Explore JAMA Network Open’s collection on clinical pharmacy and pharmacology, including topics in drug safety and development, pharmacogenetics, and more.
This cohort study uses national longitudinal data from the Social Insurance Institution of Finland to investigate the incidence of long-term use of benzodiazepines and related drugs among new users and factors associated with development of long-term use.
This cross-sectional study evaluates the association of adding 1000-mg acetaminophen tablets to the Swiss market with utilization and poisonings.
This cohort study analyzes the preoperative use of benzodiazepines compared with long-term postoperative use of opioids and association with health care costs.
This secondary analysis of the AVANT trial explores the efficacy of adjuvant bevacizumab combined with oxaliplatin-based chemotherapy and disease-free survival (DFS) rates in patients with high-risk, stage II colon cancer.
This cross-sectional study assesses drug coverage, formulary restrictions, median retail prices, and annual out-of-pocket costs associated with commonly used insulin products across Medicare Part D plans.
This randomized clinical trial examines whether 6-month interventions involving different financial incentives to encourage statin adherence reduce low-density lipoprotein cholesterol levels from baseline to 12 months.
This cohort study compares definitive therapy with oral β-lactam antibiotics vs fluoroquinolones or trimethoprim-sulfamethoxazole after 1 to 5 days of parenteral antibiotics for Enterobacterales bacteremia from a suspected urine source.
This randomized clinical trial assesses the efficacy and toxicity of radiotherapy plus icotinib compared with radiotherapy alone in older patients with unresectable esophageal squamous cell carcinoma (ESCC) in China.
This cohort study examines the association of integrated specialty pharmacy use among members of a university hospital accountable care organization (ACO) with total medical expenditure.
This cohort study assesses national trends and geographic variations in use of opioids and prescription nonsteroidal anti-inflammatory drugs (NSAIDs) in Medicare patients aged 65 years or older with and without chronic kidney disease in the US (2006-2015) and examines associations between use of opioids and patient outcomes.
This cohort study compares the effectiveness of generic vs brand-name levothyroxine in achieving and maintaining normal thyrotropin levels among new users.
This cross-sectional study evaluates opioid prescribing patterns from 2009 to 2018 in a network of community health centers that frequently treat low-income patients in the US.
This observational cohort study compares the odds of cardiac events among new users of azithromycin relative to new users of amoxicillin using real-world data.
This quality improvement study examines quality testing of prescription pharmaceutical products that are manufactured in various regions of the world and marketed in the US.
This cross-sectional study evaluates the pattern of aspirin use and statin use and adherence in US veterans with premature atherosclerotic cardiovascular disease.
This cross-sectional study describes key attributes of sole-source, off-patent, off-exclusivity drugs; characterizes the prevalence of price increases; and identifies attributes associated with price increases.
This randomized clinical trial compares treatment with candesartan vs lisinopril among adults with hypertension and mild cognitive impairment.
This statewide cohort study of more than 1.5 million person-years uses a comparative interrupted time series analysis to assess whether implementing an incentive metric is associated with effective contraceptive use among women enrolled in the Oregon Medicaid program.
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