Explore the latest in anticoagulation, including dosing, safety, and reversal of newer oral agents, periprocedural management, and more.
This Clinical Evidence Synopsis summarizes a Cochrane review of randomized trials comparing the effects of treatment of lower extremity superficial thrombophlebitis on venous thromboembolism and major bleeding.
This Medical News article discusses the top-viewed articles published in the JAMA family of journals over the past year.
This pharmacoepidemiology study examines the association between oral anticoagulants (warfarin, apixaban, dabigatran, and rivaroxaban), cotherapy with proton pump inhibitors (PPIs), and upper gastrointestinal (UGI) tract bleeding in Medicare beneficiaries.
This editorial comments on recent data that show a mortality gap between individuals with and without schizophrenia, with changes in the disparity as the amount of medical care given increases.
This study uses the Danish nationwide health care registries to investigate the association of secondary preventive cardiovascular treatment with all-cause mortality after myocardial infarction in patients with schizophrenia compared with those without schizophrenia.
This systematic review and meta-analysis of randomized clinical trials assesses the risk of intracranial hemorrhage with non–vitamin K antagonist oral anticoagulant use compared with aspirin use.
This cohort study uses data from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II to assess racial/ethnic differences in the use of oral anticoagulants by patients with atrial fibrillation.
This meta-analysis compares the efficacy and safety of drug-eluting stents optimized for biocompatibility vs bare-metal stents with a single month of dual antiplatelet therapy.
This case-control genome-wide association study identifies single nucleotide polymorphisms (SNPs) associated with major bleeding in warfarin-treated patients of African descent.
This cohort study examines whether aspirin as a single agent is inferior to other anticoagulation agents for reducing the risk of venous thromboembolism or major bleeding events after unilateral primary total knee arthroplasty.
This Medical Letter review summarizes approved indications, doses, adverse effects, and costs of warfarin and newer oral anticoagulants used to treat venous thromboembolism.
This narrative review summarizes advances in diagnosis and treatment of venous thromboembolism (VTE), including use of age-adjusted D-dimer levels and rule-out criteria (PERC) to exclude the diagnosis, use of newer oral anticoagulants (NOACs) as treatment, and indications for thrombolysis.
A 74-year-old man taking rivaroxaban for atrial fibrillation developed a subdural hematoma and had an elevated prothrombin time (PT) with normal activated partial thromboplastin time (aPTT) and platelets prior to planned surgical evacuation. How do you interpret the results?
This comparative effectiveness analysis assesses the efficacy and safety of oral anticoagulants dabigatran, rivaroxaban, and warfarin in elderly Medicare beneficiaries with atrial fibrillation (AF) and multiple chronic conditions.
This cohort study uses Taiwan National Health Insurance database data to evaluate the incidence of ischemic stroke, hospitalization for heart failure, and all-cause mortality among patients with atrial fibrillation and atrial flutter stratified by CHA2DS2-VASc score.
This Medical Letter review discusses the mechanism of action, adverse effects, and cost associated with coagulation factor Xa that was approved by the US Food and Drug Administration for reversal of the anticoagulant effect of the direct factor Xa inhibitors apixaban and rivaroxaban.
This comparative effectiveness cohort study explores the association of inferior vena cava filter placement with 30-day mortality in patients with venous thromboembolic disease and a contraindication to anticoagulation.
This randomized trial compares the effects of intravenous alteplase vs oral aspirin treatment on functional outcomes in patients with minor nondisabling acute ischemic stroke.
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