Explore JAMA’s influential critical care medicine series, including new sepsis definitions and guidelines, trials of ventilation strategies, and more.
This randomized clinical trial compares the effect of a communication-priming intervention vs usual care on patient-physician discussions on goals of care for hospitalized older patients with serious illness.
This cohort study evaluates intensive care unit admissions as well as characteristics and outcomes of children receiving intensive care in the US.
This randomized clinical trial examines whether systematic 4-factor prothrombin complex concentrate administration combined with a ratio-based transfusion protocol is superior to ratio-based transfusion alone in reducing 24-hour total blood product consumption in patients at risk of massive transfusion.
This randomized clinical trial examines the effect of initiation of a renin-angiotensin system inhibitor (ACE inhibitor or an angiotensin receptor blocker) on the composite outcome of hospital survival and organ support through 21 days in hospitalized patients with COVID-19.
This exploratory study of a multiplatform randomized trial investigating the effects of therapeutic-dose heparin in early-pandemic hospitalized COVID-19 patients describes findings from 3 statistical approaches to detecting differences of treatment effect in clinically relevant patient subgroups.
This randomized clinical trial assesses if balanced solutions decrease the rise of plasma chloride compared with saline, 0.9%, in critically ill children.
This randomized clinical trial compares the effect of early high-flow oxygen therapy vs standard oxygen therapy on length of hospital stay in children with acute hypoxemic respiratory failure.
This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.
This cohort study examines data for hospital length of stay to determine its association with early use of steroids among pediatric patients hospitalized for COVID-19 who did not have multisystem inflammatory syndrome in children.
This randomized clinical trial assesses the effect of selective decontamination of the digestive tract compared with standard care on in-hospital mortality among critically ill patients receiving mechanical ventilation.
This cohort study investigates the association between extracorporeal membrane oxygenation survivorship and postdischarge mental health diagnoses among adult survivors of critical illness.
This quality improvement study evaluates whether a low-technology cardiac arrest prevention practice bundle decreases in-hospital cardiac arrest rate.
This systematic review and meta-analysis investigates the use of presepsin for the diagnosis of neonatal early-onset sepsis.
This randomized clinical trial assesses whether high-flow nasal cannula therapy is noninferior to continuous positive airway pressure for time to liberation from respiratory support among acutely ill children clinically assessed to require noninvasive respiratory support in pediatric critical care units.
This clinical trial compares the efficacy of nitric oxide applied into the cardiopulmonary bypass oxygenator vs standard care on ventilator-free days in children younger than 2 years undergoing surgery for congenital heart disease.
This pragmatic randomized clinical trial compares the efficacy and adverse events of prone positioning in adults not intubated with acute hypoxemia and COVID-19 vs patients receiving usual care without prone positioning.
This randomized clinical trial compares the total duration of invasive mechanical ventilation, need for reintubation, and ventilator-free days associated with noninvasive high-frequency oscillatory ventilation, nasal continuous positive airway pressure, and nasal intermittent positive pressure ventilation used in preterm neonates.
This clinical trial evaluates the noninferiority of high-flow nasal cannula (HFNC) therapy vs continuous positive airway pressure (CPAP) as the first-line mode of noninvasive respiratory support following extubation on time to liberation from respiratory support.
This randomized clinical trial assesses the effect of treatment with an antiplatelet agent vs no antiplatelet therapy on days alive and free of intensive care unit respiratory or cardiovascular organ support within 21 days among patients critically ill with COVID-19.
This prospective cohort study compares the risk of posttraumatic stress disorder among family members of patients with COVID-19-related acute respiratory distress syndrome (ARDS) vs ARDS from other causes.
Customize your JAMA Network experience by selecting one or more topics from the list below.