Explore the latest in gastroenterology and hepatology, including recent advances in treatment of viral hepatitis and of GI and pancreatic cancers.
A 55-year-old man with several weeks of malaise, a 6.8-kg weight loss, a CT scan with multifocal liver masses and elevated alkaline phosphatase, ALT, and AFP levels had a heterogeneously enhancing pancreatic-tail mass on triple-phase CT. What would you do next?
This phase 2, multi-institutional clinical trial assesses whether patients with resected primary gastrointestinal stromal tumor receiving 5 years of adjuvant imatinib mesylate therapy have improved recurrence-free survival and overall survival compared with patients receiving a shorter duration of therapy in previous studies.
This survey study assesses patient attitudes and preferences about cessation of low-value colorectal cancer screening and their overall comfort using age, life expectancy calculators, and colorectal cancer risk calculators in helping make individualized screening decisions.
This JAMA Patient Page describes recent advancements in hepatitis C treatment.
This pharmacoepidemiology study examines the association between oral anticoagulants (warfarin, apixaban, dabigatran, and rivaroxaban), cotherapy with proton pump inhibitors (PPIs), and upper gastrointestinal (UGI) tract bleeding in Medicare beneficiaries.
This systematic review and meta-analysis examines interventions used to increase the rates of colorectal cancer screening tests.
This study examines the prevalence of conflicts of interest among authors of clinical practice guidelines and failure to accurately report financial relationships among authors and industry.
This Teachable Moment describes the case of a 58-year-old man with bilateral knee osteoarthritis who presented to the emergency department with 1 week of dizziness and intermittent dark stools.
This systematic review and meta-analysis of 9 studies comprising more than 7 million patients examines the association between psoriasis and inflammatory bowel disease.
This analysis of genomic data from The Cancer Genome Atlas and an Asian cohort investigates associations between MUC16 mutation, tumor mutation load, and survival in patients with gastric cancer.
This single-arm, 2-stage, phase 2 clinical trial assesses the safety and efficacy of intravenous gemcitabine plus nanoparticle albumin-bound–paclitaxel for treatment of adults with advanced cholangiocarcinoma.
This pooled analysis of the Nurses’ Health Study and the Health Professionals Follow-up Study examines the association between long-term use of aspirin and the development of hepatocellular carcinoma in adult men and women.
This Markov model study assesses the cost-effectiveness of capecitabine and bevacizumab maintenance therapy after induction chemotherapy for treatment of metastatic colorectal cancer.
This JAMA Clinical Guidelines Synopsis summarizes the 2017 practice guidance from the American Association for the Study of Liver Diseases on diagnosis and management of nonalcoholic fatty liver disease.
This Clinical Update discusses the risks and benefits of nonantibiotic medical, minimally invasive, and open surgical management for acute diverticulitis of various severities.
This study investigates the association of timing of colostomy reversal after diverticulitis with operative outcomes and patient characteristics using data from the Healthcare Cost and Utilization Project State Inpatient Databases.
This multicenter, phase 2, single-arm trial assesses the activity of cetuximab plus irinotecan as third-line treatment for patients with RAS and BRAF wild-type metastatic colorectal cancer who were initially sensitive to and then resistant to first-line irinotecan- and cetuximab-based therapy.
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