Explore JAMA Network Open’s collection on statistics and research methods, including open access articles addressing the design, conduct, and analysis of clinical research.
This cross-sectional study examines the status of randomized clinical trials (RCTs) whose primary outcome changed between trial registration and publication and quantifies the association of this change with the reported intervention effect size.
This comparative effectiveness study examines current US Centers for Medicare & Medicaid Services 30-day mortality risk models vs novel risk models for acute myocardial infarction, heart failure, and pneumonia hospitalizations.
This cross-sectional study uses machine reading to estimate the magnitude of female underrepresentation in clinical studies worldwide.
This post hoc precision medicine analysis of the Flexible Lifestyles Empowering Change (FLEX) trial estimates an individualized treatment rule to uncover subgroups of responders for key outcomes in diabetes self-management among youth.
This cross-sectional study characterizes postapproval clinical trials sponsored by pharmaceutical companies of therapeutics approved by the US Food and Drug Administration (FDA) without postmarketing requirements or commitments.
This study assesses whether an association exists between the sponsorship and conduct of a phase 3 randomized clinical trial investigating a cancer drug and the lack of supporting phase 2 trial evidence for that drug.
This systematic review examines the level and prevalence of spin in presenting findings that are not statistically significant in published reports of cardiovascular randomized clinical trials (RCTs).
This systematic review and meta-analysis examines randomized clinical trials (RCTs) of immune checkpoint inhibitors to evaluate the use of milestone rate and milestone restricted mean survival time as intermediate end points in immune checkpoint inhibitor trials.
This qualitative study of medical research language assesses changes in 5 medical journals and broader changes in the culture of clinical investigation during the last 40 years.
This randomized survey experiment of a nationally representative sample of US adults estimates payment-associated deception about eligibility for an online survey and assesses whether there is an association between payment amount and deception frequency.
This review study examines noncommercial US funders’ policies on clinical trial transparency, including clinical trial registration, summary results sharing, and individual patient data sharing activities.
This case-control study uses nationwide health plan data from Israel to compare the extent of chronic comorbidities and mortality hazard between Holocaust survivors and an age-matched control group of individuals born in Israel.
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