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    Users' Guide to the Medical Literature

    Explore the foundations of evidence-based medicine with JAMA’s Users’ Guide to the Medical Literature collection. Learn to understand and interpret clinical research!

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    • How to Use and Interpret the Results of a Platform Trial: Users’ Guide to the Medical Literature
      JAMA
      Review
      January 4, 2022

      This Users’ Guide to the Medical Literature describes the fundamental concepts of platform trials and master protocols and reviews issues in the conduct and interpretation of these studies.

      Research, Methods, Statistics
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
    • How to Interpret and Use a Clinical Practice Guideline or Recommendation: Users’ Guides to the Medical Literature
      JAMA
      Review
      October 19, 2021

      This Users’ Guide to the Medical Literature provides suggestions for understanding guideline methods and recommendations for clinicians seeking direction in evaluating clinical practice guidelines for potential use in their practice.

      Guidelines Conflict of Interest
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
    • Evaluating Machine Learning Articles
      JAMA
      Opinion
      November 12, 2019
      Health Informatics
      Full Text | pdf link PDF
    • How to Read Articles That Use Machine Learning: Users’ Guides to the Medical Literature
      JAMA
      Review
      November 12, 2019

      This Users’ Guide to the Medical Literature discusses the use of machine learning models as a diagnostic tool, and it explains the important steps needed for making these models and the outcomes they derive clinically effective.

      Health Informatics
      Full Text | pdf link PDF has multimedia
    • Discrimination and Calibration of Clinical Prediction Models: Users’ Guides to the Medical Literature
      JAMA
      Review
      October 10, 2017

      This Users’ Guide to the Medical Literature discusses discrimination and calibration, 2 primary ways to measure and compare the accuracy of clinical risk prediction models.

      Research, Methods, Statistics
      Full Text | pdf link PDF has multimedia
    • Adjusted Analyses in Studies Addressing Therapy and Harm: Users’ Guides to the Medical Literature
      JAMA
      Review
      February 21, 2017

      This Users’ Guide to the Medical Literature discusses strategies for adjusting analyses as a way of addressing prognostic imbalance in studies of therapy and harm.

      Research, Methods, Statistics
      Full Text | pdf link PDF has multimedia
    • How to Read a Systematic Review and Meta-analysis and Apply the Results to Patient Care: Users’ Guides to the Medical Literature
      JAMA
      Review
      July 9, 2014
      Surgery Ischemic Heart Disease Perioperative Care and Consultation Acute Coronary Syndromes Cardiology
      Full Text | pdf link PDF has multimedia
    • How to Use a Subgroup Analysis: Users’ Guide to the Medical Literature
      JAMA
      Review
      January 22, 2014

      Sun and coauthors provide 5 criteria to help clinicians distinguish credible subgroup analyses from spurious subgroup analyses.

      Orthopedics Cardiovascular Risk Factors Cardiology Trauma and Injury Guidelines
      Full Text | pdf link PDF has multimedia
    • How to Use a Noninferiority Trial: Users' Guides to the Medical Literature
      JAMA
      Review
      December 26, 2012
      Noninferiority trials compare a novel treatment with the existing standard in order to determine if the new approach might lessen potential harms or burdens for the patient. In this Users’ Guide, Mulla and coauthors present a practical approach to interpreting these increasingly common studies.
      Research, Methods, Statistics Venous Thromboembolism
      Full Text | pdf link PDF
    • How to Use an Article Reporting a Multiple Treatment Comparison Meta-analysis
      JAMA
      Review
      September 26, 2012
      Interpreting the results of a multiple treatment comparison (MTC) meta-analysis can be a challenge. Mills and coauthors provide a 3-step approach in this Users’ Guide to help demystify the MTC for clinicians.
      Research, Methods, Statistics Anxiety Disorders Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF
    • How to Use an Article About Quality Improvement
      JAMA
      Review
      November 24, 2010
      Health Care Quality
      Full Text | pdf link PDF
    • How to Use an Article About Genetic Association: C: What Are the Results and Will They Help Me in Caring for My Patients?
      JAMA
      Review
      January 21, 2009
      Genetics and Genomics
      Full Text | pdf link PDF
    • How to Use an Article About Genetic Association: B: Are the Results of the Study Valid?
      JAMA
      Review
      January 14, 2009
      Genetics and Genomics
      Full Text | pdf link PDF
    • How to Use an Article About Genetic Association: A: Background Concepts
      JAMA
      Review
      January 7, 2009
      Genetics and Genomics
      Full Text | pdf link PDF
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