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    Pharmacy and Clinical Pharmacology

    Explore JAMA Network Open’s collection on clinical pharmacy and pharmacology, including topics in drug safety and development, pharmacogenetics, and more.

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    • Expectations and Prior Experiences Associated With Adverse Effects of COVID-19 Vaccination
      JAMA Network Open
      Research
      March 27, 2023

      This cohort study investigates whether positive and negative expectations are associated with systemic adverse effects among adults receiving their second dose of COVID-19 vaccines.

      Infectious Diseases Vaccination Coronavirus (COVID-19) Clinical Pharmacy and Pharmacology Adverse Drug Events
      Full Text | pdf link PDF open access
    • Family Conferences to Facilitate Deprescribing in Older Outpatients With Frailty and With Polypharmacy: The COFRAIL Cluster Randomized Trial
      JAMA Network Open
      Research
      March 27, 2023

      This cluster randomized trial evaluates the effects of general practitioner–led family conferences on deprescribing and hospitalizations in community-dwelling older adults with frailty.

      Geriatrics Shared Decision Making and Communication Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Association of Antibiotic Receipt With Survival Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Receiving Chemotherapy
      JAMA Network Open
      Research
      March 23, 2023

      This cohort study examines survival among patients receiving antibiotic therapy concurrent with chemotherapy with gemcitabine or fluorouracil for metastatic pancreatic ductal adenocarcinoma.

      Oncology Pharmacoepidemiology Antibiotic Use, Overuse, Resistance, Stewardship Infectious Diseases Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Factors Associated With Public Trust in Pharmaceutical Manufacturers
      JAMA Network Open
      Research
      March 14, 2023

      This cross-sectional study examines how key demographic and predisposing factors are associated with consumer trust in pharmaceutical manufacturers.

      Public Health Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Evaluation of Health-Related Values and Preferences of Adults Who Were Preterm Infants and Parents of Preterm Infants Concerning Use of Prophylactic Cyclooxygenase Inhibitor Drugs
      JAMA Network Open
      Research
      March 9, 2023

      This cross-sectional study explores the health-related values and preferences of adults who had been preterm infants and parents of preterm infants concerning the use of cyclo-oxygenase inhibitors in preterm infants to prevent patent ductus arteriosus–related morbidity and mortality.

      Pediatrics Surgery Clinical Pharmacy and Pharmacology Neonatology Antenatal Exposures and Child Outcomes
      Full Text | pdf link PDF open access
    • Use of Leukotriene-Receptor Antagonists During Pregnancy and Risk of Neuropsychiatric Events in Offspring
      JAMA Network Open
      Research
      March 7, 2023

      This cohort study examines the association of the use of leukotriene-receptor antagonists during pregnancy with the risk of neuropsychiatric events in offspring.

      Pediatrics Antenatal Exposures and Child Outcomes Women's Health Clinical Pharmacy and Pharmacology Obstetrics and Gynecology
      Full Text | pdf link PDF open access
    • Assessment of Sex Disparities in Nonacceptance of Statin Therapy and Low-Density Lipoprotein Cholesterol Levels Among Patients at High Cardiovascular Risk
      JAMA Network Open
      Research
      February 28, 2023

      This cohort study assesses sex disparities in nonacceptance of statin therapy and assess their association with low-density lipoprotein (LDL) cholesterol control.

      Cardiology Clinical Pharmacy and Pharmacology Health Disparities Dyslipidemia Shared Decision Making and Communication
      Full Text | pdf link PDF open access
    • Risk Prediction Models for Cardiotoxicity of Chemotherapy Among Patients With Breast Cancer: A Systematic Review
      JAMA Network Open
      Research
      February 23, 2023

      This systematic review evaluates risk prediction models of cardiotoxicity for patients with breast cancer.

      Oncology Adverse Drug Events Women's Health Breast Cancer Cardiology
      Full Text | pdf link PDF open access
    • Sodium-Glucose Transport Protein 2 Inhibitor Use for Type 2 Diabetes and the Incidence of Acute Kidney Injury in Taiwan
      JAMA Network Open
      Research
      February 22, 2023

      This cohort study investigates the association of sodium-glucose transport protein 2 inhibitor (SGLT2i) use and the incidence of acute kidney injury (AKI) in patients with type 2 diabetes in Taiwan.

      Diabetes and Endocrinology Diabetes Adverse Drug Events Clinical Pharmacy and Pharmacology Acute Kidney Injury
      Full Text | pdf link PDF open access
    • Effect of Adjunctive Simvastatin on Depressive Symptoms Among Adults With Treatment-Resistant Depression: A Randomized Clinical Trial
      JAMA Network Open
      Research
      February 20, 2023

      This randomized clinical trial of adults with treatment-resistant depression assesses whether adjunctive simvastatin therapy improves depressive symptoms compared with placebo.

      Cardiology Dyslipidemia Cardiovascular Risk Factors Clinical Pharmacy and Pharmacology Psychiatry and Behavioral Health
      Full Text | pdf link PDF open access
    • Antipsychotic Medication Use Among Older Adults Following Infection-Related Hospitalization
      JAMA Network Open
      Research
      February 17, 2023

      This cohort study assesses antipsychotic medication use among older US adults, including rates of and patient characteristics associated with discontinuation, following infection-related hospitalization.

      Geriatrics Infectious Diseases Clinical Pharmacy and Pharmacology Pharmacoepidemiology Dementia and Cognitive Impairment
      Full Text | pdf link PDF open access
    • Benzodiazepine Receptor Agonists Prescribing for Insomnia Among Adults in Primary Health Care Facilities in Beijing, China
      JAMA Network Open
      Research
      February 17, 2023

      This cross-sectional study examines the benzodiazepine receptor agonists (BZRA) prescribing rate for insomnia among adult patients in primary health care facilities (PHFs) in China.

      Neurology Health Care Safety Pharmacoepidemiology Sleep Medicine Psychiatry and Behavioral Health
      Full Text | pdf link PDF open access
    • Regulatory Approval, Reimbursement, and Clinical Use of Cyclin-Dependent Kinase 4/6 Inhibitors in Metastatic Breast Cancer in the Netherlands
      JAMA Network Open
      Research
      February 16, 2023

      This cohort study examines the postapproval processes and timing for making palbociclib, ribociclib, and abemaciclib available to patients with metastatic breast cancer in a high-income country.

      Health Policy Breast Cancer Cancer Biomarkers Clinical Pharmacy and Pharmacology Genetics and Genomics
      Full Text | pdf link PDF open access
    • Identification of Bradycardia Following Remdesivir Administration Through the US Food and Drug Administration American College of Medical Toxicology COVID-19 Toxic Pharmacovigilance Project
      JAMA Network Open
      Research
      February 14, 2023

      This cohort study examines the incidence of bradycardia occurring during or after administration of remdesivir in patients with COVID-19 through the US Food and Drug Administration American College of Medical Toxicology COVID-19 Toxic (FACT) Pharmacovigilance Project.

      Public Health Rhythm Disorders Cardiology Toxicology Adverse Drug Events
      Full Text | pdf link PDF open access
    • Effect of Rivaroxaban vs Enoxaparin on Major Cardiac Adverse Events and Bleeding Risk in the Acute Phase of Acute Coronary Syndrome: The H-REPLACE Randomized Equivalence and Noninferiority Trial
      JAMA Network Open
      Research
      February 10, 2023

      This randomized equivalence and noninferiority trial compares safety and efficacy of enoxaparin vs rivaroxaban 2.5 or 5 mg for patients with acute coronary syndrome (ACS) in the acute phase.

      Cardiology Clinical Pharmacy and Pharmacology Adverse Drug Events Anticoagulation Acute Coronary Syndromes
      Full Text | pdf link PDF open access
    • Trends in Out-of-Pocket Costs for and Characteristics of Pharmacy-Dispensed Buprenorphine Medications for Opioid Use Disorder Treatment by Type of Payer, 2015 to 2020
      JAMA Network Open
      Research
      February 10, 2023

      This cross-sectional study evaluates trends in out-of-pocket costs for and characteristics of pharmacy-dispensed buprenorphine medications for opioid use disorder treatment by type of payer from 2015 to 2020.

      Clinical Pharmacy and Pharmacology Health Care Economics, Insurance, Payment Pharmacoeconomics Health Policy Substance Use and Addiction Medicine
      Full Text | pdf link PDF open access
    • Rivaroxaban for Patients With Acute Coronary Syndromes—Where Do We Stand?
      JAMA Network Open
      Opinion
      February 10, 2023
      Cardiology Clinical Pharmacy and Pharmacology Adverse Drug Events Bleeding and Transfusion Anticoagulation
      Full Text | pdf link PDF open access
    • Association Between Opioid Tapering and Subsequent Health Care Use, Medication Adherence, and Chronic Condition Control
      JAMA Network Open
      Research
      February 7, 2023

      This cohort study examines outcomes associated with tapering of opioid therapy in patients who have received stable doses for 1 year, including subcohorts of those with hypertension or diabetes.

      Clinical Pharmacy and Pharmacology Treatment Adherence Diabetes Diabetes and Endocrinology Hypertension
      Full Text | pdf link PDF open access
    • Association of the Chantix Recall With US Prescribing of Varenicline and Other Medications for Nicotine Dependence
      JAMA Network Open
      Research
      February 6, 2023

      This cross-sectional study evaluates the association between the 2021 varenicline tartrate recall and prescribing of varenicline and other medications for nicotine dependence in a large US national patient cohort.

      Health Policy Health Care Safety Tobacco and e-Cigarettes Regulatory Agencies Pharmacoepidemiology
      Full Text | pdf link PDF open access
    • Association of Anthracycline With Heart Failure in Patients Treated for Breast Cancer or Lymphoma, 1985-2010
      JAMA Network Open
      Research
      February 3, 2023

      This case-control study compares the long-term incidence of congestive heart failure in patients treated for breast cancer or lymphoma with anthracycline therapy compared with healthy controls from the same community.

      Cardiology Clinical Pharmacy and Pharmacology Breast Cancer Cancer Survivorship Adverse Drug Events
      Full Text | pdf link PDF open access
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