Genomics and Precision Health

This Viewpoint examines the 2018 Nuffield Council on Bioethics report on the social and ethical issues of heritable genome editing, and discusses the report’s rejection of the notion of genomic essentialism.

This Genomics and Precision Health article reviews clinical applications of tumor DNA sequencing to direct treatment of melanoma and of myeloid, lung, and colorectal cancers.

This JAMA Insights article explains how precision health, which uses mechanistic insights to treat individual patients based on their unique abnormalities, can treat variants causing cystic fibrosis.

This JAMA Insights article explains cell-free circulating tumor DNA and its utility in noninvasive cancer detection and characterization, prediction of treatment response, monitoring of disease relapse, and identification of mechanisms of resistance to targeted therapies.

This JAMA Insights article explains how preimplantation genetic diagnosis can help reduce the risk of inherited genetic conditions among newborns.

This JAMA Insights article explains process of cascade screening for familial hypercholesterolemia and its efficacy in reducing risk of atherosclerotic cardiovascular disease.

This Genomics and Precision Health article discusses the advantages of chromosomal microarray analysis over G-banded karotyping for evaluating neurodevelopmental disorders in children.

This Genomics and Precision Health essay discusses the risks and potential benefits of performing genome sequencing in healthy people.