Explore the latest in pathology and laboratory medicine, including AI applications to biopsy readings, diagnostic test interpretation, and more.
A 5-year-old girl with a family history of cystic fibrosis presented with constipation, poor weight gain, and a BMI below the third percentile. Three sweat chloride tests were indeterminate, a CFTR analysis panel was negative, and whole-genome sequence analysis revealed 1 cystic fibrosis–causing mutation. What would you do next?
A 54-year-old man who had undergone Roux-en-Y gastric bypass 12 years ago presented for evaluation of new-onset pancytopenia. Histopathologic examination of bone marrow aspirate showed ringed sideroblasts and vacuolized erythroid and granulocytic precursors. What is the diagnosis and what would you do next?
This prospective cohort study evaluates the 5-year risk of cervical precancer following p16/ki-67 dual-stain triage of HPV-positive women.
This study uses Canadian administrative health databases to estimate gestational age–specific serum creatinine levels before, during, and after pregnancy among women without antecedent kidney disease.
This study provides longitudinal clinical disease-course data and neuropathologic association for newly proposed Parkinson disease subtypes.
This case series study examines whether the ability to achieve a prosthesis-free airway in adults after open airway reconstruction is associated with red blood cell distribution width at the time of surgery.
This cross-sectional study examines gender equity in the presidential leadership of medical specialty societies over a 10-year period.
This study investigates the utility of reinterpreting the genomic test results of pediatric patients who previously underwent genomic epilepsy testing.
This narrative review describes the evidence for propagation of distinct tau strains in Alzheimer disease and mechanistic insights into cell-to-cell transmission of pathological tau in multiple neurodegenerative diseases, including Alzheimer disease, progressive supranuclear palsy, corticobasal degeneration, and Pick disease.
This case study investigates the presence of the GNAQ R183Q mutation in the choroidal vessels of a patient with Sturge-Weber syndrome.
A 68-year-old woman with chronic lymphocytic leukemia (CLL) presents with dyspnea on exertion, conjunctival pallor and scleral icterus, and moderate anemia with elevated reticulocytes and LDH and a 3+ anti-IgG direct antiglobulin test (DAT). How do you interpret the results?
This cohort study of patients in 4 European countries and the United States with resected pancreatic ductal adenocarcinoma assesses the validity of the eighth edition of the American Joint Committee on Cancer TNM staging system compared with the seventh edition.
A white woman in her 70s with Alzheimer disease presented with a high hemoglobin level and red blood cell count as well as erythematous macular eruption over the trunk and limbs. What is your diagnosis?
This cohort study examines the prevalence of benign pathologic findings among adults after partial nephrectomy and potential risk factors associated with this prevelence.
This multicenter cohort study examines the outcomes and risk for the development of subsequent cutaneous melanoma in moderately dysplastic nevi excisionally biopsied without residual clinical pigmentation but with positive histologic margins, observed for 3 years or more.
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