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    Clinical Implications of Basic Neuroscience

    Explore this JAMA Neurology review series devoted to explaining the potential clinical applications of preclinical research and development.

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    • Reward-Processing Behavior in Depressed Participants Relative to Healthy Volunteers: A Systematic Review and Meta-analysis
      JAMA Psychiatry
      Research
      December 1, 2020

      This systematic review and meta-analysis evaluates whether depression is associated with impairments in reward-processing behavior.

      Depressive Disorders Psychiatry and Behavioral Health Neuroscience and Psychiatry
      Full Text | pdf link PDF open access
    • Huntingtin-Lowering Therapies for Huntington Disease: A Review of the Evidence of Potential Benefits and Risks
      JAMA Neurology
      Review
      June 1, 2020

      This review examines data from human and animal studies of the altered huntingtin protein associated with Huntington disease to assess the risk-benefit profile of huntingtin-lowering therapies for the treatment of people with Huntington disease.

      Genetics and Genomics Neurogenetics Neurology Huntington Disease Dementia and Cognitive Impairment
      Full Text | pdf link PDF
    • Extracellular Mitochondria for Therapy and Diagnosis in Acute Central Nervous System Injury
      JAMA Neurology
      Review
      January 1, 2018

      This review summarizes findings from studies that suggest that after central nervous system injury, mitochondria can be released into extracellular space as a “help-me signal” to augment recovery.

      Trauma and Injury Traumatic Brain Injury Cerebrovascular Disease Neurology Stroke
      Full Text | pdf link PDF
    • Electronic Dura Mater Meddling in the Central Nervous System
      JAMA Neurology
      Review
      April 1, 2017

      This review of preclinical applications assesses the potential of the electronic dura mater to deliver electrical and chemical stimulation to targeted areas of the central nervous system for extended periods.

      Neurology
      Full Text | pdf link PDF
    • Association of Mutations in TBK1 With Sporadic and Familial Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
      JAMA Neurology
      Review
      January 1, 2017

      This review discusses the pathogenicity of variants that affect protein levels of TBK1, the gene associated with amyotrophic lateral sclerosis and frontotemporal dementia.

      Genetics and Genomics Neurology Neuromuscular Diseases Amyotrophic Lateral Sclerosis Dementia and Cognitive Impairment
      Full Text | pdf link PDF
    • Potential of the Antibody Against cis –Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury
      JAMA Neurology
      Review
      November 1, 2016

      This review assesses the therapeutic potential of the monoclonal antibody to the unique prolyl isomerase Pin1 in the diagnosis and prevention of Alzheimer disease, traumatic brain injury, and chronic traumatic encephalitis.

      Traumatic Brain Injury Neurology Dementia and Cognitive Impairment Pathology and Laboratory Medicine Trauma and Injury
      Full Text | pdf link PDF free
    • Synthetic Nucleic Acids and Treatment of Neurological Diseases
      JAMA Neurology
      Review
      October 1, 2016

      This study reviews the use of ASOs for the treatment of neurological disorders.

      Neurology Neuromuscular Diseases Drug Development Clinical Pharmacy and Pharmacology Genetics and Genomics
      Full Text | pdf link PDF free
    • Molecular Pathogenic Basis for GABRG2 Mutations Associated With a Spectrum of Epilepsy Syndromes, From Generalized Absence Epilepsy to Dravet Syndrome
      JAMA Neurology
      Review
      August 1, 2016

      This review article discusses the molecular pathogenic basis for idiopathic generalized epilepsies associated with mutations in the inhibitory GABAA receptor γ2 subunit gene, GABRG2, an established epilepsy gene.

      Genetics and Genomics Epilepsy and Seizures Neurogenetics Neurology Pediatrics
      Full Text | pdf link PDF free
    • Chemogenetics—A Transformational and Translational Platform
      JAMA Neurology
      Review
      November 1, 2015

      This article discusses how a new therapeutic system has the potential to augment neuronal and glial signaling and activity for basic and translational applications.

      Neurology Research, Methods, Statistics Parkinson Disease Movement Disorders Genetics and Genomics
      Full Text | pdf link PDF free
    • Blood-Borne Revitalization of the Aged Brain
      JAMA Neurology
      Review
      October 1, 2015

      This article discusses putative mechanisms for blood-borne brain rejuvenation and suggests promising avenues for future research and development of therapies.

      Neurology Geriatrics Hematology Psychiatry and Behavioral Health Dementia and Cognitive Impairment
      Full Text | pdf link PDF free
    • Neuroelectronics and Biooptics: Closed-Loop Technologies in Neurological Disorders
      JAMA Neurology
      Review
      July 1, 2015

      This article discusses how advances in experimental closed-loop systems hold promise for improved clinical benefit in patients with neurological disorders.

      Neurology Clinical Decision Support Epilepsy and Seizures Movement Disorders
      Full Text | pdf link PDF free
    • Treatment of Elderly Patients With Glioblastoma: A Systematic Evidence-Based Analysis
      JAMA Neurology
      Review
      May 1, 2015

      This systematic review examined survival data in elderly patients with glioblastoma being treated with temozolomide therapy alone vs radiotherapy alone.

      Neuro-oncology Neurology Oncology Geriatrics Radiation Oncology
      Full Text | pdf link PDF free
    • Modulation of GluN3A Expression in Huntington Disease: A New N -Methyl- d -Aspartate Receptor–Based Therapeutic Approach?
      JAMA Neurology
      Review
      April 1, 2015

      This study concludes that information on the causative events of Huntington disease might help identify biomarkers that could be used to facilitate clinical trials.

      Movement Disorders Neurogenetics Neurology Huntington Disease Dementia and Cognitive Impairment
      Full Text | pdf link PDF free
    • Inflammation and Neuroprotection in Traumatic Brain Injury
      JAMA Neurology
      Review
      March 1, 2015

      This review article found that the central nervous system inflammatory reaction to brain injury can be deleterious or beneficial, with individual cell populations possessing the ability to be neurotoxic or neuroprotective.

      Traumatic Brain Injury Neurology Trauma and Injury Otolaryngology Hematology
      Full Text | pdf link PDF free has multimedia
    • Role of Endogenous Neural Stem Cells in Spinal Cord Injury and Repair
      JAMA Neurology
      Review
      February 1, 2015

      This brief review describes the beneficial functions of endogenous neural stem cells after spinal cord injury.

      Neurology Spinal Cord Disorders
      Full Text | pdf link PDF free
    • Targeted Drug Delivery to Flow-Obstructed Blood Vessels Using Mechanically Activated Nanotherapeutics
      JAMA Neurology
      Review
      January 1, 2015

      This review explores a novel nanotherapeutic drug-delivery platform that is mechanically activated within blood vessels by high-fluid shear stresses to selectively target drugs to sites of vascular obstruction.

      Clinical Pharmacy and Pharmacology Surgery Vascular Surgery Neurology Stroke
      Full Text | pdf link PDF free
    • IDH Mutation in Glioma: New Insights and Promises for the Future
      JAMA Neurology
      Review
      October 1, 2014

      Turkalp et al review the role of isocitrate dehydrogenase (IDH) in normal physiology and describe aberrations in the IDH pathway that are associated with gliomagenesis, and they review recent work examining the effect of IDH-targeted therapy in cancers harboring IDH mutation and determine how this work has expanded our understanding of the role of IDH in the development and progression of glioma.

      Genetics and Genomics Oncology Cancer Genetics Neuro-oncology Neurology
      Full Text | pdf link PDF free
    • Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chloride Cotransporter KCC2–Mediated Chloride Extrusion in Peripheral Neuropathic Pain
      JAMA Neurology
      Review
      May 1, 2014

      A novel analgesic strategy for neuropathic pain is to restore spinal ionotropic inhibition by enhancing KCC2-mediated chloride extrusion. Kahle et al review the data on which this theory is based, discuss high-throughput screens that have searched for small-molecule activators of KCC2, and propose other strategies of KCC2 activation.

      Pain Medicine Neurology Neuromuscular Diseases Neuropathy
      Full Text | pdf link PDF free
    • Amyloid-β and Tau: The Trigger and Bullet in Alzheimer Disease Pathogenesis
      JAMA Neurology
      Review
      April 1, 2014

      Bloom discusses the defining features of Alzheimer disease and the roles amyloid-β and tau play in the disease’s development.

      Dementia and Cognitive Impairment Genetics and Genomics Neurogenetics Neurology
      Full Text | pdf link PDF free
    • Newborn Screening for Fragile X Syndrome
      JAMA Neurology
      Review
      March 1, 2014

      Tassone discusses the inclusion of fragile X syndrome in newborn screening.

      Neurogenetics Neurology Congenital Defects Neonatology Pathology and Laboratory Medicine
      Full Text | pdf link PDF free
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