk for psychosis compared with healthy control individuals, between clinical high-risk individuals who develop and do not develop psychosis, and between individuals with good and poor outcomes.
This cohort study of Tennessee Medicaid enrollees from 1999 through 2014 investigates the risk of unexpected death among children and youths aged 5 through 24 years without psychosis who are new users of antipsychotic medications compared with new users of control medications.
This systematic review and meta-analysis examines longitudinal studies on cohorts of individuals with psychotic experiences to determine their likelihood of suicidal ideation, suicide attempts, and suicide death.
This cohort study explores the association of polygenic risk scores for major depression, bipolar disorder, and schizophrenia with the risk for depression in the Danish population.
This study examines whether using aripiprazole for the first time or adding it to a treatment regimen lead to serious outcomes for patients with a history of taking antipsychotic medications.
This imaging genetics study examines genetic variants associated with adolescent brain structure and explores the psychopathologic relevance of such associations in the development of schizophrenia.
This case-control study investigates neural responsivity to food cues in patients with first-episode psychosis without the confounds of antipsychotic medication or illness chronicity.
This cross-sectional study evaluates whether 7-T magnetic resonance spectroscopy is a useful tool for assessing brain metabolite levels in regions salient to psychosis, and explores the association exists between regional metabolite levels and neuropsychological test performance among healthy participants and patients with first-episode psychosis.
This series of within-individual cohort studies assesses whether hydroxylmethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors, L-type calcium channel antagonists, and biguanides are associated with reduced rates of psychiatric hospitalization and self-harm in individuals with serious mental illness.
This cross-sectional study uses data from the Human Connectome Project and the Australian Twin Registry collected from twin and nontwin sibling pairs to investigate genetic and environmental factors in psychotic-like experiences associated with cannabis use.
This cohort study examines whether a history of pre-onset subthreshold psychotic symptoms is associated with differential 1-year treatment outcomes in an early intervention service for patients with a first episode of psychosis.
This population-based cohort study investigates whether the type, frequency, and severity of trauma encountered during childhood is associated with an increase in the likelihood of hallucinations, delusions, thought interference, and other psychotic experiences in young adulthood.
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