Explore this JAMA Psychiatry essay and review series that explains the molecular and neural basis of mental health disorders.
This meta-analysis compares the efficacy and acceptability of different noninvasive brain stimulation interventions for treating negative symptoms.
This case-control study examines whether mismatch negativity event-related potential amplitude, which is deficient in schizophrenia, is reduced in young people at clinical high risk for psychosis and associated with outcomes, accounting for effects of antipsychotic medication use.
This systematic review and meta-analysis examines changes in cortical thickness in individuals during differing phases across the course of schizophrenia.
This randomized clinical trial examines the use of simultaneous cognitive behavioral therapy and transcranial direct current stimulation in the treatment of major depressive disorder in adults.
This cohort study uses machine learning techniques to cluster, compare, and combine subgroup solutions using clinical and brain structural imaging data from early psychosis and depression stages.
This cohort study investigates the course of cognition from elementary school to old age among individuals with schizophrenia and other psychotic disorders to test neurodevelopmental and neurodegenerative theories of psychotic disorders.
This community-based cohort study evaluates how copy number variant (CNV) risk scores, common genetic variation indexed by polygenic scores, and environmental factors combine to associate with cognition and psychopathology in the Philadelphia Neurodevelopmental Cohort (PNC).
This mendelian randomization study investigates the relationship between inflammation and changes in brain structures in vivo and explores a transcriptome-driven functional basis with relevance to mental illness.
This meta-analysis evaluates differences in reinforcement-learning behaviors between patients with depression and anxiety and control individuals.
This population-based administrative register study investigates whether mental disorders antedate dementia among 1.7 million New Zealand citizens across 3 decades of observation.
This study evaluates the association of Alzheimer disease and related dementias with common neuropsychiatric symptoms.
This case-control study assesses whether aberrant belief updating can be observed in a relatively simple motion direction estimation task in patients with schizophrenia or schizoaffective disorder compared with healthy control participants.
This article explains methods for computational psychiatry to study hallucinations in humans and murine models.
This cross-sectional study assesses brain response during unexpected receipt or omission of a salient sweet stimulus in women with eating disorders and healthy controls to test for evidence of whether this brain response is associated with the ventral striatal-hypothalamic circuitry.
This mixed cross-sectional–cohort study evaluates associations among computational model–derived reinforcement learning parameters, depression symptoms, and symptom changes after cognitive behavioral therapy.
This Viewpoint discusses applying family history of severe mental illness to create a model for early detection of risk factors and intervention beginning in childhood.
This cohort study examines the degree to which magnetic resonance imaging–assessed cerebral cortical thickness development is associated with cannabis use in a longitudinal sample of adolescents.
This Viewpoint discusses the potential use of non-μ treatments of opioid use disorder and provides an overview of considerations for the field as it moves to develop such agents.
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